Serum Protein Electrophoresis in Rheumatic Diseases

Abstract

Akut eklem romatizması, spondilit romatoid ve romatoid artrit vakalarında serum proteinleri elektroforetik olarak tetkik edildi. Her üç gurupta da alfa ve gamma fraksiyonlarında artma vardır. Bu artış birinci guruptakilerde diğer guruplardan daha fazladır. Buna mukabil beta globulin fraksiyonu birinci grupta değişmediği halde, 2 ve 3 üncü gruplarda artar. Alfa fraksiyonundaki değişiklik hastalığın aktivasyonunu göstermek bakımından ayrı bir değeri haizdir.

Keywords

• serum proteinleri
• romatoid artrit
• elektroforez

Romatizmal Hastalıklarda Serum Protein Elektroforezi

Abstract

Serum proteins were analyzed electrophoretically in patients with acute rheumatoid arthritis, rheumatoid spondylitis, and rheumatoid arthritis. Increases in alpha and gamma reactivity were observed in all three groups. This increase was greater in the first group than in the other groups. In contrast, the beta globulin fraction remained unchanged in the first group but increased in groups 2 and 3. Changes in the alpha fraction are particularly valuable in indicating disease activation.

Keywords

• Serum proteins
• Rheumatoid arthritis
• Electrophoresis

References

1. 1. DELBARRE, E.: Vue d'ensemble sur les teste biologues en rhumatologie. Rev. du Rhum. 24/5: 347, 1907.
2. 2. DOLE, V. F., WATSON, R.E., ROTHBARD, S.: Electrophoretic changes in the serum protein patterns of patients with scarlet fever and rheumatic fever. J. Clin. Invest. 24: 648, 1945.
3. 3. DOLE, V. F., WATSON, R. F., ROTHBARD, S.: Electrophoretic changes in the serum of a patient with rheumatoid arthritis. J. Clin. Invest. 26: 87, 1947.
4. 4. GRUBB, R.: Interactions between rheumatoid arthritis sera and human gamma globulin. Acta Haemotol. 20: 246, 1958.
5. 5. HARWESTH, H.G.: Proceedings of the IV. Rheumatological Congress, İstanbul. 115, 1959.
6. 6. İMRE, İ., ÇİNTAŞ, M.: Proceedings of the IV. Rheumatol Congress, İstanbul. 102, 1959.
7. 7. JENCKS, W. P., SMITH, R. B., DURRUN, E.L.: The clinical significance of the analysis of serum protein distribution by filter paper electrophoresis. Am. J. Med. 21: 387, 1956.
8. 8. JENCKES, W.P., SMITH, R.B.: Paper electrophoresis as a quantitative method. Biochem. J. 60: 205, 1955.

9. 9. KROOP, İ. G., HEFFER, E. T., SHACKMAN, N.H.: An evaluation of electrophoresis in rheumatic fever. A. H. J. 48: 612, 1954.
10. 10. LAMACHE, A., BOUREL, M.: Les correspondances electrophoretic de la vitesse de sedimentation globulaire. Rev. du Rhum. 24/65: 415, 1957.
11. 11. LEVER, F. W.: Electrophoretic analysis of the plasma proteins in various diseases. Bull. New. Eng. Med. Center 13: 160, 1951.
12. 12. LEVER, F. W., GURD, R. N.: Chemical and immunologic studies on the products of human plasma fractionation. J. Clin. Invest. 30: 99, 1951.
13. 13. LUETSCHER, J. A.: Electrophoretic analysis of plasma and urinary proteins. J. Clin. Invest. 19: 313, 1940.
14. 14. RAVAULT, F. P., VIGNON, G., VIAL, J.: Les anticorps streptococciques dans les maladies rhumatismales. Rev. du Rhum. 25/5: 370, 1957.
15. 15. ROPES, H. W., PERLMANN, G. E., KAUFMAN, D.: The electrophoretic distribution of proteins in plasma in rheumatoid arthritis. J. Clin. Invest. 38: 311, 1954.
16. 16. RUTSTEIN, D., CLARKE, F. H.: Electrophoretic studies in rheumatic fever. Science 101: 669, 1945.
17. 17. SHEDLOVSKY, T., SCUDDER, J.: A comparison of erythrocyte sedimentation rates and electrophoretic patterns of normal and pathological blood. J. Exp. Med. 75: 119, 1952.
18. 18. SÖKMEN, C.: Akut mafsal romatizmasında laboratuar teşhis vasıtaları. Romatizma 1: 9, 1955.
19. 19. SÖKMEN, C.: Kan proteinleri fraksiyonları. Anadolu Kliniği. 2: 54, 1958.
20. 20. SVARTZ, N.: Proceedings of the IV. Rheumatol Congress, İstanbul. 67, 1959.
21. 21. VAUHAN, J. H.: Serum responses in rheumatoid arthritis. Am. J. Med. 26: 596, 1969