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Factors Affecting The Mechanism Of The Action Of Biogen Polypeptides On Smooth Muscle

Year 1967, Volume: 20 Issue: 2, 309 - 323, 30.06.1967

Kazım Türker

https://izlik.org/JA48KS55PL

Abstract

In this review, author has summarized the principal physiologic factors which are responsible from the smooth muscle stimulation. There is a great possibility indicating a final common pathway involving ions movement in the cell membrane for the action of all directly and indirectly acting biogenic polypeptides on the smooth muscle. Fixation of calcium ion to the cell membrane and the stimulation of electrogenic sodium - pump seem to be of primary importance.

Keywords

Biogenic polypeptides Smooth muscle Mechanism of action

Ethical Statement

-

Supporting Institution

Ankara University Faculty of Medicine Institute of Pharmacology

Project Number

-

Thanks

-

References

  • 1 — BAUER, H., GOODFORD, P. J. ve HÜTER, J.: Influence of Duration of Experiment on Rate of Uptake of Radioactive Potassium in Smooth Muscle, NATURE, 200: 104, 1963.
  • 2 — BORN, G. V. R. ve BÜLBRING, E.: The movement of Potassium between smooth Muscle and the Surrounding fluid, J. PHYSIOL. (Lond.), 131 : 690, 1956.
  • 3 — BUEDING, E. ve BÜLBRING, E.: The Inhibitory Action of Adrenaline «PHARMACOLOGY of SMOOTH MUSCLE» Proc. 2nd. Int. Pharmacol. Meeting, Edited by E. BÜLBRING 6 : 37, 1964.
  • 4 — BURNSTOCK, G. ve MERRILLEES, N. C. R.: Structural and Experimental Studies on Autonomic Nerve Endings in Smooth Muscle, PHARMACOLOGY of SMOOTH MUSCLE, 2nd Int. Pharmacological Meeting, Edited by E. BÜLBRING 6 : 1, 1964.
  • 5 — BURNSTOCK, G. ve HOLMAN, M. E.: The Transmission of Exitation from Autonomic Nerve to Smooth Muscle, J. PHYSIOL, (Lond.), 155 : 115, 1961.
  • 6 — BÜLBRING, E., GOODFORD, P. J. ve SETEKLEIV, J.: The Action of Adrenaline on the Ionic Content and on Sodium and Potassium Movements in the Smooth Muscle of the Guinea - Pig Taenia Coil, BR. J. PHARMACOL. CHEMOTHER. 28 : 296, 1966.
  • 7 — VON EULER, U. S. ve LISHAJKO, F.: Inhibitory Action of Adrenergic Blocking Agents on Catecholamine Release and Uptake in Isolated Nerve Granules, ACTA, PHYSIOL. SCAND., 68 : 257, 1966.
  • 8 — EVANS, D. H. L. ve SCHILD, H. O.: Mechanism of Contraction of Smooth Muscle by Drugs, NATURE, 180 : 341, 1957.
  • 9 — EVANS, D. H. L. ve SCHILD, H. O.: Reactions of the Isolated Amnion of the Chick Suspended in Isotonic KCI, to Acetylcholine and Electrical Stimulation, J. PHYSIOL., (Lond.), 136 : 36 P., 1957.
  • 10 — FELDBERG, W. ve LEWIS, G. P.: The Action of Peptides on the Adrenal Medulla. Release of Adrenaline by Bradykinin and Angiotensin, J. PHYSIOL. (Lond.), 171 : 98, 1964.
  • 11 — GILLESPIE, J. S. ve KIRPEKAR, S. M.: The Interaction of Infused Noradrenaline by the Cat Spleen, J. PHYSIOL. (Lond.), 176 : 205, 1965.
  • 12 — GILLESPIE, J. S.: Spontaneous Mechanical and Electrical Activity of Stretched and Unstretched Intestinal Smooth Muscle Cells and Their Response to Sympathetic Nerve Stimulation, J. PHYSIOL. (Lond.), 162 : 54, 1962.
  • 13 — HODGKIN, A. L. ve HUXLEY, A. F.: Action Potentials Recorded from Inside a Nerve Fibre., NATURE, 144 : 710, 1939.
  • 14 — HODGKIN, A. L. ve KATZ, B.: The Effect of Sodium Ions on the Electrical Activity of the Giant Axon of the Squid, J. PHYSIOL. (Lond.), 108 : 37, 1949.
  • 15 — JENKINSON, D. H. ve MORTON, I. K. M.: Effects of Noradrenaline and Isoprenaline on the permeability of Depolarized Intestinal Smooth Muscle to Inorganic Ions, NATURE, 205 : 505, 1965.
  • 16 — KHAIRALLAH, P. A. ve PAGE, I. H.: Mechanism of Action of Angiotensin and Bradykinin on Smoth Muscle in situ, AM. J. of PHYSIOL. 200 : 51, 1961.
  • 17 — KHAIRALLAH, P. A., PAGE, I. H., TÜRKER, R. K.: Potentiation of Vascular Myotropic Responses by Metanephrine and other Noncatecholamines, CIRCULATION RESEARCH, 19 : 538, 1966.
  • 18 — LEWIS, G. P. ve REIT, E.: The Action of Angiotensin and Bradykinin on the Superior Cervical Ganglion of the Cat, J. PHYSIOL. (Lond.), 179 : 538, 1965.
  • 19 — OPIT, L. J. ve CHARNOCK, J. S.: A Molecular Model for A Sodium Pump, NATURE, 208 : 471, 1965.
  • 20 — ROBERTSON, P. A.: Ca++ and Contractility of Depolarized Smooth Muscle, NATURE, 186 : 316, 1960.
  • 21 — SCHILD, H. O.: Ca++ and the Effects of Drugs on Depolarized Smooth Muscle Proc. 2nd. Int. Pharmacol. Meeting edited by E. BÜLBRING, 6 : 95, 1964.
  • 22 — SKOU, J. C.: Enzymatic Basis for Active Transport of Na+ and K+ Across Cell Membrane, PHYSIOL. REV., 45 : 596, 1965.
  • 23 — TÜRKER, R. K. ve KHAIRALLAH, P. A.: Action of Eledoisin on Isolated Vacular Strips, EXPERIENTIA, 20 : 696, 1966.
  • 24 — TÜRKER, R. K., PAGE, I. H. ve KHAIRALLAH, P. A.: Angiotensin Alteration of Sodium Fluxes in Smooth Muscle, ARCH. INT. PHARMACODYN., 165 : 394, 1967.
  • 25 — TÜRKER, R. K.: Effect of Angiotensin on the Cardiac Arrhythmias Induced by g - Strophanthin, EXPERIENTIA, 21 : 707, 1965.
  • 26 — TÜRKER, R. K., KHAIRALLAH, P. A.: Demethylimipramine (DESIFRAMINE), An Alfa - Adrenergic Blocking Agent. EXPERIENTIA 23 : 252, 1967.

Biyojen Polipeptidlerin Düz Adaleye Tesir Mekanizmasında Etkili Faktörler

Year 1967, Volume: 20 Issue: 2, 309 - 323, 30.06.1967

Kazım Türker

https://izlik.org/JA48KS55PL

Abstract

Bu yazıda, düz adalenin kasılma ve gevşemesinden sorumlu belli başlı fizyolojik üniteler hüküm edilmiştir. Büyük bir ihtimalle, düz adaleye tesir eden biyogen polipeptidler, bu tesirlerini ister direkt ister indirekt yapısınlar, hücre membranı seviyesinde ion nakliyeti üzerinden, müşterek nihayi bir yolda etkilidirler. Kalsiyum ionunun hücre membranına yapışması ve sodium pomp’unun tenbihi ilk plânda ehemmiyete haiz görülmektedir.

Keywords

Biyogen polipeptidler Düz adale Tesir mekanizması

Ethical Statement

-

Supporting Institution

Ankara Üniversitesi Tıp Fakültesi Farmakoloji Enstitüsü

Project Number

-

Thanks

-

References

  • 1 — BAUER, H., GOODFORD, P. J. ve HÜTER, J.: Influence of Duration of Experiment on Rate of Uptake of Radioactive Potassium in Smooth Muscle, NATURE, 200: 104, 1963.
  • 2 — BORN, G. V. R. ve BÜLBRING, E.: The movement of Potassium between smooth Muscle and the Surrounding fluid, J. PHYSIOL. (Lond.), 131 : 690, 1956.
  • 3 — BUEDING, E. ve BÜLBRING, E.: The Inhibitory Action of Adrenaline «PHARMACOLOGY of SMOOTH MUSCLE» Proc. 2nd. Int. Pharmacol. Meeting, Edited by E. BÜLBRING 6 : 37, 1964.
  • 4 — BURNSTOCK, G. ve MERRILLEES, N. C. R.: Structural and Experimental Studies on Autonomic Nerve Endings in Smooth Muscle, PHARMACOLOGY of SMOOTH MUSCLE, 2nd Int. Pharmacological Meeting, Edited by E. BÜLBRING 6 : 1, 1964.
  • 5 — BURNSTOCK, G. ve HOLMAN, M. E.: The Transmission of Exitation from Autonomic Nerve to Smooth Muscle, J. PHYSIOL, (Lond.), 155 : 115, 1961.
  • 6 — BÜLBRING, E., GOODFORD, P. J. ve SETEKLEIV, J.: The Action of Adrenaline on the Ionic Content and on Sodium and Potassium Movements in the Smooth Muscle of the Guinea - Pig Taenia Coil, BR. J. PHARMACOL. CHEMOTHER. 28 : 296, 1966.
  • 7 — VON EULER, U. S. ve LISHAJKO, F.: Inhibitory Action of Adrenergic Blocking Agents on Catecholamine Release and Uptake in Isolated Nerve Granules, ACTA, PHYSIOL. SCAND., 68 : 257, 1966.
  • 8 — EVANS, D. H. L. ve SCHILD, H. O.: Mechanism of Contraction of Smooth Muscle by Drugs, NATURE, 180 : 341, 1957.
  • 9 — EVANS, D. H. L. ve SCHILD, H. O.: Reactions of the Isolated Amnion of the Chick Suspended in Isotonic KCI, to Acetylcholine and Electrical Stimulation, J. PHYSIOL., (Lond.), 136 : 36 P., 1957.
  • 10 — FELDBERG, W. ve LEWIS, G. P.: The Action of Peptides on the Adrenal Medulla. Release of Adrenaline by Bradykinin and Angiotensin, J. PHYSIOL. (Lond.), 171 : 98, 1964.
  • 11 — GILLESPIE, J. S. ve KIRPEKAR, S. M.: The Interaction of Infused Noradrenaline by the Cat Spleen, J. PHYSIOL. (Lond.), 176 : 205, 1965.
  • 12 — GILLESPIE, J. S.: Spontaneous Mechanical and Electrical Activity of Stretched and Unstretched Intestinal Smooth Muscle Cells and Their Response to Sympathetic Nerve Stimulation, J. PHYSIOL. (Lond.), 162 : 54, 1962.
  • 13 — HODGKIN, A. L. ve HUXLEY, A. F.: Action Potentials Recorded from Inside a Nerve Fibre., NATURE, 144 : 710, 1939.
  • 14 — HODGKIN, A. L. ve KATZ, B.: The Effect of Sodium Ions on the Electrical Activity of the Giant Axon of the Squid, J. PHYSIOL. (Lond.), 108 : 37, 1949.
  • 15 — JENKINSON, D. H. ve MORTON, I. K. M.: Effects of Noradrenaline and Isoprenaline on the permeability of Depolarized Intestinal Smooth Muscle to Inorganic Ions, NATURE, 205 : 505, 1965.
  • 16 — KHAIRALLAH, P. A. ve PAGE, I. H.: Mechanism of Action of Angiotensin and Bradykinin on Smoth Muscle in situ, AM. J. of PHYSIOL. 200 : 51, 1961.
  • 17 — KHAIRALLAH, P. A., PAGE, I. H., TÜRKER, R. K.: Potentiation of Vascular Myotropic Responses by Metanephrine and other Noncatecholamines, CIRCULATION RESEARCH, 19 : 538, 1966.
  • 18 — LEWIS, G. P. ve REIT, E.: The Action of Angiotensin and Bradykinin on the Superior Cervical Ganglion of the Cat, J. PHYSIOL. (Lond.), 179 : 538, 1965.
  • 19 — OPIT, L. J. ve CHARNOCK, J. S.: A Molecular Model for A Sodium Pump, NATURE, 208 : 471, 1965.
  • 20 — ROBERTSON, P. A.: Ca++ and Contractility of Depolarized Smooth Muscle, NATURE, 186 : 316, 1960.
  • 21 — SCHILD, H. O.: Ca++ and the Effects of Drugs on Depolarized Smooth Muscle Proc. 2nd. Int. Pharmacol. Meeting edited by E. BÜLBRING, 6 : 95, 1964.
  • 22 — SKOU, J. C.: Enzymatic Basis for Active Transport of Na+ and K+ Across Cell Membrane, PHYSIOL. REV., 45 : 596, 1965.
  • 23 — TÜRKER, R. K. ve KHAIRALLAH, P. A.: Action of Eledoisin on Isolated Vacular Strips, EXPERIENTIA, 20 : 696, 1966.
  • 24 — TÜRKER, R. K., PAGE, I. H. ve KHAIRALLAH, P. A.: Angiotensin Alteration of Sodium Fluxes in Smooth Muscle, ARCH. INT. PHARMACODYN., 165 : 394, 1967.
  • 25 — TÜRKER, R. K.: Effect of Angiotensin on the Cardiac Arrhythmias Induced by g - Strophanthin, EXPERIENTIA, 21 : 707, 1965.
  • 26 — TÜRKER, R. K., KHAIRALLAH, P. A.: Demethylimipramine (DESIFRAMINE), An Alfa - Adrenergic Blocking Agent. EXPERIENTIA 23 : 252, 1967.
There are 26 citations in total.

Details

Primary Language Turkish
Subjects Basic Pharmacology
Journal Section Review
Authors

Kazım Türker This is me

Project Number -
Publication Date June 30, 1967
IZ https://izlik.org/JA48KS55PL
Published in Issue Year 1967 Volume: 20 Issue: 2

Cite

APA Türker, K. (1967). Biyojen Polipeptidlerin Düz Adaleye Tesir Mekanizmasında Etkili Faktörler. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 20(2), 309-323. https://izlik.org/JA48KS55PL
AMA 1.Türker K. Biyojen Polipeptidlerin Düz Adaleye Tesir Mekanizmasında Etkili Faktörler. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1967;20(2):309-323. https://izlik.org/JA48KS55PL
Chicago Türker, Kazım. 1967. “Biyojen Polipeptidlerin Düz Adaleye Tesir Mekanizmasında Etkili Faktörler”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 20 (2): 309-23. https://izlik.org/JA48KS55PL.
EndNote Türker K (June 1, 1967) Biyojen Polipeptidlerin Düz Adaleye Tesir Mekanizmasında Etkili Faktörler. Ankara Üniversitesi Tıp Fakültesi Mecmuası 20 2 309–323.
IEEE [1]K. Türker, “Biyojen Polipeptidlerin Düz Adaleye Tesir Mekanizmasında Etkili Faktörler”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 20, no. 2, pp. 309–323, June 1967, [Online]. Available: https://izlik.org/JA48KS55PL
ISNAD Türker, Kazım. “Biyojen Polipeptidlerin Düz Adaleye Tesir Mekanizmasında Etkili Faktörler”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 20/2 (June 1, 1967): 309-323. https://izlik.org/JA48KS55PL.
JAMA 1.Türker K. Biyojen Polipeptidlerin Düz Adaleye Tesir Mekanizmasında Etkili Faktörler. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1967;20:309–323.
MLA Türker, Kazım. “Biyojen Polipeptidlerin Düz Adaleye Tesir Mekanizmasında Etkili Faktörler”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 20, no. 2, June 1967, pp. 309-23, https://izlik.org/JA48KS55PL.
Vancouver 1.Kazım Türker. Biyojen Polipeptidlerin Düz Adaleye Tesir Mekanizmasında Etkili Faktörler. Ankara Üniversitesi Tıp Fakültesi Mecmuası [Internet]. 1967 Jun. 1;20(2):309-23. Available from: https://izlik.org/JA48KS55PL