Three Specific Multiple Myeloma Cases

Abstract

Seven out of 21460 cases who were admitted to the 1. Medical Department of Ankara Medical School during the past twenty-one years, were diagnosed to have Multiple Myeloma. In this paper, 3 Multiple Myeloma cases which manifested particular clinical aspects and had been misdiagnosed elsewhere, are presented. One of these cases 'was found to be beta type and the other was gamma type electrophore tically. However, the third case showed no electrophoretical abnormality including immuno-electrophoresis on repeated examinations. In this case, there were only scarce atypical plâsma-cells in bone-marrow at the onset. However, after the termination of the Endoxan treatment, the amount of atypical plasma cells in marrow have definitely increased. In the case which showed garıma type abormality, an increased amount of Hemoglobin A, was discovered. This case expired because of an attack of pneumonia. At necropsy, disseminated various organ plasmo-cytomas were found.

Keywords

• Multiple Myeloma
• plasma cells
• hyperglobulinemia

Özellik Gösteren Üç Multiple Myeloma Vak'ası

Abstract

Son yirmi bir yıl içinde Ankara Tıp Fakültesi 1. Tıp Fakültesi'ne başvuran 21460 vakadan yedisine Multipl Miyelom tanısı konuldu. Bu makalede, belirli klinik özellikler gösteren ve başka yerlerde yanlış tanı konmuş 3 Multipl Miyelom vakası sunulmaktadır. Bu vakalardan birinin beta tipi, diğerinin ise gama tipi elektroforetik olarak saptandığı bildirilmiştir. Ancak üçüncü vakada, tekrarlanan incelemelerde immüno-elektroforez dahil olmak üzere elektroforetik bir anormallik saptanmamıştır. Bu vakada, başlangıçta kemik iliğinde yalnızca az miktarda atipik plazma hücresi mevcuttu. Ancak, Endoxan tedavisinin sonlandırılmasından sonra, kemik iliğindeki atipik plazma hücrelerinin miktarı belirgin olarak artmıştır. Garima tipi anormallik gösteren vakada ise Hemoglobin A miktarında artış tespit edilmiştir. Bu vaka zatürre atağı nedeniyle hayatını kaybetti. Nekropside çeşitli organlarda yaygın plazmositomlar bulundu.

Keywords

• Multiple Myeloma
• plazma hücreleri
• hiperglobulinemi

References

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