Case Report
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Karşı Meme İnvaziv Lobüler Karsinomu: Önceki İnvaziv Duktal Karsinom Öyküsü Olan Bir Hastada MRG ile Saptanan ve Elastografi ile Ayırt Edilen İntramamarian Lenf Nodu Benzeri Lezyon

Year 2026, Volume: 79 Issue: 1, 1 - 7, 27.03.2026
https://doi.org/10.65092/autfm.1802744
https://izlik.org/JA83JP65WW

Abstract

Bu olgu sunumunda, invaziv duktal karsinom (IDC) tedavisinden üç yıl sonra karşı memede invaziv lobüler karsinom (ILC) tanısı alan nadir bir olgu sunulmaktadır. Tarama amaçlı yapılan meme manyetik rezonans görüntülemesinde (MRG) tesadüfen saptanan yeni lezyon, iyi sınırlı görünümü ve hilus benzeri ekojenitesi nedeniyle MRG ve ultrasonografide intramamari lenf nodunu taklit etmiştir. Shear-wave elastografi incelemesinde yüksek sertlik değerleri saptanmış ve malignite şüphesi doğmuştur. Kor biyopsi sonucunda invaziv lobüler karsinom tanısı doğrulanmıştır. Bu olgu, klinik olarak belirti vermeyen kanserlerin saptanmasında MRG’nin önemini ve benign yapıları taklit eden malign lezyonların ayırıcı tanısında elastografinin potansiyel rolünü vurgulamaktadır.

Ethical Statement

Bu olgu sunumu, Ankara Güven Hastanesi Bilimsel Kurulu tarafından onaylanmıştır (Onay tarihi: 4 Eylül 2025). Çalışma, Helsinki Bildirgesi ilkelerine uygun olarak yürütülmüştür. Bu olgu ve eşlik eden görüntülerin yayımlanması için hastadan yazılı bilgilendirilmiş onam alınmıştır.

Supporting Institution

Bu çalışma, Ankara Güven Hastanesi Radyoloji Bölümü tarafından desteklenmiştir.

Thanks

Yazarlar, bu çalışmanın gerçekleşmesine olanak sağlayan sürekli destekleri, özverileri ve klinik ile araştırma çalışmalarındaki iş birlikleri için Ankara Güven Hastanesi Meme Merkezi’nin tüm üyelerine içten teşekkürlerini sunar.

References

  • Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–249.
  • van der Waal D, Verbeek ALM, den Heeten GJ, Ripping TM, Tjan-Heijnen VCG, Broeders MJM. Breast cancer diagnosis and death in the Netherlands: a changing burden. Eur J Public Health. 2015;25:320–324.
  • Sun YS, Zhao Z, Yang ZN, Xu F, Lu HJ, Zhu ZY, et al. Risk factors and preventions of breast cancer. Int J Biol Sci. 2017;13:1387–1397.
  • Nolan E, Lindeman GJ, Visvader JE. Deciphering breast cancer: from biology to the clinic. Cell. 2023;186:1708–1728.
  • Weigelt B, Reis-Filho JS. Histological and molecular types of breast cancer: is there a unifying taxonomy? Nat Rev Clin Oncol. 2009;6:718–730.
  • Hashim D, Boffetta P, La Vecchia C, Rota M, Bertuccio P, Malvezzi M, et al. The global decrease in cancer mortality: trends and disparities. Ann Oncol. 2016;27:926–933.
  • van Winkel SL, Sechopoulos I, Rodríguez-Ruiz A, Veldkamp WJH, Gennaro G, Chevalier M, et al. An exploration of discrepant recalls between AI and human readers of malignant lesions in digital mammography screening. Diagnostics (Basel). 2025;15:1566.
  • Saslow D, Boetes C, Burke W, Harms S, Leach MO, Lehman CD, et al. American Cancer Society guidelines for breast screening with MRI as an adjunct to mammography. CA Cancer J Clin. 2007;57:75–89.
  • Vegunta S, Bhatt AA, Choudhery SA, Pruthi S, Kaur AS. Identifying women with increased risk of breast cancer and implementing risk-reducing strategies and supplemental imaging. Breast Cancer. 2022;29:19–29.
  • Sardanelli F, Podo F, Santoro F, Manoukian S, Bergonzi S, Trecate G, et al. Multicenter surveillance of women at high genetic breast cancer risk using mammography, ultrasonography, and contrast-enhanced magnetic resonance imaging. Invest Radiol. 2011;46:94–105.
  • Vreemann S, Rodriguez-Ruiz A, Nickel D, Heacock L, Appelman L, van Zelst J, et al. Compressed sensing for breast MRI: resolving the trade-off between spatial and temporal resolution. Invest Radiol. 2017;52:574–582.
  • Hernández ML, Osorio S, Florez K, Ospino A, Díaz GM. Abbreviated magnetic resonance imaging in breast cancer: a systematic review. Eur J Radiol Open. 2021;8:100307.
  • Warner E, Messersmith H, Causer P, Eisen A, Shumak R, Plewes D. Using magnetic resonance imaging to screen women at high risk for breast cancer: a systematic review. Ann Intern Med. 2008;148:671–679.
  • Evans DGR, Harkness EF, Howell A, Wilson M, Hurley E, Holmen MM, et al. Intensive breast screening in BRCA2 mutation carriers is associated with reduced breast cancer–specific and all-cause mortality. Hered Cancer Clin Pract. 2016;14:8.
  • Mann RM, Cho N, Moy L. Breast MRI: state of the art. Radiology. 2019;292:520–536.
  • Mann RM, Balleyguier C, Baltzer PA, Bick U, Colin C, Cornford E, et al. Breast MRI: EUSOBI recommendations for women’s information. Eur Radiol. 2015;25:3669–3678.
  • Monticciolo DL, Newell MS, Moy L, Niell B, Monsees B, Sickles EA. Breast cancer screening in women at higher-than-average risk: recommendations from the ACR. J Am Coll Radiol. 2018;15:408–414.
  • Gilbert FJ, Payne NR, Allajbeu I, Yit L, Vinnicombe S, Lyburn I, et al. Comparison of supplemental breast cancer imaging techniques: interim results from the BRAID randomized controlled trial. Lancet. 2025;405:1935–1944.
  • Youk JH, Gweon HM, Son EJ. Shear-wave elastography in breast ultrasonography: the state of the art. Ultrasonography. 2017;36:300–309.
  • Menzilcioğlu MS, Çitil S. Strain wave elastography imaging for the evaluation of pancreas in healthy volunteers. Eur J Ther. 2023;26:229–232.
  • Chamming’s F, Hangard C, Gennisson JL, Reinhold C, Fournier LS. Diagnostic accuracy of four levels of manual compression applied in supersonic shear wave elastography of the breast. Acad Radiol. 2021;28:481–486.
  • Wang ZL, Sun L, Li Y, Li N. Relationship between elasticity and collagen fiber content in breast disease: a preliminary report. Ultrasonics. 2015;57:44–49.
  • Mahmoud ZMS, El-Shinnawy MAM, Ali NSAA. Diagnostic role of shear wave elastography in differentiating benign from malignant breast masses. Egypt J Radiol Nucl Med. 2025;56:130.
  • Shahzad R, Fatima I, Anjum T, Shahid A. Diagnostic value of strain elastography and shear wave elastography in differentiating benign and malignant breast lesions. Ann Saudi Med. 2022;42:319–326.
  • Kim H, Lee J, Kang BJ, Kim SH. What shear wave elastography parameter best differentiates breast cancer and predicts its histologic aggressiveness? Ultrasonography. 2021;40:265–273.
  • Jia W, Luo T, Dong Y, Zhang X, Zhan W, Zhou J. Breast elasticity imaging techniques: comparison of strain elastography and shear-wave elastography. Ultrasound Med Biol. 2021;47:104–113.
  • Hong MJ, Cha JH, Kim HH, Shin HJ, Chae EY, Shin JE, et al. Second-look ultrasonography for MRI-detected suspicious breast lesions in patients with breast cancer. Ultrasonography. 2015;34:125–132.
  • Sauer ST, Geerling J, Christner SA, Schlaiß T, Kiesel M, Scherer-Quenzer AC, et al. The value of second-look ultrasound and mammography for assessment and biopsy of MRI-detected breast lesions. Acad Radiol. 2025;32:1818–1826.

Contralateral Invasive Lobular Carcinoma Mimicking an Intramammary Lymph Node: A Case Report of MRI Detection and Elastography Differentiation in a Patient with Prior IDC

Year 2026, Volume: 79 Issue: 1, 1 - 7, 27.03.2026
https://doi.org/10.65092/autfm.1802744
https://izlik.org/JA83JP65WW

Abstract

We report a rare case of contralateral invasive lobular carcinoma (ILC) diagnosed three years after initial treatment for invasive ductal carcinoma (IDC). The new lesion, detected incidentally on screening MRI, mimicked an intramammary lymph node on MRI and ultrasound due to its well-circumscribed appearance and hilar-like echogenicity. Shear-wave elastography revealed high stiffness values, raising suspicion for malignancy. Core biopsy confirmed ILC. This case underscores the critical role of MRI in detecting clinically occult cancers and highlights elastography’s potential to unmask malignancies mimicking benign structures.

Ethical Statement

This case report was approved by the Scientific Committee of Ankara Güven Hospital (Approval Date: 04 September 2025). The study was conducted in accordance with the Declaration of Helsinki. Written informed consent was obtained from the patient for publication of this case and accompanying images.

Supporting Institution

This work was supported by the Department of Radiology, Ankara Güven Hospital, Ankara, Türkiye.

Thanks

The authors would like to express their sincere gratitude to all members of the Breast Center at Ankara Güven Hospital for their continuous support, dedication, and collaboration in clinical and research activities that made this work possible.

References

  • Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–249.
  • van der Waal D, Verbeek ALM, den Heeten GJ, Ripping TM, Tjan-Heijnen VCG, Broeders MJM. Breast cancer diagnosis and death in the Netherlands: a changing burden. Eur J Public Health. 2015;25:320–324.
  • Sun YS, Zhao Z, Yang ZN, Xu F, Lu HJ, Zhu ZY, et al. Risk factors and preventions of breast cancer. Int J Biol Sci. 2017;13:1387–1397.
  • Nolan E, Lindeman GJ, Visvader JE. Deciphering breast cancer: from biology to the clinic. Cell. 2023;186:1708–1728.
  • Weigelt B, Reis-Filho JS. Histological and molecular types of breast cancer: is there a unifying taxonomy? Nat Rev Clin Oncol. 2009;6:718–730.
  • Hashim D, Boffetta P, La Vecchia C, Rota M, Bertuccio P, Malvezzi M, et al. The global decrease in cancer mortality: trends and disparities. Ann Oncol. 2016;27:926–933.
  • van Winkel SL, Sechopoulos I, Rodríguez-Ruiz A, Veldkamp WJH, Gennaro G, Chevalier M, et al. An exploration of discrepant recalls between AI and human readers of malignant lesions in digital mammography screening. Diagnostics (Basel). 2025;15:1566.
  • Saslow D, Boetes C, Burke W, Harms S, Leach MO, Lehman CD, et al. American Cancer Society guidelines for breast screening with MRI as an adjunct to mammography. CA Cancer J Clin. 2007;57:75–89.
  • Vegunta S, Bhatt AA, Choudhery SA, Pruthi S, Kaur AS. Identifying women with increased risk of breast cancer and implementing risk-reducing strategies and supplemental imaging. Breast Cancer. 2022;29:19–29.
  • Sardanelli F, Podo F, Santoro F, Manoukian S, Bergonzi S, Trecate G, et al. Multicenter surveillance of women at high genetic breast cancer risk using mammography, ultrasonography, and contrast-enhanced magnetic resonance imaging. Invest Radiol. 2011;46:94–105.
  • Vreemann S, Rodriguez-Ruiz A, Nickel D, Heacock L, Appelman L, van Zelst J, et al. Compressed sensing for breast MRI: resolving the trade-off between spatial and temporal resolution. Invest Radiol. 2017;52:574–582.
  • Hernández ML, Osorio S, Florez K, Ospino A, Díaz GM. Abbreviated magnetic resonance imaging in breast cancer: a systematic review. Eur J Radiol Open. 2021;8:100307.
  • Warner E, Messersmith H, Causer P, Eisen A, Shumak R, Plewes D. Using magnetic resonance imaging to screen women at high risk for breast cancer: a systematic review. Ann Intern Med. 2008;148:671–679.
  • Evans DGR, Harkness EF, Howell A, Wilson M, Hurley E, Holmen MM, et al. Intensive breast screening in BRCA2 mutation carriers is associated with reduced breast cancer–specific and all-cause mortality. Hered Cancer Clin Pract. 2016;14:8.
  • Mann RM, Cho N, Moy L. Breast MRI: state of the art. Radiology. 2019;292:520–536.
  • Mann RM, Balleyguier C, Baltzer PA, Bick U, Colin C, Cornford E, et al. Breast MRI: EUSOBI recommendations for women’s information. Eur Radiol. 2015;25:3669–3678.
  • Monticciolo DL, Newell MS, Moy L, Niell B, Monsees B, Sickles EA. Breast cancer screening in women at higher-than-average risk: recommendations from the ACR. J Am Coll Radiol. 2018;15:408–414.
  • Gilbert FJ, Payne NR, Allajbeu I, Yit L, Vinnicombe S, Lyburn I, et al. Comparison of supplemental breast cancer imaging techniques: interim results from the BRAID randomized controlled trial. Lancet. 2025;405:1935–1944.
  • Youk JH, Gweon HM, Son EJ. Shear-wave elastography in breast ultrasonography: the state of the art. Ultrasonography. 2017;36:300–309.
  • Menzilcioğlu MS, Çitil S. Strain wave elastography imaging for the evaluation of pancreas in healthy volunteers. Eur J Ther. 2023;26:229–232.
  • Chamming’s F, Hangard C, Gennisson JL, Reinhold C, Fournier LS. Diagnostic accuracy of four levels of manual compression applied in supersonic shear wave elastography of the breast. Acad Radiol. 2021;28:481–486.
  • Wang ZL, Sun L, Li Y, Li N. Relationship between elasticity and collagen fiber content in breast disease: a preliminary report. Ultrasonics. 2015;57:44–49.
  • Mahmoud ZMS, El-Shinnawy MAM, Ali NSAA. Diagnostic role of shear wave elastography in differentiating benign from malignant breast masses. Egypt J Radiol Nucl Med. 2025;56:130.
  • Shahzad R, Fatima I, Anjum T, Shahid A. Diagnostic value of strain elastography and shear wave elastography in differentiating benign and malignant breast lesions. Ann Saudi Med. 2022;42:319–326.
  • Kim H, Lee J, Kang BJ, Kim SH. What shear wave elastography parameter best differentiates breast cancer and predicts its histologic aggressiveness? Ultrasonography. 2021;40:265–273.
  • Jia W, Luo T, Dong Y, Zhang X, Zhan W, Zhou J. Breast elasticity imaging techniques: comparison of strain elastography and shear-wave elastography. Ultrasound Med Biol. 2021;47:104–113.
  • Hong MJ, Cha JH, Kim HH, Shin HJ, Chae EY, Shin JE, et al. Second-look ultrasonography for MRI-detected suspicious breast lesions in patients with breast cancer. Ultrasonography. 2015;34:125–132.
  • Sauer ST, Geerling J, Christner SA, Schlaiß T, Kiesel M, Scherer-Quenzer AC, et al. The value of second-look ultrasound and mammography for assessment and biopsy of MRI-detected breast lesions. Acad Radiol. 2025;32:1818–1826.
There are 28 citations in total.

Details

Primary Language English
Subjects Radiology and Organ Imaging, Diagnostic Radiography
Journal Section Case Report
Authors

Emre Utkan Büyükceran 0000-0001-6912-7737

Ayça Seyfettin 0000-0002-8540-9432

Andelib Babatürk 0000-0002-8406-6159

Zeynep Eskalen This is me 0000-0001-7671-5131

Deniz Yamaç This is me 0000-0002-9385-3875

Submission Date October 14, 2025
Acceptance Date January 4, 2026
Publication Date March 27, 2026
DOI https://doi.org/10.65092/autfm.1802744
IZ https://izlik.org/JA83JP65WW
Published in Issue Year 2026 Volume: 79 Issue: 1

Cite

APA Büyükceran, E. U., Seyfettin, A., Babatürk, A., Eskalen, Z., & Yamaç, D. (2026). Contralateral Invasive Lobular Carcinoma Mimicking an Intramammary Lymph Node: A Case Report of MRI Detection and Elastography Differentiation in a Patient with Prior IDC. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 79(1), 1-7. https://doi.org/10.65092/autfm.1802744
AMA 1.Büyükceran EU, Seyfettin A, Babatürk A, Eskalen Z, Yamaç D. Contralateral Invasive Lobular Carcinoma Mimicking an Intramammary Lymph Node: A Case Report of MRI Detection and Elastography Differentiation in a Patient with Prior IDC. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2026;79(1):1-7. doi:10.65092/autfm.1802744
Chicago Büyükceran, Emre Utkan, Ayça Seyfettin, Andelib Babatürk, Zeynep Eskalen, and Deniz Yamaç. 2026. “Contralateral Invasive Lobular Carcinoma Mimicking an Intramammary Lymph Node: A Case Report of MRI Detection and Elastography Differentiation in a Patient With Prior IDC”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 79 (1): 1-7. https://doi.org/10.65092/autfm.1802744.
EndNote Büyükceran EU, Seyfettin A, Babatürk A, Eskalen Z, Yamaç D (March 1, 2026) Contralateral Invasive Lobular Carcinoma Mimicking an Intramammary Lymph Node: A Case Report of MRI Detection and Elastography Differentiation in a Patient with Prior IDC. Ankara Üniversitesi Tıp Fakültesi Mecmuası 79 1 1–7.
IEEE [1]E. U. Büyükceran, A. Seyfettin, A. Babatürk, Z. Eskalen, and D. Yamaç, “Contralateral Invasive Lobular Carcinoma Mimicking an Intramammary Lymph Node: A Case Report of MRI Detection and Elastography Differentiation in a Patient with Prior IDC”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 79, no. 1, pp. 1–7, Mar. 2026, doi: 10.65092/autfm.1802744.
ISNAD Büyükceran, Emre Utkan - Seyfettin, Ayça - Babatürk, Andelib - Eskalen, Zeynep - Yamaç, Deniz. “Contralateral Invasive Lobular Carcinoma Mimicking an Intramammary Lymph Node: A Case Report of MRI Detection and Elastography Differentiation in a Patient With Prior IDC”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 79/1 (March 1, 2026): 1-7. https://doi.org/10.65092/autfm.1802744.
JAMA 1.Büyükceran EU, Seyfettin A, Babatürk A, Eskalen Z, Yamaç D. Contralateral Invasive Lobular Carcinoma Mimicking an Intramammary Lymph Node: A Case Report of MRI Detection and Elastography Differentiation in a Patient with Prior IDC. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2026;79:1–7.
MLA Büyükceran, Emre Utkan, et al. “Contralateral Invasive Lobular Carcinoma Mimicking an Intramammary Lymph Node: A Case Report of MRI Detection and Elastography Differentiation in a Patient With Prior IDC”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 79, no. 1, Mar. 2026, pp. 1-7, doi:10.65092/autfm.1802744.
Vancouver 1.Emre Utkan Büyükceran, Ayça Seyfettin, Andelib Babatürk, Zeynep Eskalen, Deniz Yamaç. Contralateral Invasive Lobular Carcinoma Mimicking an Intramammary Lymph Node: A Case Report of MRI Detection and Elastography Differentiation in a Patient with Prior IDC. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2026 Mar. 1;79(1):1-7. doi:10.65092/autfm.1802744