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Glucose and Insulin Dynamics of the Mother and Infant in Normal Delivery

Year 1982, Volume: 35 Issue: 1, 41 - 62, 31.03.1982

Abstract

Bu çalışma, normal doğum sırasında ve doğum sonrası erken dönemde anne ve yenidoğanın glukoz ve insülin düzeylerindeki değişimleri incelemektedir. 38 sağlıklı doğum vakasında, doğum süresi ve doğumun aktif fazı göz önünde bulundurularak çeşitli zamanlarda (travay başlangıcı, doğum anı, kordon kanı ve doğumdan 30 dakika sonra yenidoğan kanı) alınan örneklerle metabolik parametreler analiz edilmiştir. Glisemi düzeylerinde travay süresi boyunca anlamlı farklılıklar gözlemlenmiş; özellikle doğumun geç fazlarında hiperglisemi eğilimi belirlenmiştir. Buna karşın insülin düzeylerinde anlamlı bir değişiklik saptanmamıştır. Regresyon analizleri annenin glukoz seviyelerinin yenidoğan glisemi düzeyini etkilediğini göstermiştir. Bu sonuçlar, doğum süresinin ve annenin metabolik durumunun bebeğin erken dönem glukoz dengesini etkileyebileceğini vurgulamaktadır.

References

  • 1 - Bachmann, K.D., Ewerbeck, H., Joppich, G. : Pädiatrie in der Praxis und Klinik : Gustav Fischer Verlag Stuttgart - New York. Cilt III, 1980.
  • 2 - Behrmann, E.R. : Neonatology. Diseases of the fetus and infant. The C.V. Mosby Company Saint Louis, 440, 1973.
  • 3 - Blunck, W. : Endokrines System : In Handbuch der Kinderheilkunde «Physiologie und pathologie der Neugetoronen periode», Springer Verlag-Berlin. Band 1/2, 82, 1971.
  • 4 - Buse, M.G., Roberts, W.J. : The role of placenta in the transfer and metabolism of insulin. J. Clin. Invest. 41 : 29, 1962.
  • 5 - Cornblath, M., Schwartz, R. : Disorders of carbohydrate metabolism in infancy III. Major problems in clinical pediatrics. p : 297, W.B. Saunders Co., 1966.
  • 6 - Cornblath, M., Reisner, S.H. : Blood glucose in the neonate clinical significance. New Engl. J. Med. 273-387, 1965.
  • 7 - Cornblath, M., Ganzon, A.F., Nicolopulos, D. et al. : Studies of carbohydrate metabolism in the newborn infant. Pediatrics, 27, 378, 1961.
  • 8 - Cornblath, M., Wybragt, S.H., Baens, G.S. : Studies of carbohydrate metabolism in the newborn infant. VII. Pediatrics 32, 1007, 1963.
  • 9 - Creery, R.D.G. : Hypoglycemia in the newborn. Lancet 1 : 1423, 1963.
  • 10 - Ditschuneit, F. : Insulin secretion in the newborn babies of normal and diabetic mothers. Acta Diab. Latina 5 supp. 319, 1968.
  • 11 - Dominick, H.Ch., Bachmann, K.D. : Die Hypoglykämie des Neugeborenen. Geburtshilfe und Frauenheilkunde, 39, 564, 1979.
  • 12 - Fanconi G., Wallgren A. : Lehrbuch der Pädiatrie, 9. Auflage, Schwabe Co Verlag. Basel/Stuttgart, 1980.
  • 13 - Felig, P. : Diabetes mellitus - fetal-maternal glucose insulin relationships. In Burrow and Ferris. Medical Complications During Pregnancy. W.B. Saunders Company, Ch 5, 171, 1975.
  • 14 - Feer E., Joppich, G., Schulte, J. : Lehrbuch der Kinderheilkunde, Gustav Fischer Verlag. Stuttgart, New York, 1980.
  • 15 - Girard, J., Stahl, M., Mars, P.W., Herz, G. : Hypoglykämie im Kindesalter. Pädiat. Praxis, 11 : 579, 1972.
  • 16 - Grasso, S., Messina, A., Saprite, N. : Serum insulin response to glucose and amino acids in the premature infant. Lancet 2, 755, 1968.
  • 17 - Grüttner, R. : Der Kohlenhydratstoffwechsel in der Neugeborenenleber. In Handbuch der Kinderheilkunde, Springer Verlag-Berlin. Band 1/2, 1971.
  • 18 - Gürgüç, A. : Doğum Operasyonları. A.Ü. Tıp Fakültesi Yayınları, Sayı 367, s. 95.
  • 19 - Harnachk V.G.A. : Kinderheilkunde. Springer-Berlin-New York, 1980.
  • 20 - Hatemi H., Ocak V., Atasu, T., Urgancıoğlu, İ. : Doğumdan hemen sonra anne ve kordon kanında şeker ve insülin değerleri. XVI. Türk Pediatri Kongresi “Perinatoloji Kitabı” Cilt I, 1978.
  • 21 - Haworth, J.C., Coodin, F.J., Finkel, K.G., Weidman, M.L. : Hypoglycemia associated with symptoms in the newborn period. Canad. Med. Ass. J. 88, 23, 1963.
  • 22 - Jarrett, J.R. : Reflections on gestational diabetes mellitus. Lancet 28, 1220, 1981.
  • 23 - Lacy, P.E., Hovell, S.L., Young, D.A., Fink, C.J. : New hypothesis of insulin secretion. Nature 219 : 1177, 1968.
  • 24 - Lind, T. et al. : A serial study of changes occurring in the oral glucose tolerance test during pregnancy. J. Obstet. Gynaecol. Brit. Commonwealth 80, 1033, 1973.
  • 25 - Lind, T. : Changes in carbohydrate metabolism during pregnancy. Clinics in Obstet. Gynaecol., Vol. 2, No. 2, 395, 1975.
  • 26 - Loevenich, V.V. : Diabetes mellitus in pregnancy. In Pharmakotherapie im Kindesalter, Hans Marseille Verlag, München, 1977.
  • 27 - Martin, H., Greenberg M.D. : Care of the low birth weight infant. Current Therapy, Ed. H.F. Cohn. Saunders Comp., 887, 1981.
  • 28 - Miething, R., Loevenich, V.V. : Blutzucker und Insulinspiegel bei Neugeborenen. Alete Reihe 3, 27, 1978.
  • 29 - Melichar, V. et al. : Die Entwicklung von Kindern mit Apgar 1 eine Minute nach der Geburt. Pädiat. Praxis 24, 601, 1981.
  • 30 - McCann, M.L. et al. : The prevention of hypoglycemia in infants of diabetic mothers. Soc. Ped. Res., 5, 1965.
  • 31 - Montgomery, D.A.D., Harley, J.M.G. : Endocrine Disorders. Clinics in Obstet. Gynaecol., Vol. 4, No. 2, 356, 1977.
  • 32 - Vaughan, C.V., McKay, J.R., Nelson, E.W. : Textbook of Pediatrics, W.B. Saunders Company, 1978-1980.
  • 33 - Öğütcü, O. : Yenidoğan kordon kanı plazmasında insülin ve glikoz seviyeleri. GATA İhtisas Tezi, 1977.
  • 34 - Pedersen, J. : Diabetes mellitus and pregnancy. Excerpta Medica, 678, 1971.
  • 35 - Schröter, W. : Die Neugeborenenhypoglykämie. In Handbuch der Kinderheilkunde, Springer Verlag-Berlin. Band 1/2, 1971.
  • 36 - Schröter, W. : Ernährung des Neugeborenen. Alete Reihe 2 : 20, 1978.
  • 37 - Simon, C. : Klinische Pädiatrie. Lehrbuch der Kinderheilkunde, Schattauer Verlag Stuttgart-New York, 1980.
  • 38 - Spellacy, W.N. et al. : Maternal, fetal and amniotic fluid levels of glucose, insulin and growth hormone. Obstet. Gynecol., 441 : 328, 1973.
  • 39 - Stubbe, P. : Glukagon, Insulin und Wachstumhormon-Bestimmungen bei Neugeborenen und Säuglingen. Alete Reihe 5 : 71, 1977.
  • 40 - Stimmler, L. : Plasma insulin levels in newborn infants of normal and diabetic mothers. The Lancet, January 1974.
  • 41 - Teller, W.M. : Hypoglykämien, Neugeborene. In Pharmakotherapie im Kindesalter, Hans Marseille Verlag, 1977.
  • 42 - Tuncer, M. : Diyabetli Anne Çocuğu. Ajans Türk Matbaası, Ankara, 1974.
  • 43 - Williams, R.H. : Textbook of Endocrinology. IX. ed. Saunders Comp., Philadelphia, 627, 1974.
  • 44 - Villee, C.A. et al. : Effects of anoxia on fetal tissue metabolism. Pediatrica, 22 : 953, 1958.
  • 45 - Cashore, W.J., Oh, W. : Normal infant feeding. Current Therapy, Ed. H.F. Cohn. Saunders Comp., 893, 1981.
  • 46 - White, P. : Pregnancy and diabetes. In Jarkin’s Diabetes Mellitus. Lea and Febiger, Philadelphia, 1971.

Normal Doğumda Anne ve Bebeğin Glukoz ve İnsülin Dinamikleri

Year 1982, Volume: 35 Issue: 1, 41 - 62, 31.03.1982

Abstract

This study investigates changes in maternal and neonatal glucose and insulin levels during normal delivery and the early postnatal period. In 38 healthy births, samples were taken at key time points—labor onset, time of birth, umbilical cord blood, and 30 minutes post-delivery from the newborn—to evaluate metabolic parameters with respect to labor duration and phase. Significant variations in glucose levels were observed across the labor phases, with a tendency toward hyperglycemia in prolonged labor. In contrast, insulin levels did not show significant changes. Regression analyses revealed that maternal glucose levels influenced neonatal glycemia. These findings highlight the impact of labor duration and maternal metabolic status on early neonatal glucose regulation.

References

  • 1 - Bachmann, K.D., Ewerbeck, H., Joppich, G. : Pädiatrie in der Praxis und Klinik : Gustav Fischer Verlag Stuttgart - New York. Cilt III, 1980.
  • 2 - Behrmann, E.R. : Neonatology. Diseases of the fetus and infant. The C.V. Mosby Company Saint Louis, 440, 1973.
  • 3 - Blunck, W. : Endokrines System : In Handbuch der Kinderheilkunde «Physiologie und pathologie der Neugetoronen periode», Springer Verlag-Berlin. Band 1/2, 82, 1971.
  • 4 - Buse, M.G., Roberts, W.J. : The role of placenta in the transfer and metabolism of insulin. J. Clin. Invest. 41 : 29, 1962.
  • 5 - Cornblath, M., Schwartz, R. : Disorders of carbohydrate metabolism in infancy III. Major problems in clinical pediatrics. p : 297, W.B. Saunders Co., 1966.
  • 6 - Cornblath, M., Reisner, S.H. : Blood glucose in the neonate clinical significance. New Engl. J. Med. 273-387, 1965.
  • 7 - Cornblath, M., Ganzon, A.F., Nicolopulos, D. et al. : Studies of carbohydrate metabolism in the newborn infant. Pediatrics, 27, 378, 1961.
  • 8 - Cornblath, M., Wybragt, S.H., Baens, G.S. : Studies of carbohydrate metabolism in the newborn infant. VII. Pediatrics 32, 1007, 1963.
  • 9 - Creery, R.D.G. : Hypoglycemia in the newborn. Lancet 1 : 1423, 1963.
  • 10 - Ditschuneit, F. : Insulin secretion in the newborn babies of normal and diabetic mothers. Acta Diab. Latina 5 supp. 319, 1968.
  • 11 - Dominick, H.Ch., Bachmann, K.D. : Die Hypoglykämie des Neugeborenen. Geburtshilfe und Frauenheilkunde, 39, 564, 1979.
  • 12 - Fanconi G., Wallgren A. : Lehrbuch der Pädiatrie, 9. Auflage, Schwabe Co Verlag. Basel/Stuttgart, 1980.
  • 13 - Felig, P. : Diabetes mellitus - fetal-maternal glucose insulin relationships. In Burrow and Ferris. Medical Complications During Pregnancy. W.B. Saunders Company, Ch 5, 171, 1975.
  • 14 - Feer E., Joppich, G., Schulte, J. : Lehrbuch der Kinderheilkunde, Gustav Fischer Verlag. Stuttgart, New York, 1980.
  • 15 - Girard, J., Stahl, M., Mars, P.W., Herz, G. : Hypoglykämie im Kindesalter. Pädiat. Praxis, 11 : 579, 1972.
  • 16 - Grasso, S., Messina, A., Saprite, N. : Serum insulin response to glucose and amino acids in the premature infant. Lancet 2, 755, 1968.
  • 17 - Grüttner, R. : Der Kohlenhydratstoffwechsel in der Neugeborenenleber. In Handbuch der Kinderheilkunde, Springer Verlag-Berlin. Band 1/2, 1971.
  • 18 - Gürgüç, A. : Doğum Operasyonları. A.Ü. Tıp Fakültesi Yayınları, Sayı 367, s. 95.
  • 19 - Harnachk V.G.A. : Kinderheilkunde. Springer-Berlin-New York, 1980.
  • 20 - Hatemi H., Ocak V., Atasu, T., Urgancıoğlu, İ. : Doğumdan hemen sonra anne ve kordon kanında şeker ve insülin değerleri. XVI. Türk Pediatri Kongresi “Perinatoloji Kitabı” Cilt I, 1978.
  • 21 - Haworth, J.C., Coodin, F.J., Finkel, K.G., Weidman, M.L. : Hypoglycemia associated with symptoms in the newborn period. Canad. Med. Ass. J. 88, 23, 1963.
  • 22 - Jarrett, J.R. : Reflections on gestational diabetes mellitus. Lancet 28, 1220, 1981.
  • 23 - Lacy, P.E., Hovell, S.L., Young, D.A., Fink, C.J. : New hypothesis of insulin secretion. Nature 219 : 1177, 1968.
  • 24 - Lind, T. et al. : A serial study of changes occurring in the oral glucose tolerance test during pregnancy. J. Obstet. Gynaecol. Brit. Commonwealth 80, 1033, 1973.
  • 25 - Lind, T. : Changes in carbohydrate metabolism during pregnancy. Clinics in Obstet. Gynaecol., Vol. 2, No. 2, 395, 1975.
  • 26 - Loevenich, V.V. : Diabetes mellitus in pregnancy. In Pharmakotherapie im Kindesalter, Hans Marseille Verlag, München, 1977.
  • 27 - Martin, H., Greenberg M.D. : Care of the low birth weight infant. Current Therapy, Ed. H.F. Cohn. Saunders Comp., 887, 1981.
  • 28 - Miething, R., Loevenich, V.V. : Blutzucker und Insulinspiegel bei Neugeborenen. Alete Reihe 3, 27, 1978.
  • 29 - Melichar, V. et al. : Die Entwicklung von Kindern mit Apgar 1 eine Minute nach der Geburt. Pädiat. Praxis 24, 601, 1981.
  • 30 - McCann, M.L. et al. : The prevention of hypoglycemia in infants of diabetic mothers. Soc. Ped. Res., 5, 1965.
  • 31 - Montgomery, D.A.D., Harley, J.M.G. : Endocrine Disorders. Clinics in Obstet. Gynaecol., Vol. 4, No. 2, 356, 1977.
  • 32 - Vaughan, C.V., McKay, J.R., Nelson, E.W. : Textbook of Pediatrics, W.B. Saunders Company, 1978-1980.
  • 33 - Öğütcü, O. : Yenidoğan kordon kanı plazmasında insülin ve glikoz seviyeleri. GATA İhtisas Tezi, 1977.
  • 34 - Pedersen, J. : Diabetes mellitus and pregnancy. Excerpta Medica, 678, 1971.
  • 35 - Schröter, W. : Die Neugeborenenhypoglykämie. In Handbuch der Kinderheilkunde, Springer Verlag-Berlin. Band 1/2, 1971.
  • 36 - Schröter, W. : Ernährung des Neugeborenen. Alete Reihe 2 : 20, 1978.
  • 37 - Simon, C. : Klinische Pädiatrie. Lehrbuch der Kinderheilkunde, Schattauer Verlag Stuttgart-New York, 1980.
  • 38 - Spellacy, W.N. et al. : Maternal, fetal and amniotic fluid levels of glucose, insulin and growth hormone. Obstet. Gynecol., 441 : 328, 1973.
  • 39 - Stubbe, P. : Glukagon, Insulin und Wachstumhormon-Bestimmungen bei Neugeborenen und Säuglingen. Alete Reihe 5 : 71, 1977.
  • 40 - Stimmler, L. : Plasma insulin levels in newborn infants of normal and diabetic mothers. The Lancet, January 1974.
  • 41 - Teller, W.M. : Hypoglykämien, Neugeborene. In Pharmakotherapie im Kindesalter, Hans Marseille Verlag, 1977.
  • 42 - Tuncer, M. : Diyabetli Anne Çocuğu. Ajans Türk Matbaası, Ankara, 1974.
  • 43 - Williams, R.H. : Textbook of Endocrinology. IX. ed. Saunders Comp., Philadelphia, 627, 1974.
  • 44 - Villee, C.A. et al. : Effects of anoxia on fetal tissue metabolism. Pediatrica, 22 : 953, 1958.
  • 45 - Cashore, W.J., Oh, W. : Normal infant feeding. Current Therapy, Ed. H.F. Cohn. Saunders Comp., 893, 1981.
  • 46 - White, P. : Pregnancy and diabetes. In Jarkin’s Diabetes Mellitus. Lea and Febiger, Philadelphia, 1971.
There are 46 citations in total.

Details

Primary Language English
Subjects Infant and Child Health
Journal Section Research Article
Authors

Fadıl Ertogan This is me

Publication Date March 31, 1982
Published in Issue Year 1982 Volume: 35 Issue: 1

Cite

APA Ertogan, F. (1982). Normal Doğumda Anne ve Bebeğin Glukoz ve İnsülin Dinamikleri. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 35(1), 41-62. https://izlik.org/JA43UA63PS
AMA 1.Ertogan F. Normal Doğumda Anne ve Bebeğin Glukoz ve İnsülin Dinamikleri. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1982;35(1):41-62. https://izlik.org/JA43UA63PS
Chicago Ertogan, Fadıl. 1982. “Normal Doğumda Anne Ve Bebeğin Glukoz Ve İnsülin Dinamikleri”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 35 (1): 41-62. https://izlik.org/JA43UA63PS.
EndNote Ertogan F (March 1, 1982) Normal Doğumda Anne ve Bebeğin Glukoz ve İnsülin Dinamikleri. Ankara Üniversitesi Tıp Fakültesi Mecmuası 35 1 41–62.
IEEE [1]F. Ertogan, “Normal Doğumda Anne ve Bebeğin Glukoz ve İnsülin Dinamikleri”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 35, no. 1, pp. 41–62, Mar. 1982, [Online]. Available: https://izlik.org/JA43UA63PS
ISNAD Ertogan, Fadıl. “Normal Doğumda Anne Ve Bebeğin Glukoz Ve İnsülin Dinamikleri”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 35/1 (March 1, 1982): 41-62. https://izlik.org/JA43UA63PS.
JAMA 1.Ertogan F. Normal Doğumda Anne ve Bebeğin Glukoz ve İnsülin Dinamikleri. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1982;35:41–62.
MLA Ertogan, Fadıl. “Normal Doğumda Anne Ve Bebeğin Glukoz Ve İnsülin Dinamikleri”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 35, no. 1, Mar. 1982, pp. 41-62, https://izlik.org/JA43UA63PS.
Vancouver 1.Ertogan F. Normal Doğumda Anne ve Bebeğin Glukoz ve İnsülin Dinamikleri. Ankara Üniversitesi Tıp Fakültesi Mecmuası [Internet]. 1982 Mar. 1;35(1):41-62. Available from: https://izlik.org/JA43UA63PS