Research Article
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Cardiogenic Shock and Its Treatment

Year 1968, Volume: 21 Issue: 3, 957 - 970, 30.09.1968
https://izlik.org/JA37JP87ZH

Abstract

Clinical cardiogenic shock usually develops as a result of acute myocardial infarction, myocarditis, pulmonary emboly, paroxixmal tachycardias, pericardial tamponade, and heart blocks. it can also be observed in terminal period of the congestive heart failure. The basic cause of the fall of blood pressure, is primaly due to the 'inhibition of myocardial contractility. The cardiac index and the cardiac output are usually inhibited in the experimental and clinical shocks.
The peripheral resistance does not necessarily increase in every cases with falling blood pressure, such as in the adrenergic inhibition of a reflex mechanism which is originated from the damaged myocardial area.
Generally, the vasoconstrictor agents are used as a common treatment of the cardiogenic shock. tn addition of these beta adrenergic stimulating agents, alfa adrenergic blocking agents, on the other hand for the treatment of cardiac arrhytmias; beta adrenergic blocking agents have also been used. However using this scheme of treatment, the mortality is about % 60. Also it has been reported that counter-pulsation, by-pass of the left ventricule and venous-aortical shunt are in trial on the animals,

Supporting Institution

ANKARA ÜNİVERİSTESİ TIP FAKÜLTESİ

References

  • 1 — L.tLLE.HEt, R. C, LONGERBEAM, J., BLOCH, J. H., MANAX, W. G. : The nature of irreversible shock; Surg.,160 : 682, 1964.
  • 2 — MARSHALL, R. J., DARBY, T. D. : Shock, Pharmacological Principles in Treatment., Edited by Kugelmass, I. 36, 1966.
  • 3 — KUHN, L. A. : Treatment of cardiogenic shock; Mod. Treat; 4 : 299, 1967.
  • 4 — KUHN. L. A. : Editorial : Changing treatment of shock following acute myocardäal infarction, Am. J. Cardiol; 20 : 757, 1968.
  • 5 — SHUBtN, H., 'WEIL, M. H. : The treatment of shock complicating acute myocardial infarction; Prog. Cardiovas. Dis., 10 : 30, 1967.
  • 6 — SMITH, H. C., ORtOL, A., MORCH, J., MC. GREGOR, M. : Hemodina studies dn cardiogenic shock; Circulation., 85 : 1084, 1967.
  • 7 — KUHN, L.A. : Treatment of cardiogenic shock. Part I. The nature of cardiogenic sock; A.m. Heart. J., 74, 578, 1967. COHN, J. N. : Editorial : Myocardial infarction shock; Am. Heart. J., 74 : 1, 1967.
  • 9 — GUNNAR, R. M., CRUZ, A., BOSWELL, J., PtETRAS, J., TOBtN, J. R. : Myocardial infarction shock; œrculation. 33 : 753, 1966.
  • 10 — KURLAND, G. S., C., PITT, B. : The relation between tho location of coronanr aclusions and the cwcurence of shock in acute myocardial infarction; Circulation., 31 : 646, 1965.
  • 11 — IWH.N, L. A., KLINE, H. J., MARANS, A. J., HAMBY, R. 1., CESTÐRO, J. H., CHON. L. J., WEINRAUCHJ H., BERGER, M. : Mechanical increase of vasculere resistance in expertlmental myocardial infarctom with shock; Circ. Res., 19, 1086, 1966.
  • 12 — KUHN, L. A., ILtÑE, H. J., WANG, M., YAMAKt, T., JACOBSON, H. : Hemodinamic effects of hyperbaric oxyge nation in experimental acute myocardial infarction; Circ. Res., 16 : 499, 1965.
  • 13 — MOON, A. J., WTLLtAMS, K. G., HOPKINSON, W. 1. : A patient with coronary thrombosis treated with hyperbaric oxygenation; Lancet., I : 18, 1964.
  • 14 — NIXON, P. G. F., I.KRAM, H., S. : Preliminary communication: infusions of dextrose solution in cardiogenic shock; Lancet. I : 1077, 1966. 15 — LEADtNG ARTICLES : Treatment of cardiogenic shock; Lancet., 1 : 645, 1966.
  • 16 — DtETZMAN, R. H., LYONS, G. W., BLOCH, J. H., Ltl.LEHEt, R. C. : Relation of cardiac work to survival in cardiogenic shock In dogs; J. A.M. A., 199, 825, 1967. KARDtYOJENtK 90K TEDAvtst 969
  • 17 — AGRESS, C. M. : Therapy of cardiogenic shock; Progr. Cardiov. Dis., 6 : 236, 1963.
  • 18 — HOPKtNS, R. W., SAVGA, G., PENN, 1., SIMEONÐ, F. A. : Hemodÿnamic aspects of hemorrhagds and septic shock; J. A. M.A., 191: 731, 1965.
  • 19 — A Multicentre Trial : Propranolol in acute myocardial ffifarction; Lancet., 2 : 1435, 1966.
  • 20 — SELZER, A. : The hypotensive state following acute myocardial infarcti on I. Clinical observations; Amer. Heart. J., 44 : I, 1952. (Özet : MARSHALL, R. J., DARBY, T. D; Shock, Pharmacological Priciples in Treatment. Edited by Kugelmass, I. N., 36, 1966).
  • 21 TÜRKÐR, K. R. : Effect of angiotensin on the cerdiac arrhytmlag induced by g strophantin; Experientia. 20 : 707, 1965 . 22 Bn,TDER, M. J., RYAN, J. A., JR., MARCUS, S., MUGLER, F., JR., STRANGE, D., AGRESS, C. M. : mraluation of therapy in shock following acute myocardial infarction; Amer. J. Med. 18 : 622, 1955. (Özet MARSHALL, R. J., DARBY, T. D. ; Shock, Pharmacological Principles in Treatment., Edited by Kugelmass, I. Ñ., 36, 1966).
  • 23 — LILLEHEt, R. C., DIETZMAN, A. H., MOVSAS, S., BLOCH, J. H. : Treatment of septic shoc; Mod. Treat., 4 : 321, 1967.
  • 24 — MC. CLELLAND, R. N., SHtRËS, T., BAXTER, C. R., COLN, C. D, CARRtCO, J. : Balanced salt solution in the treatment of hemorrhagic shock; J. A. M. A., 199 : 830, 1967.
  • 25 — VICK, J. A. : Vasodilatator therapy in acute hemorrhagic shock; Circ. Res., 16 : 58, 1965.
  • 26 — MURPHY, G. W., GLICK, G., SCHREINER, B. F., JR., YU., YU, P. N. : Cardiac output in acute myocardial infarction. Serial determination by precordial radio-isotope dilation curve; Amer. J. Cardiol., 11 : 587, 1965.
  • 27 — MC. KANZIE, G. J., TAYLOR, S. H., FLENLEŸ, D. C., MC DONALD, A. H., STAUNTON, H. P., DONALD, K. W. : Circulation and respiratory studies in myocardial infarcton and cardiogentc shock; Lancet. 2 : 825, 1964.
  • 28 — HARDAWAY, R. M., JAMES, P. M., ANDERSON, R. W., BREDENBURG C. Pa., WEST, R. L. : intensive study and treatment of shock in man; J. A. M. A., 199 : 779, 1967.
  • 29 — DARBY, T. D, WATTS, D. T. : Acidosis and blood epinephrine levels in hemorrhagic hypotension; Amer. J. Physiol., 206 : 1281, 1964.
  • 30 — GUNTON, R. W., BEAULANDS, D. S. : Anglotensin in the treatment of following myocardial infarction; Amer. J. Cardiol., 14 : 370, 1964 970 GÜRLER tr.,tçtN
  • 31 — BRADLEY, B. C., w•ntr.4 M. B. : and vasodilatator dn.lgs tn the treatment of shock; Med. Treat., 4 : 243, 1967.
  • 32 — MA'ITHES, K. : Myocardial shock;- Shock Pathogenesis and Therapy, An international symposium., Stockholm, 27 th-30 th June 1961 Sponso red Ciba. Edited by Bock, K. D., 253, 1962.
  • 33 — WILSON, R. n, JABLOSRt, D. V., TH.AL, A. P. : Usage of dibenzyline in clinical shock; Surgery., 56 : 172, 1964.
  • 34 — NASH, C. B, CARTER, JR. : Hemorrhagic myocardit.is and cardiovascular collapse induced by catecholamine infusion; Arch. int. Pharmacodyn., 166 : 172, 1967.

KARDİYOJENİK ŞOK VE TEDAVİSİ

Year 1968, Volume: 21 Issue: 3, 957 - 970, 30.09.1968
https://izlik.org/JA37JP87ZH

Abstract

Klinikte kardiyojenik şok sıklıkla akut myokard infarktüsünden sonra, daha az oranda da, çeşitli sebeplere bağlı myokarditis, kalb tamponadı, pulmoner emboli, uzun süren paroksismal takikar diler, ve blokla müterafık kalb dakika atım sayısının ve atım volü« münün ileri derecede azalmasından meydana gelir. Konjestif kalb yetmezliğinin terminal devrelerinde de şok tablosu teessüs edebilir.
Akut myokard infarktüsünden sonra kalb kontraktilitesinin ileri derecede azalması, kan basıncı düşmesinden ön plânda sorumludur. Deneysel ve klinik kardiyojenik şok vak'alarda kalb atım
volümü, kardiyak index düşük seyretmektedir. Her vak'ada, kan basıncı düşmesi ile beraber vasküler rezistansln artmadlžl; bam hallerde, leze kalb sahasından kalkan reflekslerle adrenerjik sistern aktivitesinin inhibe edildiği bildirilmistir.
Tedavide, hâ.len vasokonstriktörler ön plânda kullanılmaktadırlar. Bunun yanl slra, beta reseptörleri stimüle eden ilâçlar, alfa adrencrjik bloke ediciler, aritmilerin düzeltilebilmesi bakımdan, beta adrenerjik bloke ediciler denenmislerdir. Bütün tedavi imkânlamna rağmen, halen mortalite % 60 civarındadır. Bu bakımdan, lâbaratuvarlarda, sol ventrikül by pass'l, counter-pulsation, kalp venlerden aortaya pompalanması, yöntemleri denenmektedirler.

Supporting Institution

ANKARA ÜNİVERİSTESİ TIP FAKÜLTESİ

References

  • 1 — L.tLLE.HEt, R. C, LONGERBEAM, J., BLOCH, J. H., MANAX, W. G. : The nature of irreversible shock; Surg.,160 : 682, 1964.
  • 2 — MARSHALL, R. J., DARBY, T. D. : Shock, Pharmacological Principles in Treatment., Edited by Kugelmass, I. 36, 1966.
  • 3 — KUHN, L. A. : Treatment of cardiogenic shock; Mod. Treat; 4 : 299, 1967.
  • 4 — KUHN. L. A. : Editorial : Changing treatment of shock following acute myocardäal infarction, Am. J. Cardiol; 20 : 757, 1968.
  • 5 — SHUBtN, H., 'WEIL, M. H. : The treatment of shock complicating acute myocardial infarction; Prog. Cardiovas. Dis., 10 : 30, 1967.
  • 6 — SMITH, H. C., ORtOL, A., MORCH, J., MC. GREGOR, M. : Hemodina studies dn cardiogenic shock; Circulation., 85 : 1084, 1967.
  • 7 — KUHN, L.A. : Treatment of cardiogenic shock. Part I. The nature of cardiogenic sock; A.m. Heart. J., 74, 578, 1967. COHN, J. N. : Editorial : Myocardial infarction shock; Am. Heart. J., 74 : 1, 1967.
  • 9 — GUNNAR, R. M., CRUZ, A., BOSWELL, J., PtETRAS, J., TOBtN, J. R. : Myocardial infarction shock; œrculation. 33 : 753, 1966.
  • 10 — KURLAND, G. S., C., PITT, B. : The relation between tho location of coronanr aclusions and the cwcurence of shock in acute myocardial infarction; Circulation., 31 : 646, 1965.
  • 11 — IWH.N, L. A., KLINE, H. J., MARANS, A. J., HAMBY, R. 1., CESTÐRO, J. H., CHON. L. J., WEINRAUCHJ H., BERGER, M. : Mechanical increase of vasculere resistance in expertlmental myocardial infarctom with shock; Circ. Res., 19, 1086, 1966.
  • 12 — KUHN, L. A., ILtÑE, H. J., WANG, M., YAMAKt, T., JACOBSON, H. : Hemodinamic effects of hyperbaric oxyge nation in experimental acute myocardial infarction; Circ. Res., 16 : 499, 1965.
  • 13 — MOON, A. J., WTLLtAMS, K. G., HOPKINSON, W. 1. : A patient with coronary thrombosis treated with hyperbaric oxygenation; Lancet., I : 18, 1964.
  • 14 — NIXON, P. G. F., I.KRAM, H., S. : Preliminary communication: infusions of dextrose solution in cardiogenic shock; Lancet. I : 1077, 1966. 15 — LEADtNG ARTICLES : Treatment of cardiogenic shock; Lancet., 1 : 645, 1966.
  • 16 — DtETZMAN, R. H., LYONS, G. W., BLOCH, J. H., Ltl.LEHEt, R. C. : Relation of cardiac work to survival in cardiogenic shock In dogs; J. A.M. A., 199, 825, 1967. KARDtYOJENtK 90K TEDAvtst 969
  • 17 — AGRESS, C. M. : Therapy of cardiogenic shock; Progr. Cardiov. Dis., 6 : 236, 1963.
  • 18 — HOPKtNS, R. W., SAVGA, G., PENN, 1., SIMEONÐ, F. A. : Hemodÿnamic aspects of hemorrhagds and septic shock; J. A. M.A., 191: 731, 1965.
  • 19 — A Multicentre Trial : Propranolol in acute myocardial ffifarction; Lancet., 2 : 1435, 1966.
  • 20 — SELZER, A. : The hypotensive state following acute myocardial infarcti on I. Clinical observations; Amer. Heart. J., 44 : I, 1952. (Özet : MARSHALL, R. J., DARBY, T. D; Shock, Pharmacological Priciples in Treatment. Edited by Kugelmass, I. N., 36, 1966).
  • 21 TÜRKÐR, K. R. : Effect of angiotensin on the cerdiac arrhytmlag induced by g strophantin; Experientia. 20 : 707, 1965 . 22 Bn,TDER, M. J., RYAN, J. A., JR., MARCUS, S., MUGLER, F., JR., STRANGE, D., AGRESS, C. M. : mraluation of therapy in shock following acute myocardial infarction; Amer. J. Med. 18 : 622, 1955. (Özet MARSHALL, R. J., DARBY, T. D. ; Shock, Pharmacological Principles in Treatment., Edited by Kugelmass, I. Ñ., 36, 1966).
  • 23 — LILLEHEt, R. C., DIETZMAN, A. H., MOVSAS, S., BLOCH, J. H. : Treatment of septic shoc; Mod. Treat., 4 : 321, 1967.
  • 24 — MC. CLELLAND, R. N., SHtRËS, T., BAXTER, C. R., COLN, C. D, CARRtCO, J. : Balanced salt solution in the treatment of hemorrhagic shock; J. A. M. A., 199 : 830, 1967.
  • 25 — VICK, J. A. : Vasodilatator therapy in acute hemorrhagic shock; Circ. Res., 16 : 58, 1965.
  • 26 — MURPHY, G. W., GLICK, G., SCHREINER, B. F., JR., YU., YU, P. N. : Cardiac output in acute myocardial infarction. Serial determination by precordial radio-isotope dilation curve; Amer. J. Cardiol., 11 : 587, 1965.
  • 27 — MC. KANZIE, G. J., TAYLOR, S. H., FLENLEŸ, D. C., MC DONALD, A. H., STAUNTON, H. P., DONALD, K. W. : Circulation and respiratory studies in myocardial infarcton and cardiogentc shock; Lancet. 2 : 825, 1964.
  • 28 — HARDAWAY, R. M., JAMES, P. M., ANDERSON, R. W., BREDENBURG C. Pa., WEST, R. L. : intensive study and treatment of shock in man; J. A. M. A., 199 : 779, 1967.
  • 29 — DARBY, T. D, WATTS, D. T. : Acidosis and blood epinephrine levels in hemorrhagic hypotension; Amer. J. Physiol., 206 : 1281, 1964.
  • 30 — GUNTON, R. W., BEAULANDS, D. S. : Anglotensin in the treatment of following myocardial infarction; Amer. J. Cardiol., 14 : 370, 1964 970 GÜRLER tr.,tçtN
  • 31 — BRADLEY, B. C., w•ntr.4 M. B. : and vasodilatator dn.lgs tn the treatment of shock; Med. Treat., 4 : 243, 1967.
  • 32 — MA'ITHES, K. : Myocardial shock;- Shock Pathogenesis and Therapy, An international symposium., Stockholm, 27 th-30 th June 1961 Sponso red Ciba. Edited by Bock, K. D., 253, 1962.
  • 33 — WILSON, R. n, JABLOSRt, D. V., TH.AL, A. P. : Usage of dibenzyline in clinical shock; Surgery., 56 : 172, 1964.
  • 34 — NASH, C. B, CARTER, JR. : Hemorrhagic myocardit.is and cardiovascular collapse induced by catecholamine infusion; Arch. int. Pharmacodyn., 166 : 172, 1967.
There are 31 citations in total.

Details

Primary Language Turkish
Subjects Cardiology, ​Internal Diseases
Journal Section Research Article
Authors

Gürler İliçin This is me

Publication Date September 30, 1968
IZ https://izlik.org/JA37JP87ZH
Published in Issue Year 1968 Volume: 21 Issue: 3

Cite

APA İliçin, G. (1968). KARDİYOJENİK ŞOK VE TEDAVİSİ. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 21(3), 957-970. https://izlik.org/JA37JP87ZH
AMA 1.İliçin G. KARDİYOJENİK ŞOK VE TEDAVİSİ. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1968;21(3):957-970. https://izlik.org/JA37JP87ZH
Chicago İliçin, Gürler. 1968. “KARDİYOJENİK ŞOK VE TEDAVİSİ”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 21 (3): 957-70. https://izlik.org/JA37JP87ZH.
EndNote İliçin G (September 1, 1968) KARDİYOJENİK ŞOK VE TEDAVİSİ. Ankara Üniversitesi Tıp Fakültesi Mecmuası 21 3 957–970.
IEEE [1]G. İliçin, “KARDİYOJENİK ŞOK VE TEDAVİSİ”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 21, no. 3, pp. 957–970, Sept. 1968, [Online]. Available: https://izlik.org/JA37JP87ZH
ISNAD İliçin, Gürler. “KARDİYOJENİK ŞOK VE TEDAVİSİ”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 21/3 (September 1, 1968): 957-970. https://izlik.org/JA37JP87ZH.
JAMA 1.İliçin G. KARDİYOJENİK ŞOK VE TEDAVİSİ. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1968;21:957–970.
MLA İliçin, Gürler. “KARDİYOJENİK ŞOK VE TEDAVİSİ”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 21, no. 3, Sept. 1968, pp. 957-70, https://izlik.org/JA37JP87ZH.
Vancouver 1.Gürler İliçin. KARDİYOJENİK ŞOK VE TEDAVİSİ. Ankara Üniversitesi Tıp Fakültesi Mecmuası [Internet]. 1968 Sep. 1;21(3):957-70. Available from: https://izlik.org/JA37JP87ZH