Abstract
1 — Folic acid normalizes the hematological picture in pernicious anemia, but has no effect on neurological changes.
2 — Vitamin B12 normalizes the abnormal hematological and neurological changes in pernicious anemia.
It is estimated that intramuscular injections of vitamin B12 in doses as small as 1 microgram per day will be sufficient. The substance causing allergic reactions in liver extracts is not identical to vitamin B12.
Finally, let's say that the discovery of vitamin B12 does not answer all the questions about pernicious anemia. If neurological and hematological changes are related to the same factor, why don't neurological disorders also occur in patients with pernicious anemia? For example, why are neurological disorders rare in Türkiye? I wonder if there will be any drawbacks to B12 in the future? The future will reveal these. We have learned sufficiently from past experience that in medicine, the best course of action is never to rush and to wait for subsequent publications with dignity.
Keywords
References
- 1 — Castle, W.,B., Ross, J. B. Davidson, C.S., Burchenal, J. H. Foks, H. J. and Ham. T. H.: Extrinsic Factor in Pernicious Anemia; İneffectiveness of purified casein and of indentified components of vitamin B complex. Science, V. 100, No. 2587, July 28, 1944, 81 - 85. ”
- 2 — Clark, G. W.: Vitamin Content of Liver Extracts for Parenteral Use: A comparison of crude and concentrated preperations. Am. J. Med. Science, Apirl 1946, V. 209, No. 4, 520-524.
- 3 — Spies, T.D., Vilter, C.F., Koch, M.B. and Caldwel, M.H.: Observations of the anti-anemic properties of synthetic Folic Acid South Med. J., November 1945, V. 98, No. 11, 707 - 709.
- 4 — Rickes, EL., Brink, N.G. Konjuszy, F.R., Wood, T.R. and Folkers, K. Crystalline Vitamin B12. Science April, 1948, V. 107, No. 2781, 396-397.
- 5 — Smith, E.L.: Purification of anti-pernicious factors formı liver. Nature, April 24, 1948, V. 161 No. 4049, 638-639.
- 6 — Addison, W.: Anemic disease of suprarenal capsule, Lond. Med. Gazette 43: 517-518, 1849.
- 7 — Vierordt, K.: Zahlungen der Blutkörperchen den Menschen Arch. .Physiol, Helik. 11:327-331, 1852.
- 8 — Addison, T.: On the constitutional and local effects of the suprarebal capsules. London, S. Highley, 1855.
- 9 — Castle, W.B. and Locke, E.A.: Abservations on the otiologidal relationship of achilia gastrica to pernicious anemia. J. Clin, Inves. 6:2-3, 1928-29.
- 10 — Murphy. Med. J. Australia Volume 35, No. 17, 1948.
- 11 — Shorb, M. S. JI. Biol. Chem. 1947, 169, 455.
- 12 — Shorb, M.S. Journal of Bacteriology 1947, 53, 669.
- 13 — Lionel Berk, Derek Denny-Brown, Maxwell Finland and William B. Castle Effectiveness of Vitamin B 12 in combined system disease The New England J. of Med. August 26, 1948, © .
- ,14 — Bethell, F.H. and Sturgis, C.C. Relation of therapy in pernicious ane- mia fo changes in nervouş system, early and late results in series of cases obser- ved for periods'of not less than 10 years, and early results for treatment with iolic acid ; Blood 3:69-90, 1948.
- 15 — Ross, J.F., Belding, H. and Paegel, A, L. Develepoment and progres- sion of subacute combined degeneration of spinal cord in patients with perni, cious anemia treated with aybthetic pteroylglutamic acid Blood 3 : 69 - 90, 1948.
- 16 — O. C, Hansen - Pruss Pernicious Anemia: relapse of patients receving Folic acid Am, J. of Scie- nes, Vol 214, Pages 466 - 468, Nev., 1947,
Abstract
1 — Folic acid pernisiyöz anemideki hemâtolojik. tabloyu normale çevirirse de nörolojik değişikliklere hiçbir tesir yoktur.
2 — B 12 vtamini Pernisiyöz anemideki kem anormal hematolojik hem de nörolojik tagayyürleri normale'cevirir.
Adale içine günde 1 mikrogram kdar ufak dozdaki B 12 vitamini zerklerinin kâfi geleceği tahmin: olunmaktadır. Karaciğer ekstrelerinde- ki allerijik reaksiyonlara sebev'olan madde ile vitamin B 12 avni değildir.
Son söz olarak şunu söyliyelim ki B 12 vitaminin keşfi ile pernisiyöz anemi hakkındaki soruların hepsi cevaplandırılmış olmuyor. Nörolojik ve hematolojik değişiklikler ayni faktöre bağıl iseler neden pernisiyöz anemili hastada nörolojik bozukluk da husule gelmiyor. Meselâ ne-
.den Türkiye'de nörolojik bozukluk ender husule geliyor?. Acaba ilerde
bu B 12 nin de bir mahzuru çıkâcak mıdır? Bunları istikbal gösterecektir Tıbda hiçbir zaman acele etmiyerek ağırbaşlılıkla müteakip neşriyatı beklemenin en doğru yol olacağını geçmişteki tecrübelerden kâfi derecede öğrenmiş bulunuyoruz.
Keywords
References
- 1 — Castle, W.,B., Ross, J. B. Davidson, C.S., Burchenal, J. H. Foks, H. J. and Ham. T. H.: Extrinsic Factor in Pernicious Anemia; İneffectiveness of purified casein and of indentified components of vitamin B complex. Science, V. 100, No. 2587, July 28, 1944, 81 - 85. ”
- 2 — Clark, G. W.: Vitamin Content of Liver Extracts for Parenteral Use: A comparison of crude and concentrated preperations. Am. J. Med. Science, Apirl 1946, V. 209, No. 4, 520-524.
- 3 — Spies, T.D., Vilter, C.F., Koch, M.B. and Caldwel, M.H.: Observations of the anti-anemic properties of synthetic Folic Acid South Med. J., November 1945, V. 98, No. 11, 707 - 709.
- 4 — Rickes, EL., Brink, N.G. Konjuszy, F.R., Wood, T.R. and Folkers, K. Crystalline Vitamin B12. Science April, 1948, V. 107, No. 2781, 396-397.
- 5 — Smith, E.L.: Purification of anti-pernicious factors formı liver. Nature, April 24, 1948, V. 161 No. 4049, 638-639.
- 6 — Addison, W.: Anemic disease of suprarenal capsule, Lond. Med. Gazette 43: 517-518, 1849.
- 7 — Vierordt, K.: Zahlungen der Blutkörperchen den Menschen Arch. .Physiol, Helik. 11:327-331, 1852.
- 8 — Addison, T.: On the constitutional and local effects of the suprarebal capsules. London, S. Highley, 1855.
- 9 — Castle, W.B. and Locke, E.A.: Abservations on the otiologidal relationship of achilia gastrica to pernicious anemia. J. Clin, Inves. 6:2-3, 1928-29.
- 10 — Murphy. Med. J. Australia Volume 35, No. 17, 1948.
- 11 — Shorb, M. S. JI. Biol. Chem. 1947, 169, 455.
- 12 — Shorb, M.S. Journal of Bacteriology 1947, 53, 669.
- 13 — Lionel Berk, Derek Denny-Brown, Maxwell Finland and William B. Castle Effectiveness of Vitamin B 12 in combined system disease The New England J. of Med. August 26, 1948, © .
- ,14 — Bethell, F.H. and Sturgis, C.C. Relation of therapy in pernicious ane- mia fo changes in nervouş system, early and late results in series of cases obser- ved for periods'of not less than 10 years, and early results for treatment with iolic acid ; Blood 3:69-90, 1948.
- 15 — Ross, J.F., Belding, H. and Paegel, A, L. Develepoment and progres- sion of subacute combined degeneration of spinal cord in patients with perni, cious anemia treated with aybthetic pteroylglutamic acid Blood 3 : 69 - 90, 1948.
- 16 — O. C, Hansen - Pruss Pernicious Anemia: relapse of patients receving Folic acid Am, J. of Scie- nes, Vol 214, Pages 466 - 468, Nev., 1947,
Details
| Primary Language | English |
|---|---|
| Subjects | Pediatric Hematology and Oncology |
| Journal Section | Systematic Reviews and Meta Analysis |
| Authors | |
| Publication Date | June 30, 1949 |
| Published in Issue | Year 1949 Volume: 3 Issue: 1-2 |