Özofagus Varisi Kanamaları ve Portal Basınç Üzerine Hipofiz Arka Lobu Ekstrelerinin (Postuitrin) Tesiri
Abstract
The Effect of Pituitrin Upon Portal Pressure and Hemorrhage of Esophageal Varices This clinical study examines the use of pituitrin, a posterior pituitary extract, in managing bleeding from esophageal varices by its potential to reduce portal hypertension. Five patients with various conditions underwent intravenous administration of 20 units of pituitrin, and portal pressure was measured via intraoperative catheterization. In two cases, portal pressure decreased significantly; in one case it remained unchanged; and in two cases it increased slightly. Parallel use of ephedrine resulted in both systemic and portal pressure elevation. The variability in response is attributed to biological activity differences and potential histamine content in pituitary extracts derived from animals. Despite risks of hypotension, pituitrin shows promise in emergency control of variceal bleeding and may act synergistically with Sengstaken-Blakemore tube application.
Keywords
References
- 1 - Ayral, N.: Portal hipertansiyon yapmış bir vena lienalis trombozu vak'ası. Ankara Tıp Fak. Mec. XV, II, 1962.
- 2 - Ayral, N.: Shunt ameliyatlarından aldığımız neticeler. Amonyakemi meselesi. Ankara Tıp Fak. Mec. XII, sayı 34, 1959.
- 3 - Davis: Surgical Physiology. Hoeber, Harper, 1957.
- 4 - Edmunds, R.: Effect of Vasopressin on Portal and Systemic Pressure. Surg. Gyn. Obst., 114:458, 1962.
- 5 - Harris, P.D.: Hepatic oxygen tension after Pitressin. Surg., 49:514, 1961.
- 6 - Heimburger, I.: Pituitrin on portal and hepatic circulation. Surgery, 48:706, 1960.
- 7 - Herman, G.: Portocaval shunt evaluation. Surgery Gyn. Obst., 116:285, 1963.
- 8 - Krhne, J.H.; Hughes, F.A.: Pituitrin in esophageal varix bleeding. Surgery, 39:917, 1956.
- 9 - Schwartz, S.I. et al.: Intravenous Pituitrin in bleeding varices. Surgery, 45:72, 1959.
Özofagus Varisi Kanamaları ve Portal Basınç Üzerine Hipofiz Arka Lobu Ekstrelerinin (Postuitrin) Tesiri
Abstract
The Effect of Pituitrin Upon Portal Pressure and Hemorrhage of Esophageal Varices This clinical study examines the use of pituitrin, a posterior pituitary extract, in managing bleeding from esophageal varices by its potential to reduce portal hypertension. Five patients with various conditions underwent intravenous administration of 20 units of pituitrin, and portal pressure was measured via intraoperative catheterization. In two cases, portal pressure decreased significantly; in one case it remained unchanged; and in two cases it increased slightly. Parallel use of ephedrine resulted in both systemic and portal pressure elevation. The variability in response is attributed to biological activity differences and potential histamine content in pituitary extracts derived from animals. Despite risks of hypotension, pituitrin shows promise in emergency control of variceal bleeding and may act synergistically with Sengstaken-Blakemore tube application.
References
- 1 - Ayral, N.: Portal hipertansiyon yapmış bir vena lienalis trombozu vak'ası. Ankara Tıp Fak. Mec. XV, II, 1962.
- 2 - Ayral, N.: Shunt ameliyatlarından aldığımız neticeler. Amonyakemi meselesi. Ankara Tıp Fak. Mec. XII, sayı 34, 1959.
- 3 - Davis: Surgical Physiology. Hoeber, Harper, 1957.
- 4 - Edmunds, R.: Effect of Vasopressin on Portal and Systemic Pressure. Surg. Gyn. Obst., 114:458, 1962.
- 5 - Harris, P.D.: Hepatic oxygen tension after Pitressin. Surg., 49:514, 1961.
- 6 - Heimburger, I.: Pituitrin on portal and hepatic circulation. Surgery, 48:706, 1960.
- 7 - Herman, G.: Portocaval shunt evaluation. Surgery Gyn. Obst., 116:285, 1963.
- 8 - Krhne, J.H.; Hughes, F.A.: Pituitrin in esophageal varix bleeding. Surgery, 39:917, 1956.
- 9 - Schwartz, S.I. et al.: Intravenous Pituitrin in bleeding varices. Surgery, 45:72, 1959.
Details
| Primary Language | English |
|---|---|
| Subjects | General Surgery |
| Journal Section | Research Article |
| Authors | |
| Publication Date | September 30, 1963 |
| IZ | https://izlik.org/JA77LY22ML |
| Published in Issue | Year 1963 Volume: 16 Issue: 3 |