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Bir Tek Alçak Doz Karsinojenin Fare Epidermisindeki Etkileri ve Değişikliklerin Devamlılığı

Year 1971, Volume: 24 Issue: 1, 15 - 27, 28.02.1971

Kadri Bacacı

https://izlik.org/JA66EE94TA

Abstract

The histological changes and their durability caused by a single low dose of carcinogen on the mouse skin were investigated. The findings were compared with those reported in the literature.
Single application of the low dose carcinogen was caused cellular changes in the mouse epidermis. At the first few week after the application, the histological changes in the epidermis were seen easily by the light microscope. These changes were focal proliferation and increased mitosis in the basal layer cells. After second week, differantiated spinal cells were also proliferated slightly. This was related to the differentiation of spinal cells arised from increased basal layer cells. The epidermal cell changes caused by carcinogens were also seen on fourth week. But, on the sixth week, the histolojik appearence of the epidermis was returned to normal. After fourth week, histological signs of carcinogen was gradually regressed and disappeared on sixth week. Above mentioned cellular changes in the epidermis were not seen in the control animals.

Keywords

Başlangıç Morphological Changes Latent Tumor Cell

References

  • 1 — ANDREASEN, E. : Cyclic Changes in The Skin of Mouse, Acta Path. Mic. Scand. 32 : 157, 1953
  • 2 — ANDREASEN, E. and BOR.UM, K. : Histology of Early Reactions Following A Single Application of 9.10 Dimethyl 1.2 Benzanthracene to Mouse Skin in Two Different Stages of Hair Formation. Acta Path. Mic. Scand. 46 : 51, 1959
  • 3 — BERENBLüM, r. and SHUBiK, P. : A New, Quantitative, Approach to The Study of Chemical Carcinogenesis in The Mouse's Skin. Brit. J. Cancer 1 : 383, 1947
  • 4 — BERENBLUM, 1. : Cocarcinogenesis. Brit. Med. Bull. 4 : 343,1947
  • 5 — BERENBLUM, 1. : Carcinogenesis and Tumor Pathogenesis. Advances in Cancer Res. 2 : 29, 1954
  • 6 BERENBLUM, 1., HARAN-GHERA, N. and TRAiNiN, N. : An Ex. perimental Analysis of The ((1--lair Cycle Effect» in Mouse Skin Car. cinogenesis. Brit. J. Cancer 12 : 402, 1958
  • 7 — BERENBLUM, 1. : Soma New Implications of The Two - stage Mec. hanism in The Study of Skin Carcinogenesis. Mechanism of Action. Ciba Foundation Symposium on Carcinogenesis, s • 55, Little. Brown co., 1958
  • 8 — BERENBLUM, 1. Cellular Control Mechanisms and Cancer. The Two Stage Mechanism of Carcinogenesis as An Analytical Tool. Elsevier Publishing Co., 1964
  • 9 — BERG, N. O. : Comparison of The Epidermal Hiperplasia in The Skin on Mice After Application of Carcinogenic and Noncarcinogenic Irritants. Acta Path. Mic. Scand. 25 : 34, 1948
  • 10 — BOCK, F.G. : Species Differences in Penetration and Absorbtion of Chemical Carcinogens. Nat. Cancer Inst. Monog. 10 361, 1963
  • 11 — BORUM, K. : The Role of The Mouse Hair cycle in Epidermal co. carcinogenesis. Acta Path. Mic. Scand. 34 • 542, 1954
  • 12 BRADBURY, J.T., BACHMANN, W. E. and LEWiSOHN, M. G. : The Production of Cancer by Some New Chemical Compounds. Factors Affecting The Latent Period of Tumor Production. Cancer Res. 1 685, 1941
  • 13 — COMAN, DR. : Reduction in Cellular Adhesiveness Upon Contact With A Carcinogen. Cancer Res. 20 • 1202, 1960
  • 14 — COWDRY, E.V. : Epidermal Carcinogenesis. Advances in Cancer Res. 1 : 57, 1953
  • 15 — CRAMER, W. and STOWFLL, R. E. : The Early Stages of Carcinogenesis by 20 Methylcholanthrane in Skin of The Mouse. Il. Microscopic Tissue Changes. J. Nat. Cancer Inst. 2 : 379, 1942
  • 16 — DAMMERT, K. : Zur Histology Der Chemichen Hautcarcinogenese 1m Lichte Der Zwei Phasen Hypothese Untersucht on Mâusen. Acta Path. Mic. Scand. Suppl. 124, 1957
  • 17 — DAMMERT, K. : A Histological and Cytological Study of Different Methods of Skin Tumorigenesis in Mice. Acta Path. Mich. Scand 53 • 33, 1961
  • 18 — DARCHUM, V. and HADLER, H. 1. : Metabolic and Carcinogenic Studies With 9. 10 Dimethyl 1.2 Benzanthracene. Cancer Res. 16 316, 1956
  • 19 — DAVÏBHADHANA, B. : Numerical Proportions of Different Cells in Mouse Epidermis During Early Methylcholanthrene Carcinogenesis. Cancer Res. 12 • 165, 1952
  • 20 — EVENSEN, A. : Experimental Skin Carcinogenesis in Mice. Part 11. Effecte of Carcinogens on Cell Proliferation. Acta Path. Mic. Ccand. Suppl. 156 • 95, 1962
  • 21 — GLÜCKSMANN, A. : The Histogenesis Benzpyrene-induced Epidermal Tumors in The Mouse. Cancer Res. 5 : 385, 1945
  • 22 — GLÜCKSMANN, A. : Epitelial Tissue of The Skin During Carcinogenesis. Nat. Cancer Inst. Monog. 10 • 509, 1962
  • 23 HEiDELBERGER, C. : Some Reflections and speculations About Chemical Carcinogenesis. Canad. Cancer Conf. : 326, 1967
  • 24 HiEGER, I. : Theories of Carcinogenesis, Academic Presss, 1961
  • 25 IVERSEN, and ARLËŸ, N. : Mechanism of Experimental Carcinoge nesis. Acta Path. Mie. Scand. 27 : '773, 1950
  • 26 — IVERSEN, S. and EDELSTEiN, J. M. : Mechanism of Experimental Carcinogenesis; Early Mitotic Effect of 9. 10 Dimethyl 1. 2 benzanth. racene and 1. 2. 5. 6 Dibenzanthracene on Epidermal Cells of Mouse Ear. Acta Path. Mic. Scand. 30 • 213, 1952
  • 27 — IVERSEN, O. H. : Experimental Skin Carcinogenesis in Mice. Part I. Effects of Carcinogens on Mitochondrial Function. Acta Path. Mic. Scand. suppl 156 : 26, 1962
  • 28 KLEtN, M. : Induction in Mouse with Minute Doses of 9.10 dimethyl 12 benzanthracene Alone or Croton Oil. Cancer Res. 16 123, 1956
  • 29 — KLiNKEN-RASMUSSEN, L. : Quantitative Morphological Studies on Cyclic Changes in The Mouse Skin with Special Reference to Carcinogenesis. 1. Cell Counts in The Epidermis and Hair Follicles During The First Two Hair Cycles. Acta Path. Mic. Scand. 34 • 313, 1954
  • 30 — KLiNKEN - RASMUSSEN, L. : Quantitative Morphological Studies on Cyclic Changes in The Mouse Skin with Special Reference to Carcinogenesis. 4. Thickness of The Epidermis During The First Two Hair Cycles. Acta Path. Mice Scand 36 : 525, 1955
  • 31 — KLÏNKEN -RASMUSSEN, L. : Quantitative Morphological Studies ono Cyclic Changes in The Mouse Skin with Special Reference to Carcinogenesis. 3. Size and Number of Sebaceous Glands During The First Two Hair Cycles. Acta Path. Mic. Scand. 36 : 113, 1955
  • 32 LAW, L. W. ; Multiple Skin Tumors in Mice Following A single Pa inting with 9.10 Dimethyl 1.2 benzanthracene. Amer. J. Path. Il : 827, 1941

The Effects of a Single Low Dose Carcinogen on the Mouse Epidermis and the Persistence of Changes

Year 1971, Volume: 24 Issue: 1, 15 - 27, 28.02.1971

Kadri Bacacı

https://izlik.org/JA66EE94TA

Abstract

Bir tek alçak doz karsinojenin fare epidermisinde yaptzğı histolojik değişiklikler ve bunların devamlılık süreleri incelendi. Bulgular literatürdekilerle karşılaştırıldı.
Bu alçak tek doz karsinojenin derideki epidermal hücrelerde ilk haftalar mikroskopla kolaylıkla görülebilecek şekilde histolojik değişikliklere sebep olduğu görüldü. Bu değişiklikler bazal hücrelerde mitoz artımı ile birlikte proliferasyon odakları şeklinde kendini gösterdi. İkinci haftadan sonra epidermisde bazal hücre proliferasyonu yanında spinal hücrelerde de hafif bir artış kaydedildiki bu da artan bazal hücrelerin neticede diferansiye olarak spinal hücreleri meydana getirmelerine bağlandı. Epidermal hücrelerde karsinojenin sebep olduğu değişiklikler 4. haftada da kendini göstermekte devam etti. 6. haftada epidermis normal yapısından histolojik olarak ayrılamıyacak bir duruma döndü. Karsinojenin histolojik olarak görülebilen belirtileri 4. haftadan sonra tedricen geriliyerek 6. haftada ortadan kayboldular. Yukarda belirtilen epidermal hücre değişikliklerinin kontrol hayvarılarmda görülmeyişi bulguların önemini ortaya koymaktadır.

Keywords

İnitiation Morfolojik Değişiklikler Latent Tümör Hücresi

References

  • 1 — ANDREASEN, E. : Cyclic Changes in The Skin of Mouse, Acta Path. Mic. Scand. 32 : 157, 1953
  • 2 — ANDREASEN, E. and BOR.UM, K. : Histology of Early Reactions Following A Single Application of 9.10 Dimethyl 1.2 Benzanthracene to Mouse Skin in Two Different Stages of Hair Formation. Acta Path. Mic. Scand. 46 : 51, 1959
  • 3 — BERENBLüM, r. and SHUBiK, P. : A New, Quantitative, Approach to The Study of Chemical Carcinogenesis in The Mouse's Skin. Brit. J. Cancer 1 : 383, 1947
  • 4 — BERENBLUM, 1. : Cocarcinogenesis. Brit. Med. Bull. 4 : 343,1947
  • 5 — BERENBLUM, 1. : Carcinogenesis and Tumor Pathogenesis. Advances in Cancer Res. 2 : 29, 1954
  • 6 BERENBLUM, 1., HARAN-GHERA, N. and TRAiNiN, N. : An Ex. perimental Analysis of The ((1--lair Cycle Effect» in Mouse Skin Car. cinogenesis. Brit. J. Cancer 12 : 402, 1958
  • 7 — BERENBLUM, 1. : Soma New Implications of The Two - stage Mec. hanism in The Study of Skin Carcinogenesis. Mechanism of Action. Ciba Foundation Symposium on Carcinogenesis, s • 55, Little. Brown co., 1958
  • 8 — BERENBLUM, 1. Cellular Control Mechanisms and Cancer. The Two Stage Mechanism of Carcinogenesis as An Analytical Tool. Elsevier Publishing Co., 1964
  • 9 — BERG, N. O. : Comparison of The Epidermal Hiperplasia in The Skin on Mice After Application of Carcinogenic and Noncarcinogenic Irritants. Acta Path. Mic. Scand. 25 : 34, 1948
  • 10 — BOCK, F.G. : Species Differences in Penetration and Absorbtion of Chemical Carcinogens. Nat. Cancer Inst. Monog. 10 361, 1963
  • 11 — BORUM, K. : The Role of The Mouse Hair cycle in Epidermal co. carcinogenesis. Acta Path. Mic. Scand. 34 • 542, 1954
  • 12 BRADBURY, J.T., BACHMANN, W. E. and LEWiSOHN, M. G. : The Production of Cancer by Some New Chemical Compounds. Factors Affecting The Latent Period of Tumor Production. Cancer Res. 1 685, 1941
  • 13 — COMAN, DR. : Reduction in Cellular Adhesiveness Upon Contact With A Carcinogen. Cancer Res. 20 • 1202, 1960
  • 14 — COWDRY, E.V. : Epidermal Carcinogenesis. Advances in Cancer Res. 1 : 57, 1953
  • 15 — CRAMER, W. and STOWFLL, R. E. : The Early Stages of Carcinogenesis by 20 Methylcholanthrane in Skin of The Mouse. Il. Microscopic Tissue Changes. J. Nat. Cancer Inst. 2 : 379, 1942
  • 16 — DAMMERT, K. : Zur Histology Der Chemichen Hautcarcinogenese 1m Lichte Der Zwei Phasen Hypothese Untersucht on Mâusen. Acta Path. Mic. Scand. Suppl. 124, 1957
  • 17 — DAMMERT, K. : A Histological and Cytological Study of Different Methods of Skin Tumorigenesis in Mice. Acta Path. Mich. Scand 53 • 33, 1961
  • 18 — DARCHUM, V. and HADLER, H. 1. : Metabolic and Carcinogenic Studies With 9. 10 Dimethyl 1.2 Benzanthracene. Cancer Res. 16 316, 1956
  • 19 — DAVÏBHADHANA, B. : Numerical Proportions of Different Cells in Mouse Epidermis During Early Methylcholanthrene Carcinogenesis. Cancer Res. 12 • 165, 1952
  • 20 — EVENSEN, A. : Experimental Skin Carcinogenesis in Mice. Part 11. Effecte of Carcinogens on Cell Proliferation. Acta Path. Mic. Ccand. Suppl. 156 • 95, 1962
  • 21 — GLÜCKSMANN, A. : The Histogenesis Benzpyrene-induced Epidermal Tumors in The Mouse. Cancer Res. 5 : 385, 1945
  • 22 — GLÜCKSMANN, A. : Epitelial Tissue of The Skin During Carcinogenesis. Nat. Cancer Inst. Monog. 10 • 509, 1962
  • 23 HEiDELBERGER, C. : Some Reflections and speculations About Chemical Carcinogenesis. Canad. Cancer Conf. : 326, 1967
  • 24 HiEGER, I. : Theories of Carcinogenesis, Academic Presss, 1961
  • 25 IVERSEN, and ARLËŸ, N. : Mechanism of Experimental Carcinoge nesis. Acta Path. Mie. Scand. 27 : '773, 1950
  • 26 — IVERSEN, S. and EDELSTEiN, J. M. : Mechanism of Experimental Carcinogenesis; Early Mitotic Effect of 9. 10 Dimethyl 1. 2 benzanth. racene and 1. 2. 5. 6 Dibenzanthracene on Epidermal Cells of Mouse Ear. Acta Path. Mic. Scand. 30 • 213, 1952
  • 27 — IVERSEN, O. H. : Experimental Skin Carcinogenesis in Mice. Part I. Effects of Carcinogens on Mitochondrial Function. Acta Path. Mic. Scand. suppl 156 : 26, 1962
  • 28 KLEtN, M. : Induction in Mouse with Minute Doses of 9.10 dimethyl 12 benzanthracene Alone or Croton Oil. Cancer Res. 16 123, 1956
  • 29 — KLiNKEN-RASMUSSEN, L. : Quantitative Morphological Studies on Cyclic Changes in The Mouse Skin with Special Reference to Carcinogenesis. 1. Cell Counts in The Epidermis and Hair Follicles During The First Two Hair Cycles. Acta Path. Mic. Scand. 34 • 313, 1954
  • 30 — KLiNKEN - RASMUSSEN, L. : Quantitative Morphological Studies on Cyclic Changes in The Mouse Skin with Special Reference to Carcinogenesis. 4. Thickness of The Epidermis During The First Two Hair Cycles. Acta Path. Mice Scand 36 : 525, 1955
  • 31 — KLÏNKEN -RASMUSSEN, L. : Quantitative Morphological Studies ono Cyclic Changes in The Mouse Skin with Special Reference to Carcinogenesis. 3. Size and Number of Sebaceous Glands During The First Two Hair Cycles. Acta Path. Mic. Scand. 36 : 113, 1955
  • 32 LAW, L. W. ; Multiple Skin Tumors in Mice Following A single Pa inting with 9.10 Dimethyl 1.2 benzanthracene. Amer. J. Path. Il : 827, 1941
There are 32 citations in total.

Details

Primary Language English
Subjects Pathology
Journal Section Research Article
Authors

Kadri Bacacı This is me

Publication Date February 28, 1971
IZ https://izlik.org/JA66EE94TA
Published in Issue Year 1971 Volume: 24 Issue: 1

Cite

APA Bacacı, K. (1971). Bir Tek Alçak Doz Karsinojenin Fare Epidermisindeki Etkileri ve Değişikliklerin Devamlılığı. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 24(1), 15-27. https://izlik.org/JA66EE94TA
AMA 1.Bacacı K. Bir Tek Alçak Doz Karsinojenin Fare Epidermisindeki Etkileri ve Değişikliklerin Devamlılığı. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1971;24(1):15-27. https://izlik.org/JA66EE94TA
Chicago Bacacı, Kadri. 1971. “Bir Tek Alçak Doz Karsinojenin Fare Epidermisindeki Etkileri Ve Değişikliklerin Devamlılığı”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 24 (1): 15-27. https://izlik.org/JA66EE94TA.
EndNote Bacacı K (February 1, 1971) Bir Tek Alçak Doz Karsinojenin Fare Epidermisindeki Etkileri ve Değişikliklerin Devamlılığı. Ankara Üniversitesi Tıp Fakültesi Mecmuası 24 1 15–27.
IEEE [1]K. Bacacı, “Bir Tek Alçak Doz Karsinojenin Fare Epidermisindeki Etkileri ve Değişikliklerin Devamlılığı”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 24, no. 1, pp. 15–27, Feb. 1971, [Online]. Available: https://izlik.org/JA66EE94TA
ISNAD Bacacı, Kadri. “Bir Tek Alçak Doz Karsinojenin Fare Epidermisindeki Etkileri Ve Değişikliklerin Devamlılığı”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 24/1 (February 1, 1971): 15-27. https://izlik.org/JA66EE94TA.
JAMA 1.Bacacı K. Bir Tek Alçak Doz Karsinojenin Fare Epidermisindeki Etkileri ve Değişikliklerin Devamlılığı. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1971;24:15–27.
MLA Bacacı, Kadri. “Bir Tek Alçak Doz Karsinojenin Fare Epidermisindeki Etkileri Ve Değişikliklerin Devamlılığı”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 24, no. 1, Feb. 1971, pp. 15-27, https://izlik.org/JA66EE94TA.
Vancouver 1.Kadri Bacacı. Bir Tek Alçak Doz Karsinojenin Fare Epidermisindeki Etkileri ve Değişikliklerin Devamlılığı. Ankara Üniversitesi Tıp Fakültesi Mecmuası [Internet]. 1971 Feb. 1;24(1):15-27. Available from: https://izlik.org/JA66EE94TA