Case Report
Year 2017,
, 183 - 186, 16.12.2017
Abstract
Bu olgu sunumunda bir aydır devam edip son iki haftadır șiddeti artan baș ağrısı, bulantı, kusma, ıșığa intolerans șikayetleri olan 52 yașında bir kadın hasta sunulmaktadır. Bir yıl önce meme kanseri tanısı alan hastanın kemoterapi ve radyoterapi tedavisi 6 ay önce tamamlanmıștır. Klinik, lomber ponksiyon ve ilk magnetik rezonans görüntüleme (MRG) bulguları ile meneningoensefalit düșünülerek empirik antibiyoterapi bașlanmıștır. Antibiyotik tedavisine yanıt alınamadığı için beyin omurilik sıvısında (BOS) sitolojik inceleme yapılmıș ve tekrarlanan MRG’de serebellumda lineer tarzda leptomeningeal tutulum görülmüștür. Klinik bulgular ve radyolojik görüntüleme sonucu ile meme kanserine bağlı leptomeningeal metastaz (LM) tanısı konulmuștur. Üç hafta yoğun bakım ünitesinde (YBÜ) takip edilen hasta kaybedilmiștir. Çok farklı klinik tablolar olușturabildiğinden dolayı tanıda gecikmeler yașanmaktadır. Bu vaka LM’in, meningoensefalit ile karıșabileceğini göstermesi bakımından dikkat çekicidir.
References
- 1. Kesari S, Batchelor TT. Leptomeningeal metastases. Neurol Clin 2003; 21: 25-66 2. Kaplan JG, DeSouza TG, Farkash A et al. Leptomeningeal metastases: Comparison of clinical features and laboratory data of solid tumors, lymphomas and leukemias. J Neurooncol. 1990;9:225–229 3. Rhun EL, Taillibert S ,Carcinomatous meningitis: Leptomeningeal metastases in solid tumors, , Surg Neurol Int. 2013; 4: 265– 288 4. Scott BJ, Kesar S, Leptomeningeal metastases in breast cancer, , Am J Cancer Res 2013;3:117-126 5. Le Rhun E. Prospective follow-up of a cohort of 112 patients with leptomeningeal metastases of breast cancer recruited from 2007-2011: Prognostic factors. Journal of clinical oncology: official journal of the American Society of Clinical Oncology 2012; 30 6. Groves MD. Advances in treating leptomeningeal metastases, Educational Book. Alexandria, Virginia: American Society of Clinical Oncology; 2008; 50–57 7. Jaeckle KA. Neoplastic meningitis from systemic malignancies: Diagnosis, prognosis, and treatment. Semin Oncol. 2006;33:312–323 8. Little JR, Dale AJ, Okazaki H. Meningeal carcinomatosis.Clinical manifestations. Arch Neurol. 1974;30:138–143 9. Olson ME, Chernik NL, Posner JB. Infiltration of the leptomeninges by systemic cancer.A clinical and pathologic study. Arch Neurol. 1974;30:122–137 10. Gonzalez-Vitale JC, Garcia-Bunuel R. Meningeal carcinomatosis. Cancer. 1976;37:2906–11 11. Glantz MJ, Cole BF, Glantz LK et al. Cerebrospinal fluid cytology in patients with cancer: minimizing false-negative results. Cancer 1998;82: 733-739 12. Leal T, Julie E, Leptomeningeal Metastasis: Challenges in Diagnosis and Treatment, Curr Cancer Ther Rev. 2011 ; 7; 319–327. 13. Teplyuk NM, Mollenhauer B, Gabriely G et al. MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity. Neuro Oncol 2012 Jun; 14: 689-700 14. Rosen ST, Aisner J, Makuch RW et al. Carcinomatous leptomeningitis in small cell lung cancer: A clinicopathologic review of the National Cancer Institute experience. Medicine (Baltimore) 1982;61:45–53 15. Mittl RL, Jr, Yousem DM. Frequency of unexplained meningeal enhancement in the brain after lumbar puncture. AJNR Am J Neuroradiol. 1994 15:633-688 16. Chamberlain MC. Neuraxis imaging in leptomeningeal metastasis: A retrospective case series. CNS Oncol. 2013 Mar;2:121128 17. Clarke JL, Perez HR, Jacks LM et al. Leptomeningeal metastases in the MRI era. Neurology. 2010;74:1449–1454 18. Gauthier H, Guilhaume MN, Bidard FC et al. Survival of breast cancer patients with meningeal carcinomatosis. Ann Oncol. 2010;21:2183–2187. 19. Dietemann JL, Correia Bernardo R, Bogorin A et al. Normal and abnormal meningeal enhancement: MRI features. J Radiol. 2005;86:1659–1683 20. Foo C.T., Burrel.L.M., An unusual presentation of carcinomatous meningitis Oxford Medical Case Reports, 2016;8, 159–162
Year 2017,
, 183 - 186, 16.12.2017
Abstract
References
- 1. Kesari S, Batchelor TT. Leptomeningeal metastases. Neurol Clin 2003; 21: 25-66 2. Kaplan JG, DeSouza TG, Farkash A et al. Leptomeningeal metastases: Comparison of clinical features and laboratory data of solid tumors, lymphomas and leukemias. J Neurooncol. 1990;9:225–229 3. Rhun EL, Taillibert S ,Carcinomatous meningitis: Leptomeningeal metastases in solid tumors, , Surg Neurol Int. 2013; 4: 265– 288 4. Scott BJ, Kesar S, Leptomeningeal metastases in breast cancer, , Am J Cancer Res 2013;3:117-126 5. Le Rhun E. Prospective follow-up of a cohort of 112 patients with leptomeningeal metastases of breast cancer recruited from 2007-2011: Prognostic factors. Journal of clinical oncology: official journal of the American Society of Clinical Oncology 2012; 30 6. Groves MD. Advances in treating leptomeningeal metastases, Educational Book. Alexandria, Virginia: American Society of Clinical Oncology; 2008; 50–57 7. Jaeckle KA. Neoplastic meningitis from systemic malignancies: Diagnosis, prognosis, and treatment. Semin Oncol. 2006;33:312–323 8. Little JR, Dale AJ, Okazaki H. Meningeal carcinomatosis.Clinical manifestations. Arch Neurol. 1974;30:138–143 9. Olson ME, Chernik NL, Posner JB. Infiltration of the leptomeninges by systemic cancer.A clinical and pathologic study. Arch Neurol. 1974;30:122–137 10. Gonzalez-Vitale JC, Garcia-Bunuel R. Meningeal carcinomatosis. Cancer. 1976;37:2906–11 11. Glantz MJ, Cole BF, Glantz LK et al. Cerebrospinal fluid cytology in patients with cancer: minimizing false-negative results. Cancer 1998;82: 733-739 12. Leal T, Julie E, Leptomeningeal Metastasis: Challenges in Diagnosis and Treatment, Curr Cancer Ther Rev. 2011 ; 7; 319–327. 13. Teplyuk NM, Mollenhauer B, Gabriely G et al. MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity. Neuro Oncol 2012 Jun; 14: 689-700 14. Rosen ST, Aisner J, Makuch RW et al. Carcinomatous leptomeningitis in small cell lung cancer: A clinicopathologic review of the National Cancer Institute experience. Medicine (Baltimore) 1982;61:45–53 15. Mittl RL, Jr, Yousem DM. Frequency of unexplained meningeal enhancement in the brain after lumbar puncture. AJNR Am J Neuroradiol. 1994 15:633-688 16. Chamberlain MC. Neuraxis imaging in leptomeningeal metastasis: A retrospective case series. CNS Oncol. 2013 Mar;2:121128 17. Clarke JL, Perez HR, Jacks LM et al. Leptomeningeal metastases in the MRI era. Neurology. 2010;74:1449–1454 18. Gauthier H, Guilhaume MN, Bidard FC et al. Survival of breast cancer patients with meningeal carcinomatosis. Ann Oncol. 2010;21:2183–2187. 19. Dietemann JL, Correia Bernardo R, Bogorin A et al. Normal and abnormal meningeal enhancement: MRI features. J Radiol. 2005;86:1659–1683 20. Foo C.T., Burrel.L.M., An unusual presentation of carcinomatous meningitis Oxford Medical Case Reports, 2016;8, 159–162
There are 1 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Articles |
| Authors | |
| Publication Date | December 16, 2017 |
| Published in Issue | Year 2017 |