Triparanol’un Kolesterolemi, Lipidemi ve Kanın Lipoprotein Fraksiyonları Üzerine Tesirleri
Abstract
The effects of Triparanol on cholesterolemia, lipidemia, and blood lipoprotein fractions were investigated in 26 cases. Cholesterolemia decreased in 16 cases, remained unchanged in 6, and increased in 4. Total lipidemia decreased in 11 cases, remained unchanged in 4, and increased in 1. Lipoprotein fractions showed favorable changes in 60% of cases and unfavorable in 40%. The authors note that Triparanol was withdrawn from the market in the United States due to side effects such as cataracts, alopecia, urticaria, and vaginal bleeding. They recommend cautious use only in cases where unsaturated fatty acids fail to reduce cholesterol levels.
Keywords
Triparanol, Cholesterolemia, Lipidemia, Lipoprotein fractions
Triparanol’un Kolesterolemi, Lipidemi ve Kanın Lipoprotein Fraksiyonları Üzerine Tesirleri
Abstract
The effects of Triparanol on cholesterolemia, lipidemia, and blood lipoprotein fractions were investigated in 26 cases. Cholesterolemia decreased in 16 cases, remained unchanged in 6, and increased in 4. Total lipidemia decreased in 11 cases, remained unchanged in 4, and increased in 1. Lipoprotein fractions showed favorable changes in 60% of cases and unfavorable in 40%. The authors note that Triparanol was withdrawn from the market in the United States due to side effects such as cataracts, alopecia, urticaria, and vaginal bleeding. They recommend cautious use only in cases where unsaturated fatty acids fail to reduce cholesterol levels.