Nonguatröz Kretenizmde Kalsitonin

Year 1972, Volume: 25 Issue: 3, 392 - 400, 30.09.1972

Rezan Berki

https://izlik.org/JA83RL92NG

Abstract

Nongutröz kretenlerde kalsitonin salgılanmasını o hipokalsemik etkisi yolu ile incelemek için 3 ay ile 13 yaş arasındaki tedavi edilmemiş 12 nonguatröz kreten ve aynı yaş gurubuna uyan 9 normal kontrole intravenöz akut kalsiyum yüklemesi yapıldı. Yüklemeden önce ve 3, 30, 120 dakika Sonraki kan kalsiyum değerlerinde kretenlerle normaller arasında önemli fark bulunmadı (P> G5). Tiroid glandının konjenital yokluğunda timus ve paratiroid glandları tarafından salgılanan kalsitoninin yeterli olabileceği veya kemik büyümesinin çok yavaş olduğu ve kemik rezorbsiyonunun azaldığı tedavisiz vakalarda normalden az miktardaki kalsitonin ifrazının dahi yeterli olabileceği düşünceleri ileri sürüldü.

Keywords

Kalsitonin , Nonguatröz kretenizm , Hipokalsemi

Calcitonin in Nonguatrous Cretenism

https://izlik.org/JA83RL92NG

Abstract

Acute intraveneus calcium loading was performed in İZ unt- reated nongoitrous crelir aged between 3 months and 13 years, and in 9 normal controls in the same age groub inorder to investigate the secretion of calcitonin by its hipocalcemic effect. Serum calcium levels before and 3, 30, 60, 120 minutes after loading were not significantly different in cretins and normal con- trols (P > %5). Speculations were then made that in the presence of congenital absence of thyroid gland, thymus and parathyroids might secrete adeduate amount of calcitonin, or because of deminished bone growth and resorbtion in hypothroidism smaller amounth of calcitonin might be sufficient.

Keywords

Calcitonin , Nongraves cretinism , Hypocalcemia

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