Cushing's Disease and Cushing's Syndrome: A Report of Two Cases

Year 1958, Volume: 11 Issue: 3-4, 139 - 146, 30.12.1958

İhsan Günalp

Abstract

This study reviews the clinical features of Cushing's disease and Cushing's syndrome and presents two cases treated at the Urology Clinic of Ankara Medical Faculty. The first case involved a 19-year-old male patient treated with bilateral adrenalectomy and pituitary irradiation. The second case was a 20-year-old female patient who underwent surgical intervention for an adrenal adenoma but was lost due to postoperative complications.

Characteristic findings in both cases included moon face, hypertension, hirsutism, osteoporosis, and striae on the skin. Laboratory results revealed elevated 17-ketosteroid levels, hyperglycemia, and eosinopenia. Treatment approaches included surgical intervention, pituitary irradiation, and corticosteroid replacement. The study highlights the importance of a multidisciplinary approach in the diagnosis and management of these rare endocrinopathies.

Keywords

cushing , hastalık , sendrom

Cushing Hastalığı ve Cushing Sendromu: İki Vaka Sunumu

Abstract

Bu çalışmada, Cushing hastalığı ve Cushing sendromunun klinik özellikleri gözden geçirilmiş ve Ankara Tıp Fakültesi Üroloji Kliniği'nde tedavi edilen iki vaka sunulmuştur. İlk vaka, 19 yaşında bir erkek hasta olup bilateral sürrenalektomi ve hipofiz ışınlaması ile tedavi edilmiştir. İkinci vaka ise 20 yaşında bir kadın hasta olup sürrenal adenomu nedeniyle cerrahi müdahale görmüş, ancak postoperatif komplikasyonlar nedeniyle kaybedilmiştir.

Her iki vakada da karakteristik bulgular arasında yuvarlak yüz (ay dede yüzü), hipertansiyon, hirsutizm, osteoporoz ve ciltte striae yer almaktadır. Laboratuvar bulgularında ise artmış 17-ketosteroid düzeyleri, hiperglisemi ve eozinopeni dikkat çekmiştir. Tedavi yaklaşımları arasında cerrahi müdahale, hipofiz ışınlaması ve kortikosteroid replasmanı yer almıştır. Çalışma, bu nadir endokrinopatilerin tanı ve tedavisinde multidisipliner bir yaklaşımın önemini vurgulamaktadır

Keywords

cushing , hastalık , sendrom

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