Tween-60 (Polyoxyethylene Sorbitan Monostearate) Fare Derisinde Hiperplazi Doğuran Etkisi

Kadri Bacacı

TR EN

The Effect of Tween-60 (Polyoxyethylene Sorbitan Monostearate) Inducing Hyperplasia on Mouse Skin

Abstract

Dipole tip promotor maddelerden olan Tween-60 ın tekrarlayıcı tatbiklerinin fare derisinde meydana getirdiği hiperplazi etkisi araştırıldı ve neticeler literatürdekilerle karşılaştırıldı. Tween-60 ın sebep olduğu epidermal hücre değişiklikleri bilhassa diferansiye hücrelerde asırı bir çoğalmayı sağlıyordu. Bunu temin eden en az tatbikat sayısı 2-3 gün veya tatbikat olarak bulundu. 6 gün tatbikatla epidermiste (+ +++) şiddetinde bir hiperplazi teessüs etti. Bu hiperplazi diffüz, muntazam ve hücrelerde şişme ödem, hücreler arası mesafelerde genişleme, köprücükler teşekkülü ile karakterli idi. Tween-60 tatbikatının kesilmesi ile bu hiperplazinin 2--4 gün sonra tedricen gerilemeye başladığı ve 7-10 gün içinde kaybolarak epidermisin normal histolojik görünümünü aldığı tespit edildi. Neticede, başlangıçta günlük tatbikatlarla epidermiste 3--4 günde iyi bir hiperplazinin meydana getirilebileceği ve bunun 22 3 günlük fasılalarla yapılacak tek Tween-60 tatbikatları ile ayni derecede muhafaza edilebileceği kanısına varıldı. Bu neticenin deneysel deri karsinogenezi çalışmalarında Promotion olayını tetkik etmede metod yönünden önemli olabileceğj düşünüldü.

Keywords

Hiperplazi, Karsinogenez, Polyoxyethylene Sorbitan Monostearate

Tween-60 (Polyoxyethylene Sorbitan Monostearate) Fare Derisinde Hiperplazi Doğuran Etkisi

Abstract

Hyperplastic effect of repeated applications of Tween-60 onto the mouse skin has been investigated, and results compared with those reported in the literatüre. The cellular changes in the epidermis were consisted of marked proliferation of the differentiated spinal cells. The least number of the application causing hiperplasia of epidermis was found to be 2-3 times. 6 applications were produced ( I I + ) severe epi„ dermal hiperplasia. This was diffuse, regular, and characterised by cellular swelling, edema, expansion in the intercellular spaces, and also exageration of the intercellular bridges. With the interruption of Tween-60 applications, this hyperplasia was regressed gradually and disappeared through seventh to tenth days, and the histologic appearence of the epidermis was returned to mal. In this way, it is said that, a nice epidermal hyperplasia can be produced by daily application of Tween-60 within 3-4 days. Its severity can be keep up at the same level for a long time by single application every other day or 3 days interval. This finding was found to be important in respect to method of determination of promotion in the studies on experimental carcinogenesis.

Keywords

Hyperplasia, Carcinogenesis, Polyoxyethylene Sorbitan Monostearate

References

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Details

Primary Language

English

Subjects

Anatomy

Journal Section

Research Article

Authors

Kadri Bacacı ^* This is me
Türkiye

Publication Date

February 28, 1971

Submission Date

January 1, 1971

Acceptance Date

February 28, 1971

Published in Issue

Year 1971 Volume: 24 Number: 1

IZ

https://izlik.org/JA43LM64PG

APA

Bacacı, K. (1971). Tween-60 (Polyoxyethylene Sorbitan Monostearate) Fare Derisinde Hiperplazi Doğuran Etkisi. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 24(1), 1-14. https://izlik.org/JA43LM64PG

AMA

1.Bacacı K. Tween-60 (Polyoxyethylene Sorbitan Monostearate) Fare Derisinde Hiperplazi Doğuran Etkisi. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1971;24(1):1-14. https://izlik.org/JA43LM64PG

Chicago

Bacacı, Kadri. 1971. “Tween-60 (Polyoxyethylene Sorbitan Monostearate) Fare Derisinde Hiperplazi Doğuran Etkisi”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 24 (1): 1-14. https://izlik.org/JA43LM64PG.

EndNote

Bacacı K (February 1, 1971) Tween-60 (Polyoxyethylene Sorbitan Monostearate) Fare Derisinde Hiperplazi Doğuran Etkisi. Ankara Üniversitesi Tıp Fakültesi Mecmuası 24 1 1–14.

IEEE

[1]K. Bacacı, “Tween-60 (Polyoxyethylene Sorbitan Monostearate) Fare Derisinde Hiperplazi Doğuran Etkisi”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 24, no. 1, pp. 1–14, Feb. 1971, [Online]. Available: https://izlik.org/JA43LM64PG

ISNAD

Bacacı, Kadri. “Tween-60 (Polyoxyethylene Sorbitan Monostearate) Fare Derisinde Hiperplazi Doğuran Etkisi”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 24/1 (February 1, 1971): 1-14. https://izlik.org/JA43LM64PG.

JAMA

1.Bacacı K. Tween-60 (Polyoxyethylene Sorbitan Monostearate) Fare Derisinde Hiperplazi Doğuran Etkisi. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1971;24:1–14.

MLA

Bacacı, Kadri. “Tween-60 (Polyoxyethylene Sorbitan Monostearate) Fare Derisinde Hiperplazi Doğuran Etkisi”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 24, no. 1, Feb. 1971, pp. 1-14, https://izlik.org/JA43LM64PG.

Vancouver

1.Kadri Bacacı. Tween-60 (Polyoxyethylene Sorbitan Monostearate) Fare Derisinde Hiperplazi Doğuran Etkisi. Ankara Üniversitesi Tıp Fakültesi Mecmuası [Internet]. 1971 Feb. 1;24(1):1-14. Available from: https://izlik.org/JA43LM64PG

The Effect of Tween-60 (Polyoxyethylene Sorbitan Monostearate) Inducing Hyperplasia on Mouse Skin

Abstract

Keywords

Tween-60 (Polyoxyethylene Sorbitan Monostearate) Fare Derisinde Hiperplazi Doğuran Etkisi

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

IZ

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