Review

Oral Antidiyabetiklerle 4 Senelik Tecrübe

Volume: 14 Number: 1 February 28, 1961
Cavit Sökmen
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Oral Antidiyabetiklerle 4 Senelik Tecrübe

Abstract

Oral antidiabetic agents spare patients from daily injections, yet they still fall short of meeting all therapeutic needs. Over a 4-year period, we treated 70 diabetic cases with various oral antidiabetics. Carbutamide was discontinued due to its toxicity. Tolbutamide showed minimal side effects and a 66% success rate. Chlorpropamide, though potent, required careful monitoring due to adverse reactions and achieved a 60% success rate. Biguanide derivative DBI showed mild hypoglycemic effect with promising results in adult-type diabetes but failed to stabilize juvenile-type diabetes. Despite limitations, tolbutamide appears to hold a favorable position among current agents.

Keywords

oral antidiabetics, sulfonylureas, tolbutamide, chlorpropamide, biguanides

References

  1. Bertram, T. Experiences recueillies sur 1000 diabetiques traites par les sulfonylurees (BZ 55 et D 860). La Gaz. Med. de France 1957, 6, 519.
  2. Hedon, L., Loubatieres, A. Les sulfamides hypoglycemiants et leur interet pour le traitement du diabete. Ann. d'Endocr. 1957, 18-4, 477.
  3. Hoet, J. P. Conclusions a propos de l'emploi des sulfamides hypoglycemiants en clinique humaine. Ann. d'Endocr. 1957, 18-2, 396.
  4. Hunt, J. A., Oakley, W. Clinical trial of the new oral hypoglycaemic agent BZ 55. Br. Med. Jour. 1956, 4960, 445.
  5. Jersild, M. Quelques experiences cliniques sur des substances hypoglycemiantes orales. Ann. d'Endocr. 1957, 18-2, 271.
  6. Kaldor, A., Pogatsa, G. The mode of action of oral antidiabetic compounds. Lancet 1959, 7069, 386.
  7. Krall, L. P. Clinical use of Biguanide and their role in stabilizing juvenile-type diabetes. Diabetes 1958, 7, 468.
  8. Loubatieres, A. La contribution française a la decouverte des proprietes hypoglycemiantes et antidiabetiques de certains sulfamides. La Gaz. Med. de France 1957, 6, 505.
  9. Loubatieres, A. Le mecanisme d'action des sulfamides hypoglycemiants et de leurs derives. Ann. d'Endocr. 1957, 18-2, 161.
  10. Loubatieres, A. Action des sulfamides hypoglycemiants et de leurs derives chez l'homme diabetique. Ann. d'Endocr. 1957, 18-2, 260.

Details

Primary Language

English

Subjects

​Internal Diseases

Journal Section

Review

Authors

Cavit Sökmen This is me
Türkiye

Publication Date

February 28, 1961

Submission Date

January 1, 1961

Acceptance Date

February 28, 1961

Published in Issue

Year 1961 Volume: 14 Number: 1

IZ

https://izlik.org/JA59JP32NK

Cite

RIS / Bibtex
APA
Sökmen, C. (1961). Oral Antidiyabetiklerle 4 Senelik Tecrübe. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 14(1), 45-49. https://izlik.org/JA59JP32NK
AMA
1.Sökmen C. Oral Antidiyabetiklerle 4 Senelik Tecrübe. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1961;14(1):45-49. https://izlik.org/JA59JP32NK
Chicago
Sökmen, Cavit. 1961. “Oral Antidiyabetiklerle 4 Senelik Tecrübe”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 14 (1): 45-49. https://izlik.org/JA59JP32NK.
EndNote
Sökmen C (February 1, 1961) Oral Antidiyabetiklerle 4 Senelik Tecrübe. Ankara Üniversitesi Tıp Fakültesi Mecmuası 14 1 45–49.
IEEE
[1]C. Sökmen, “Oral Antidiyabetiklerle 4 Senelik Tecrübe”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 14, no. 1, pp. 45–49, Feb. 1961, [Online]. Available: https://izlik.org/JA59JP32NK
ISNAD
Sökmen, Cavit. “Oral Antidiyabetiklerle 4 Senelik Tecrübe”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 14/1 (February 1, 1961): 45-49. https://izlik.org/JA59JP32NK.
JAMA
1.Sökmen C. Oral Antidiyabetiklerle 4 Senelik Tecrübe. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1961;14:45–49.
MLA
Sökmen, Cavit. “Oral Antidiyabetiklerle 4 Senelik Tecrübe”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 14, no. 1, Feb. 1961, pp. 45-49, https://izlik.org/JA59JP32NK.
Vancouver
1.Cavit Sökmen. Oral Antidiyabetiklerle 4 Senelik Tecrübe. Ankara Üniversitesi Tıp Fakültesi Mecmuası [Internet]. 1961 Feb. 1;14(1):45-9. Available from: https://izlik.org/JA59JP32NK