Selim Lenfositli Meningitis (Lenfositik Koriomeningitis)
Abstract
Lymphocytic choriomeningitis (LCM), also known as Armstrong disease, is a rare viral, benign, serous meningitis first described in 1925. Its etiology was clarified in 1934 by Armstrong and Lillie through viral isolation during a Saint Louis epidemic. Traub later confirmed rodents—especially white mice—as reservoirs, with transmission via contaminated food, contact with rodent secretions, or possibly insect bites. Direct human-to-human transmission has not been observed. The disease occurs sporadically or epidemically, typically in fall or spring, among individuals aged 15–40. The clinical picture unfolds in two phases: (1) a prodromal influenza-like stage with fever, malaise, and myalgias, followed by (2) meningeal symptoms including headache, nuchal rigidity, photophobia, and papilledema. CSF findings show elevated lymphocytes, normal glucose and chloride levels, and positive Pandy reaction. Diagnosis is supported by virus isolation and detection of specific antibodies via complement fixation or neutralization tests. Prognosis is typically excellent, with full recovery in 10–15 days and rare sequelae. Treatment is symptomatic, as no specific antiviral therapy exists.
Keywords
lymphocytic choriomeningitis, Armstrong virus, viral meningitis, CSF lymphocytosis
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