Abstract
White male mice, Ankara type, nearly three-month old, were injected subcutaneously with 1 mg of prednisolone sodium succinate daily for a period of 94 days. Examination of liver, lungs, spleen, pancreas, kidneys, adrenal glands, and testes revealed weight loss, mild hepatic fatty degeneration, advanced bronchitis, inflammatory infiltration in pancreas, tubular degeneration and interstitial inflammation in kidneys, and widespread vascular changes. Cortisone was found to facilitate infection in multiple organs. Interestingly, the 94-day treatment did not produce changes as dramatic as those seen in shorter-duration studies.
Keywords
Cortisone albino mice liver degeneration bronchitis adrenal atrophy inflammatory infiltration
References
- 1 - Perez-Tamayo, R.; Murphy, W. R.; Ihnen, M.: Exc. Med. 7 Sec. V, 125, 1954.
- 2 - Rovillard, J. M.; Henry, R.: Exc. Med. 7 Sec. V, 413. 1954.
- 3 - Schmid-Bircher, M.: Histological organic changes in rabbits following high doses of cortisone. Beitr. Path. Anat. 114: 136, 1954.
- 4 - Herlant, M.; Toussaint, Cu.: Exc. Med. 5 Sec. V. 719, 1952.
- 5 - Ermaumoon, E. M.; Hochligeti, C.: Lipid deposition in aortas in younger age groups following cortisone and adrenocorticotrophic hormone. Amer. J. Path. 28: 315, 1952.
- 6 - Betz, H.; Van Cauwenberge, H.; Vliers M.: Exc. Med. 12 Sec. V. 902, 1959.
- 7 - Igaku Kenkyu: Exc. Med. 12 Sec. V. 115, 1959.
- 8 - Amira, A.; Borasi, M.; Cavallero, C.; Sala, G.: Exc. Med. 5 Sec. V. 139, 1952.
- 9 - Eteve, J.; Zervoyannis, S.: Action of cortisone on the structures of the liver cells. La Pres. Med. 60: 248, 1952.
- 10 - Winblad, S.; Johnson, S.: Exc. Med. 7 Sec. V, 727, 1954.
- 11 - Baxter, T. J.: Exc. Med. 13 Sec. V. 726, 1960.
- 12 - Lanza, B.; Frasineti, A.: Exc. Med. 6 Sec. V. 114, 1953.
- 13 - Tuchmann-Duplessis, H.: Exc. Med. 5 Sec. V, 499, 1952.
Abstract
Takriben 3 aylık Ankara tipi beyaz erkek farelere 94 gün boyunca her gün 1 mg prednizolon sodyum suksinat verildi. Karaciğer, akciğer, dalak, pankreas, böbrek, sürrenal ve testislerde yapılan tetkiklerde; ağırlık kaybı, bazı vakalarda küçük yağlanma odakları, ileri evrelerde kolanjiolit ve toksik hepatit, akciğerlerde bronşit, pankreasta iltihabi infiltrasyon, böbreklerde tübüler dejenerasyon ve iltihabi odaklar ile damarlarda endotel proliferasyonu ve cidar kalınlaşması gözlendi. Kortizonun infeksiyonları kolaylaştırıcı etkisi vurgulandı. Ancak 94 günlük tatbikatta, literatürde kısa sürede bildirilen kadar çarpıcı lezyonlara rastlanmadı.
References
- 1 - Perez-Tamayo, R.; Murphy, W. R.; Ihnen, M.: Exc. Med. 7 Sec. V, 125, 1954.
- 2 - Rovillard, J. M.; Henry, R.: Exc. Med. 7 Sec. V, 413. 1954.
- 3 - Schmid-Bircher, M.: Histological organic changes in rabbits following high doses of cortisone. Beitr. Path. Anat. 114: 136, 1954.
- 4 - Herlant, M.; Toussaint, Cu.: Exc. Med. 5 Sec. V. 719, 1952.
- 5 - Ermaumoon, E. M.; Hochligeti, C.: Lipid deposition in aortas in younger age groups following cortisone and adrenocorticotrophic hormone. Amer. J. Path. 28: 315, 1952.
- 6 - Betz, H.; Van Cauwenberge, H.; Vliers M.: Exc. Med. 12 Sec. V. 902, 1959.
- 7 - Igaku Kenkyu: Exc. Med. 12 Sec. V. 115, 1959.
- 8 - Amira, A.; Borasi, M.; Cavallero, C.; Sala, G.: Exc. Med. 5 Sec. V. 139, 1952.
- 9 - Eteve, J.; Zervoyannis, S.: Action of cortisone on the structures of the liver cells. La Pres. Med. 60: 248, 1952.
- 10 - Winblad, S.; Johnson, S.: Exc. Med. 7 Sec. V, 727, 1954.
- 11 - Baxter, T. J.: Exc. Med. 13 Sec. V. 726, 1960.
- 12 - Lanza, B.; Frasineti, A.: Exc. Med. 6 Sec. V. 114, 1953.
- 13 - Tuchmann-Duplessis, H.: Exc. Med. 5 Sec. V, 499, 1952.
Details
| Primary Language | English |
|---|---|
| Subjects | Pathology |
| Journal Section | Research Article |
| Authors | |
| Publication Date | September 30, 1963 |
| IZ | https://izlik.org/JA95WY82BJ |
| Published in Issue | Year 1963 Volume: 16 Issue: 3 |