Farmakoloji Yönünden Sürrenal Medüllası II. Kateşolaminlerin Açığa Çıkmasi (Liberasyon)

Süleyman Oğuz Kayaalp

EN TR

Pharmacological Aspects of the Adrenal Medulla

Abstract

The references have been reviewed concerning the synthesis, uptake, storage and liberation of catecholamines from the adrenal medulla and the influence of drugs on these phenomena. The synthesis of catecholamines in the adrenal medulla resembles that occurring at the sympathetic nerve endings. However, noradrenaline is partly converted to adrenaline in the medulla unlike the sympathetic nerve endings. It is possible that the two catecholamines are stored in the separate chromaffin cells. The origin of the catecholamines in the medulla is in part those taken up from the circulating blood. The uptake of the other phenylethylamine derivatives also occurs in the chromaffin cells of the adrenal medulla. The drugs with quite different pharmacological properties exert the common property of liberating catecholamines from the medulla. The drugs release catecholamines by a direct action or by a reflex action via the central nervous system. Adrenaline and noradrenaline may be released by the drugs in fairly a selective manner. The chromaffin cells have muscarinic receptors in addition to the clasically known nicotinic receptors.

Keywords

Adrenal Medulla, Catecholamines, Adrenaline

Supporting Institution

Ankara University Faculty of Medicine, Department of Pharmacology

Ethical Statement

Ankara University Faculty of Medicine, Department of Pharmacology

Farmakoloji Yönünden Sürrenal Medüllası II. Kateşolaminlerin Açığa Çıkmasi (Liberasyon)

Abstract

Sürrenal medüllasında kateşolaminlerin sentezi, tutulması, depo edilmesi ve liberasyonu ile ilgili olaylar ve bunlar üzerine ilaçların tesirine ilişkin literatür gözden geçirildi. Sürrenal medüllasında kateşolaminlerin sentezi postganglioner sempatik sinir ucunda cereyan edene benzer tarzda olmaktadır. Ancak medüllada, sempatik sinir uçlarının aksine, noradrenalin kısmen adrenalin'e dönüşür. Adrenalin ve noradrenalin'in ayrı hücreler içinde bulunması muhtemeldir. Sürrenal medüllasındaki kateşolaminlerin menşei, kısmen, dolaşan kandan alınıp depo edilen kateşolaminlerdir. Sürrenal medüllası, kateşolaminlerden başka, diğer bazı feniletilamin türevlerini de tutabilir. Tesirleri itibariyle farklı farmakolojik gruplara giren birçok ilaçlar kateşolaminlerin medülla tarafından tutulmasını inhibe etmek özelliğine sahiptirler. İlâçlar direkt tesirle veya santral sinir sistemi aracılığı ile sürrenal medüllasından kateşolamin liberasyonu yapabilirler. Bazı ilâçlar veya tenbih şekilleri daha ziyade noradrenalin, diğer bazıları ise daha ziyade adrenalin liberasyonuna sebep olmaktadırlar. Sürrenal medüllasında sadece nikotinik reseptörler değil fakat ilâveten müskarinik tipte kolinerjik reseptörler de mevcuttur.

Keywords

Sürrenal Medülla, Kateşolaminler, Adrenalin

Supporting Institution

A. Ü. Tıp Fakültesi Farmakoloji Kürsüsü

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Details

Primary Language

Turkish

Subjects

Medical Pharmacology

Journal Section

Review

Authors

Süleyman Oğuz Kayaalp ^* This is me
Türkiye

Publication Date

February 28, 1968

Submission Date

January 1, 1968

Acceptance Date

February 28, 1968

Published in Issue

Year 1968 Volume: 21 Number: 1

IZ

https://izlik.org/JA74HM63ES

APA

Kayaalp, S. O. (1968). Farmakoloji Yönünden Sürrenal Medüllası II. Kateşolaminlerin Açığa Çıkmasi (Liberasyon). Ankara Üniversitesi Tıp Fakültesi Mecmuası, 21(1), 220-240. https://izlik.org/JA74HM63ES

AMA

1.Kayaalp SO. Farmakoloji Yönünden Sürrenal Medüllası II. Kateşolaminlerin Açığa Çıkmasi (Liberasyon). Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1968;21(1):220-240. https://izlik.org/JA74HM63ES

Chicago

Kayaalp, Süleyman Oğuz. 1968. “Farmakoloji Yönünden Sürrenal Medüllası II. Kateşolaminlerin Açığa Çıkmasi (Liberasyon)”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 21 (1): 220-40. https://izlik.org/JA74HM63ES.

EndNote

Kayaalp SO (February 1, 1968) Farmakoloji Yönünden Sürrenal Medüllası II. Kateşolaminlerin Açığa Çıkmasi (Liberasyon). Ankara Üniversitesi Tıp Fakültesi Mecmuası 21 1 220–240.

IEEE

[1]S. O. Kayaalp, “Farmakoloji Yönünden Sürrenal Medüllası II. Kateşolaminlerin Açığa Çıkmasi (Liberasyon)”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 21, no. 1, pp. 220–240, Feb. 1968, [Online]. Available: https://izlik.org/JA74HM63ES

ISNAD

Kayaalp, Süleyman Oğuz. “Farmakoloji Yönünden Sürrenal Medüllası II. Kateşolaminlerin Açığa Çıkmasi (Liberasyon)”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 21/1 (February 1, 1968): 220-240. https://izlik.org/JA74HM63ES.

JAMA

1.Kayaalp SO. Farmakoloji Yönünden Sürrenal Medüllası II. Kateşolaminlerin Açığa Çıkmasi (Liberasyon). Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1968;21:220–240.

MLA

Kayaalp, Süleyman Oğuz. “Farmakoloji Yönünden Sürrenal Medüllası II. Kateşolaminlerin Açığa Çıkmasi (Liberasyon)”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 21, no. 1, Feb. 1968, pp. 220-4, https://izlik.org/JA74HM63ES.

Vancouver

1.Süleyman Oğuz Kayaalp. Farmakoloji Yönünden Sürrenal Medüllası II. Kateşolaminlerin Açığa Çıkmasi (Liberasyon). Ankara Üniversitesi Tıp Fakültesi Mecmuası [Internet]. 1968 Feb. 1;21(1):220-4. Available from: https://izlik.org/JA74HM63ES

Pharmacological Aspects of the Adrenal Medulla

Abstract

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Farmakoloji Yönünden Sürrenal Medüllası II. Kateşolaminlerin Açığa Çıkmasi (Liberasyon)

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