Hipersomatotropinizmin Tedavisinde Hipofiz Işınlamasının Değeri, Tedavi Sonuçlarının Takibinde Faydalı Olan Kriterler Ve Kobalto-Terapi İçin Hasta Seleksiyonu

Year 1974, Volume: 27 Issue: 3-4 , 757 - 784 , 30.12.1974

Selahattin Koloğlu

https://izlik.org/JA27ZY56GM

Abstract

Hipofizer gamma teleradyoterapiye tabi tutulmuş 40 akromegali ve jigantizm vakasında somatotropin (STR) salgısının statik ve dinamik incelemeler ile tedavi sonuçları değerlendirilmiştir. Hipofizer kobalto - terapi şeklinde gerçekleştirilen tedavi ile vakaların 6 57,5 - 65,0'inde münasip sonuçlar elde edilmiştir. Bazal STH seviyelerinin normale avdeti ve otonominin kaybolarak, yerini normal dinamik cevaplara bırakması tam muvaffakiyetin işaretleridir. Tedavinin etkisinin 6 ay sonra başladığı, fakat STH sekresyonunun 2 yıl sonra normalleştiği tespit edilmiştir. Bu tedaviye bağlı hiç bir önemli komplikasyon husule gelmemiştir. Hipersomatotropinizm tedavisinde faydalanılan diğer yöntemlerle elde edilen sonuçlar biraz daha iyi olmakla beraber, bu tedavi yolları ile husule gelen yan etkilerin, fotonterapide müşahede edilmemesi, bu farkı kapamaya yeterli sayılmalıdır. Fotonterapiden, kompresyonsuz ve sella dışı inkişaf göstermiyen hipofizer lezyonların ilk tedavisi olarak taydalanılmaya devam edilmelidir. Kobalto - terapinin etkisi yavaştır; etiolojik lezyonun biyolojik veya anatomik evolusyona devam ettiği vakalar hariç, tedaviyi takiben 2 yıl geçmeden yeni bir tedavi yöntemi tatbikine geçmemeli, hastanın müşahede altında tutulmas ile iktifa edilmelidir.

Keywords

hipofiz ışınlaması , Akromegali , somatotropin

Ethical Statement

-

Supporting Institution

Ankara Üniversitesi Tıp Fakültesi Endokrinoloji ve Metabolizma Hastalıkları Kürsüsü

Project Number

-

Thanks

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The Value of Pituitary Irradiation in the Treatment of Hypersomatotropinism, Criteria Useful for Monitoring Treatment Outcomes, and Patient Selection for Cobalt Therapy

https://izlik.org/JA27ZY56GM

Abstract

The results of treatment were evaluated using static and dynamic studies of somatotropin (STR) secretion in 40 cases of acromegaly and gigantism treated with pituitary gamma teleradiotherapy. Treatment with pituitary cobalt therapy yielded favorable results in 6.57 to 65.0% of cases. Complete success was demonstrated by the return to normal baseline STH levels and the disappearance of autonomy, replaced by normal dynamic responses. The effects of the treatment began after 6 months, but STH secretion normalized after 2 years. No significant complications were observed with this treatment. While the results obtained with other methods used in the treatment of hypersomatotropinism are somewhat better, the fact that the side effects observed with these methods are not observed with photontherapy should be considered sufficient to compensate for this difference. Phototherapy should continue to be used as the initial treatment for pituitary lesions that do not exhibit compression or extrasellar development. Cobalt therapy has a slow onset of action; except in cases where the etiological lesion continues to undergo biological or anatomical evolution, a new treatment modality should not be implemented within two years of treatment, and the patient should be kept under observation.

Keywords

acromegaly , pituitary irradiation , somatotropin

Ethical Statement

-

Supporting Institution

Ankara University Faculty of Medicine, Department of Endocrinology and Metabolic Diseases

Project Number

-

Thanks

-

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