Bir Tek Alçak Doz Karsinojenin Fare Epidermisindeki Etkileri ve Değişikliklerin Devamlılığı

Kadri Bacacı

EN TR

Bir Tek Alçak Doz Karsinojenin Fare Epidermisindeki Etkileri ve Değişikliklerin Devamlılığı

Abstract

The histological changes and their durability caused by a single low dose of carcinogen on the mouse skin were investigated. The findings were compared with those reported in the literature. Single application of the low dose carcinogen was caused cellular changes in the mouse epidermis. At the first few week after the application, the histological changes in the epidermis were seen easily by the light microscope. These changes were focal proliferation and increased mitosis in the basal layer cells. After second week, differantiated spinal cells were also proliferated slightly. This was related to the differentiation of spinal cells arised from increased basal layer cells. The epidermal cell changes caused by carcinogens were also seen on fourth week. But, on the sixth week, the histolojik appearence of the epidermis was returned to normal. After fourth week, histological signs of carcinogen was gradually regressed and disappeared on sixth week. Above mentioned cellular changes in the epidermis were not seen in the control animals.

Keywords

Başlangıç, Morphological Changes, Latent Tumor Cell

The Effects of a Single Low Dose Carcinogen on the Mouse Epidermis and the Persistence of Changes

Abstract

Bir tek alçak doz karsinojenin fare epidermisinde yaptzğı histolojik değişiklikler ve bunların devamlılık süreleri incelendi. Bulgular literatürdekilerle karşılaştırıldı. Bu alçak tek doz karsinojenin derideki epidermal hücrelerde ilk haftalar mikroskopla kolaylıkla görülebilecek şekilde histolojik değişikliklere sebep olduğu görüldü. Bu değişiklikler bazal hücrelerde mitoz artımı ile birlikte proliferasyon odakları şeklinde kendini gösterdi. İkinci haftadan sonra epidermisde bazal hücre proliferasyonu yanında spinal hücrelerde de hafif bir artış kaydedildiki bu da artan bazal hücrelerin neticede diferansiye olarak spinal hücreleri meydana getirmelerine bağlandı. Epidermal hücrelerde karsinojenin sebep olduğu değişiklikler 4. haftada da kendini göstermekte devam etti. 6. haftada epidermis normal yapısından histolojik olarak ayrılamıyacak bir duruma döndü. Karsinojenin histolojik olarak görülebilen belirtileri 4. haftadan sonra tedricen geriliyerek 6. haftada ortadan kayboldular. Yukarda belirtilen epidermal hücre değişikliklerinin kontrol hayvarılarmda görülmeyişi bulguların önemini ortaya koymaktadır.

Keywords

İnitiation, Morfolojik Değişiklikler, Latent Tümör Hücresi

References

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Details

Primary Language

English

Subjects

Pathology

Journal Section

Research Article

Authors

Kadri Bacacı ^* This is me
Türkiye

Publication Date

February 28, 1971

Submission Date

January 1, 1971

Acceptance Date

February 28, 1971

Published in Issue

Year 1971 Volume: 24 Number: 1

IZ

https://izlik.org/JA66EE94TA

APA

Bacacı, K. (1971). Bir Tek Alçak Doz Karsinojenin Fare Epidermisindeki Etkileri ve Değişikliklerin Devamlılığı. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 24(1), 15-27. https://izlik.org/JA66EE94TA

AMA

1.Bacacı K. Bir Tek Alçak Doz Karsinojenin Fare Epidermisindeki Etkileri ve Değişikliklerin Devamlılığı. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1971;24(1):15-27. https://izlik.org/JA66EE94TA

Chicago

Bacacı, Kadri. 1971. “Bir Tek Alçak Doz Karsinojenin Fare Epidermisindeki Etkileri Ve Değişikliklerin Devamlılığı”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 24 (1): 15-27. https://izlik.org/JA66EE94TA.

EndNote

Bacacı K (February 1, 1971) Bir Tek Alçak Doz Karsinojenin Fare Epidermisindeki Etkileri ve Değişikliklerin Devamlılığı. Ankara Üniversitesi Tıp Fakültesi Mecmuası 24 1 15–27.

IEEE

[1]K. Bacacı, “Bir Tek Alçak Doz Karsinojenin Fare Epidermisindeki Etkileri ve Değişikliklerin Devamlılığı”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 24, no. 1, pp. 15–27, Feb. 1971, [Online]. Available: https://izlik.org/JA66EE94TA

ISNAD

Bacacı, Kadri. “Bir Tek Alçak Doz Karsinojenin Fare Epidermisindeki Etkileri Ve Değişikliklerin Devamlılığı”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 24/1 (February 1, 1971): 15-27. https://izlik.org/JA66EE94TA.

JAMA

1.Bacacı K. Bir Tek Alçak Doz Karsinojenin Fare Epidermisindeki Etkileri ve Değişikliklerin Devamlılığı. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1971;24:15–27.

MLA

Bacacı, Kadri. “Bir Tek Alçak Doz Karsinojenin Fare Epidermisindeki Etkileri Ve Değişikliklerin Devamlılığı”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 24, no. 1, Feb. 1971, pp. 15-27, https://izlik.org/JA66EE94TA.

Vancouver

1.Kadri Bacacı. Bir Tek Alçak Doz Karsinojenin Fare Epidermisindeki Etkileri ve Değişikliklerin Devamlılığı. Ankara Üniversitesi Tıp Fakültesi Mecmuası [Internet]. 1971 Feb. 1;24(1):15-27. Available from: https://izlik.org/JA66EE94TA

Bir Tek Alçak Doz Karsinojenin Fare Epidermisindeki Etkileri ve Değişikliklerin Devamlılığı

Abstract

Keywords

The Effects of a Single Low Dose Carcinogen on the Mouse Epidermis and the Persistence of Changes

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

IZ

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