Changes in Estrus Cycle and Fertility in Female Rats with ACTH- and Corticosteroid-Induced Experimental Hyperglycemia and Diabetes

Year 1981, Volume: 34 Issue: 4, 595 - 606, 31.12.1981

Fuat Taner

Abstract

Bu deneysel çalışmada ACTH ve kortikosteroid hormon zerkleriyle sürrenal uyarım yoluyla hiperglisemi ve diyabet oluşturulan dişi sıçanlarda östrus siklusu ve fertilitedeki değişiklikler incelenmiştir. Her iki hormon grubu sürekli hiperglisemi oluşturmuş, ancak üreme sonuçları farklı bulunmuştur. ACTH uygulanan grupta östrus periyodu aktif olmasına rağmen fertilite tamamen durmuştur. Kortikosteroid uygulanan grupta ise östrus sayısı artmış, anöstrus sayısı azalmış, ancak fertilite oranı %50’ye düşmüştür. Prednisolon asetat’ın sınırlı bir östrojenik etkiye sahip olabileceği; ACTH’ın ise sürrenal korteks üzerinde katabolizan uyarımıyla ovulasyon ve implantasyonun önüne geçerek fertiliteyi engellediği sonucuna varılmıştır.

Keywords

ACTH , kortikosteroid hormon , hiperglisemi , deneysel diyabet , östrus siklusu , fertilite , glukokortikoidler , metilprednizolon

ACTH ve Kortikosteroid Hormon Zerkleriyle Deneysel Hiperglisemi ve Diabet Yapılmış Dişi Sıçanlarda Östrus Siklusu ve Fertilitede Değişmeler

Abstract

This study examines changes in estrus cycle and fertility in female rats with experimental hyperglycemia and diabetes induced via adrenal stimulation—by injecting ACTH or corticosteroid hormones (Depo-Medrol). Results show that both hormone groups develop sustained hyperglycemia, but differ in reproductive outcomes. ACTH-treated rats experienced a complete loss of fertility, despite estrus cycle activity, whereas corticosteroid-treated rats showed increased estrus periods and decreased anestrus counts, but a fertility rate of only 50%. The findings suggest prednisolone acetate may possess mild estrogenic effects, while ACTH likely suppresses ovulation and implantation through its strong catabolic activation of adrenal cortex functions.

Keywords

ACTH , corticosteroid hormone , hyperglycemia , experimental diabetes , estrus cycle , fertility , glucocorticoids , methylprednisolone

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