Mitral Darlığı ve Yetmezliğinde Lanatocide C ile Akut Digitalizasyonun Sağ ve Sol Ventrikül Hemodinamiği Üzerine Etkisi

Year 1968, Volume: 21 Issue: 3, 753 - 777, 30.09.1968

Sabahat Kaymakçalan

https://izlik.org/JA87GL74GA

Abstract

1 14 mitral darlığı ve 4 mitral yetmezliği vakasında kombine sağ ve sol kalb kateterizasyonu ile Lanatoside C ile akut digitalizasyonu sağ ve sol kalb hemodinamiğine tesiri incelendi.
2 Kalb için basınçlarıyla birlikte apeksten alınan fonokardiyogram ve DLI derivasyonu ile EKG de alındı ve traselerin kıymetdirilmesinde faydalanıldı.
Çalışmada hastalar istirah halinde iken 30 daika ara ile iki defa basınç ve debi traseleri elde edildi. Bu rakkamların ortalamaları başlangıç kıymetleri olarak alındıktan sonra Art. pulmonalise 1.2 m.gr. Ceto şanol 5 dakikada zerkedilerek 30, 60 ve 90 ıncı dakikalarda basınçlar ve debi tekrarlandı. Debiler boyu dilüsyon metodu kullanıldı.
4 Netice olarak, elde edilen kıymetlere göre mitral yetmez liği vakalaxırmzın adedi az olmakl aberaber mitral darlığında ve yet mezliğinde elde edilen neticelerin birbirine uyduğu,
5 — Mitral valvül hastalığında kalb döneminin sistoik safhalarrnın normallere nazaran uzamış bulunduğu,
6 — Akut digitalizasyonun yetmezlik içinde olmayan mitral hastalarında da EMS, IHZ, EZi'nin öenmli derecede kısatarak ve diyastolik komponentlerde uzama husule getirerek sol ventrikülün diyastol sonu basıncını düşürdüğü,
7 — Sol atrium pulmoner venöz kapiller ve pulmoner arter ortalama basınçlarında fazla bir değişiklik yapmadığı,
8 — Sol atrium basınç trasesinde «a» dalgasını, yani, sol atrium kontraksiyonunu hafif arttırdığını, buna mukabil «v» dalgasında hafif bir düşme tevlit ettiği,
9 — Bu muhtelif parametrelere digitaljn yukarıdaki tesirlerinin, myokardın kontraktil kuvvetini arttırmak suretiyle pozitif inotropik bir etki vasıtasile olduğu kanaatma varılmıştır.

Keywords

mitral darlık , lanatocide c , akut digitalizasyon

Supporting Institution

ANKARA ÜNİVERİSTESİ TIP FAKÜLTESİ

WITH LANATOCiDE C IN MITRAL STENOSIS AND INSUFFICIENCY EFFECT OF ACUTE DIGITALIZATION ON RIGHT AND LEFT VENTRICULAR HEMODYNAMICS

https://izlik.org/JA87GL74GA

Abstract

1 — The response to acute digitalization in compansated_14 mitral stenosis and 4 mitral insufficiency cases was not different from each other.
2 — The systolic phases of cardiac cycle was found to be prolonged in mitral valvular lesions.
3 — Acute digitalization decreased the electromechanical interval, isometric contraction time and ejection time index considerahly, prolonging the diastolic cornDonents and decreasing the and diastolic Dressures of the left ventricle in mitral natients.
4 — The left atrial, pulmonary capillary and pulmonary arterial mean oressures were not changed significantly.
5 — These results have Droved that acute digitalization has an inotropic positive effect on the nonfailing myocardium in mitral stenosis and insufficiency cases.
6 - Acute digitalization also reduces the end-diastolic pressure of the left ventricle by significantly shortening EMS, IHZ, EZI in mitral patients who are not in insufficiency and by bringing prolongation of diastolic components into consideration,
7 — The left atrium does not cause much change in the pulmonary venous capillary and pulmonary artery mean pressures.
8 — It slightly increases the «a» wave in the left atrium pressure trace, i.e., the left atrium contraction, and on the other hand, it causes a slight decrease in the «v» wave.
9 — It is believed that the above effects of digitaljn on these various parameters are through a positive inotropic effect by increasing the contractile force of the myocardium.

Keywords

MITRAL STENOSIS , LANATOCIDE C , ACUTE DIGITALIZATION

Supporting Institution

ANKARA ÜNİVERİSTESİ TIP FAKÜLTESİ

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