Tromatik İrinli Menenjitin Emetinle Tedavisi
Abstract
This article presents four clinical cases of traumatic purulent meningitis treated with emetine between 1945–1946 at Ankara Numune Hospital. The author, drawing from prior surgical experience, notes emetine’s efficacy against infections from non-specific pus-producing agents, particularly in cases where necrosis hampers sulfonamide efficacy and penicillin is insufficient. Each patient presented with severe neurological deficits due to head trauma, including retained projectiles, depressed fractures, dural lacerations, and cerebral abscesses. Emetine doses ranged from 0.04 to 0.08 g daily and showed rapid improvement in meningeal symptoms. Three cases recovered fully; one died due to an untreated brain abscess spreading to the ventricles. The study emphasizes emetine’s bacteriostatic action, especially its superiority in septic environments over sulfonamides and limited-spectrum antibiotics. It calls for wider clinical use of emetine in neurosurgical and post-traumatic infectious scenarios.
Keywords
emetine, traumatic meningitis, brain abscess, purulent inflammation, cranial trauma, penicillin resistance
References
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