Dinitrochlorobenzene (NDCB) Testing in Various Diseases

Erdem Alptuna

TR EN

Dinitrochlorobenzene (NDCB) Testing in Various Diseases

Abstract

A total of 36 patients were administered the 2.4-dinitrochlorobenzene (DNCB) test to determine delayed-type hypersensitivity (TTH) and, consequently, T-cell function in patients with chronic kidney disease, chronic liver disease, metastatic cancer, acute leukosis, and malignant lymphoma. Analysis of the test results revealed a close relationship between TTH reactions and NPN in patients with chronic kidney disease. It was determined that high levels of NPN inhibited T-cell function, and that this was reversible with normalization of NPN. The results obtained with DNCB in acute leukosis and malignant lymphoma are consistent with international literature. It was observed that TTH in patients with chronic liver disease was slightly decreased compared to normal levels.

Keywords

Kidney, T Cells, function

Supporting Institution

Ankara Üniversitesi Tıp Fakültesi Gastroenteroloji Kliniği Kürsüsü

References

1 — Rogoch, A., Gastroenterology, McGraw-Hill Book Company, Blakiston Pub. New York. s. 739, 1973.
2 — Sherlock, S., Diseases of the Liver and Biliary System, Blackwell Scientific Pub., Oxford and Edinburgh, 4th Edward Printing, s. 430, 1971.
3 — Starauss, M. B., Welt, L. G., Diseases of the Kidney, Little Brown and Comp. Boston, 2nd Ed. s. 739-405, 1971.
4 — Willams, W. J., Beutler, E., Erslev, A. J., Rundles, R. W., Haematology, McGraw-Hill Book Comp. New York, Chap. 157 ve 160, 1972.
5 — Gold, P., Freedman, S., Demonstration of tumor specific antigens in human colonic carcinomata by immunologic tolerance and adsorption techniques, J. Exp. Med. 121:439, 1965.
6 — Hakkinen, I., An immunochemical method for detecting carcinomatous secretion from gastric juice, Scand. J. Gastro. 1:28, 1966.
7 — Uriel, J., de Nechaud, B., Stanislawski, M., Birengwajg, M., Le diagnostic du cancer primaire de foie par des méthodes immunologiques, Presse. Med. 76:1415, 1968.
8 — Waksman, B. H., Measurement of cell mediated-immunity, New Eng. J. Med. 268:431, 1972.
9 — Catalona, W. J., Taylor, P. T., Rabson, A. S., Chretien, P. B.: A method for DNCB contact sensitisation: A clinicopathological study, New Engl. J. Med. 286:399, 1972.
10 — Eisen, H. N., Belman, S., Carsten, M. E.: The reaction of 2,4-dinitrochlorobenzene sulfonic acid with free amino groups of proteins, J. Am. Chem. Soc. 75:4583, 1953.

11 — Eisen, H. N., Tabachnic, M.: Elicitation of allergic contact dermatitis in the guinea pig: The distribution of bound dinitrobenzenes groups within the skin and quantitative determination of the extent of combination of 2,4-dinitrochlorobenzene with epidermal protein in vivo, J. Exp. Med. 108:773, 1958.
12 — Eisen, H. N., Orris, L., Belman, S.: Elicitation of delayed allergic skin reactions with haptens: The dependence of elicitation on hapten combination with protein, J. Exp. Med. 95:473, 1952.
13 — Sadoff, L., Giovsky, M., Alenty, A.: DNCB test in cancer patient, New Engl. J. Med. 287:47, 1972.
14 — Hunt, J. S., Silverstein, M. J., Sparkes, F. C., Haskell, G. C. M.: Granulomatous hepatitis: A complication of BCG immunotherapy, New Engl. J. Med. 286:399, 1972.
15 — Sadoff, L.: The usefulness of medroxyprogesterone acetate in treatment of advanced cancer, baskıda, mektup ile, 1973.
16 — Brown, R. S., Haynes, H. A., Folley, H. T., Gedwin, H. A., Berard, C. W., Carbone, P. P.: Hodgkin's: Immunologic, clinical and histologic features of 50 untreated patients, Ann. Int. Med. 67:291, 1967.
17 — Aisenberg, A. C.: Lymphocytopenia in Hodgkin's disease, Blood 25:1037, 1965.
18 — Zamcheck, M., Moore, T. L., Dhar, P., Kupchik, H.: Current concepts: Immunologic evaluation of human digestive tract cancer. Carcinoembryonic antigens, New Engl. J. Med. 286:83, 1972.
19 — Whitehouse, J. M. A., Holborow, E. J.: Smooth muscle antibody in malignant disease, Brit. Med. J. 4:511, 1971.
20 — Sokal, J. E., Primikirios, E.: The delayed skin test response in Hodgkin's disease and lymphosarcoma, Cancer 14:597, 1961.
21 — Barr, M., Fairley, G. H.: Circulating antibodies in reticulosis, Lancet I:1901, 1963.
22 — Leskowitz, S., Philippino, L., Hendrik, C., Graham, J. B.: Immune response with patients with cancer, Cancer 10:1103, 1957.
23 — Aisenberg, A. C.: Studies on Delayed Hypersensitivity in Hodgkin's Disease, J. Clin. Invest. 41:1964, 1962.
24 — Dubin, I. N.: The poverty of the immunological mechanisms in patients with Hodgkin's Disease, Ann. Int. Med. 27:898, 1947.
25 — Longmire, R. L., MacMillan, R., Yelenovsky, R., Armstrong, S.: In vitro splenic Ig synthesis in Hodgkin's Disease, New Engl. J. Med. 289:763, 1973.
26 — Schier, W., Roth, A., Ostroft, G., Schrift, M. H.: Hodgkin's disease and Immunity, Amer. J. Med. 20:94, 1956.
27 — Wisemann, L.: The blood pictures in the primary diseases of the lymphoid system: Their character and significance, JAMA 107:2016, 1936.
28 — Aisenberg, A. C.: Studies on lymphocyte transfer reactions in Hodgkin's disease, J. Clin. Invest. 44:555, 1965.
29 — Smiddy, F. G., Burnell, R. G., Parsons, F. M.: Influence of uremia on the survival of skin homografts, Nature 190:732, 1961.
30 — Lamb, D., Pilney, F., Kelly, W. D., Good, R. A.: A comparative study of the incidence of anergy in patients with carcinoma, leukemia, Hodgkin's disease and other lymphomas, J. Immunol. 89:555, 1962.
31 — Aisenberg, A. C.: Immunologic status of Hodgkin's Disease, Cancer 19:385, 1966.
32 — Peckham, M. J., Cooper, B. M. H.: Proliferation characteristics of the various classes of cells in Hodgkin's disease, Cancer 24:135, 1969.
33 — Walker, G., Doniach, D.: Antibodies and Immunoglobulins in Liver Disease, Gut 9:266, 1968.
34 — Blumberg, B. S., Alter, H. J., Visnich, S.: A new antigen in leukemia sera, JAMA 1191:6541, 1965.
35 — Alptuna, R., Türkyan, M., Koca, Y., Uzunalimoğlu, Ö.: Kontrimmune-elektroforez metodu ile Avustralya (Au/SH) antijeni araştırılmasında yeni bir tampon solüsyonu denenmesi, A. Ü. Tıp Fak. Mec. 25:603, 1972.
36 — Bogoch, A.: Gastroenterology, McGraw-Hill Book Comp. New York, s. 1312, 1973.
37 — Poronetto, F., Schaffner, F., Popper, H.: Immunocytochemical and serologic observations in primary biliary cirrhosis, New Engl. J. Med. 271:1123, 1964.
38 — Doniach, D., Roitt, I. M., Walker, J. G., Sherlock, S.: Tissue antibodies in primary biliary cirrhosis, active chronic hepatitis, cryptogenic cirrhosis and other liver diseases and their clinical implication, Clin. Exp. Immunol. 1:237, 1966.
39 — Lange, K., Wasserman, E., Slobody, L. B.: The significance of serum complement levels with the diagnosis and prognosis of acute and subacute glomerulonephritis.
40 — Wilson, I. D., Williams, R. C., Tobian, L.: Renal tubular acidosis: Three cases with immunoglobulin abnormalities in the patients and their kindred, Amer. J. Med. 43:356, 1967.
41 — Lospalluto, J., Doward, B., Miller, W., Zift, M.: Cryoglobulinemia based on interaction between a macroglobulin and 7S gamma globulin, Amer. J. Med. 32:142, 1962.
42 — Strauss, M. B., Welt, L. G.: Diseases of the Kidney, Little Brown and Comp. Boston. 2nd Ed. s. 1430, 1971.
43 — Mills, J. A.: The immunologic significance of antigen induced lymphocyte transformation in vitro, J. Immunology 97:239, 1966.
44 — Milgram, F., Litvak, B. I., Kand, K.: Humoral antibodies in renal homograft, JAMA 198:226, 1956.
45 — 1971 Year Book of Medicine, Year Book Medical Publications, s. 609, 1971.
46 — Aisenberg, A. C., Leskowitz, S.: Antibody formation in Hodgkin's disease, New Engl. J. Med. 268:1269, 1963.

Details

Primary Language

English

Subjects

Gastroenterology and Hepatology

Journal Section

Research Article

Authors

Erdem Alptuna ^* This is me
Türkiye

Publication Date

December 30, 1974

Submission Date

September 1, 1974

Acceptance Date

December 30, 1974

Published in Issue

Year 1974 Volume: 27 Number: 3-4

IZ

https://izlik.org/JA35NC84CX

APA

Alptuna, E. (1974). Dinitrochlorobenzene (NDCB) Testing in Various Diseases. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 27(3-4), 585-598. https://izlik.org/JA35NC84CX

AMA

1.Alptuna E. Dinitrochlorobenzene (NDCB) Testing in Various Diseases. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1974;27(3-4):585-598. https://izlik.org/JA35NC84CX

Chicago

Alptuna, Erdem. 1974. “Dinitrochlorobenzene (NDCB) Testing in Various Diseases”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 27 (3-4): 585-98. https://izlik.org/JA35NC84CX.

EndNote

Alptuna E (December 1, 1974) Dinitrochlorobenzene (NDCB) Testing in Various Diseases. Ankara Üniversitesi Tıp Fakültesi Mecmuası 27 3-4 585–598.

IEEE

[1]E. Alptuna, “Dinitrochlorobenzene (NDCB) Testing in Various Diseases”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 27, no. 3-4, pp. 585–598, Dec. 1974, [Online]. Available: https://izlik.org/JA35NC84CX

ISNAD

Alptuna, Erdem. “Dinitrochlorobenzene (NDCB) Testing in Various Diseases”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 27/3-4 (December 1, 1974): 585-598. https://izlik.org/JA35NC84CX.

JAMA

1.Alptuna E. Dinitrochlorobenzene (NDCB) Testing in Various Diseases. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1974;27:585–598.

MLA

Alptuna, Erdem. “Dinitrochlorobenzene (NDCB) Testing in Various Diseases”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 27, no. 3-4, Dec. 1974, pp. 585-98, https://izlik.org/JA35NC84CX.

Vancouver

1.Erdem Alptuna. Dinitrochlorobenzene (NDCB) Testing in Various Diseases. Ankara Üniversitesi Tıp Fakültesi Mecmuası [Internet]. 1974 Dec. 1;27(3-4):585-98. Available from: https://izlik.org/JA35NC84CX

Dinitrochlorobenzene (NDCB) Testing in Various Diseases

Çeşitli Hastalıklarda Dinitroklorobenzen (NDCB) Testi

Abstract

Keywords

Supporting Institution

Dinitrochlorobenzene (NDCB) Testing in Various Diseases

Abstract

Keywords

Supporting Institution

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

IZ

Cite