Effect Of NaOH Concentration On The Degradation Properties Of CHA/PCL Composites For Bone Replacement Applications

Duygu Ege

doi:10.1501/Tipfak_0000000833

EN TR

Effect Of NaOH Concentration On The Degradation Properties Of CHA/PCL Composites For Bone Replacement Applications

Abstract

Amaç: NaOH konsantrasyonu ve bekletme süresinin ağırlıkça % 19 kalsine edilmemiș karbonlanmıș hidroksiapatit (CHA)/Poly- ε -kaprolakton (PCL)’nin kütle kaybına etkisinin incelenmesi NaOH uygulamasının ardından gerçekleștiren fosfatla tamponlanmıș salin (PBS) çalıșmasında, kompozitlerin biyolojik yıkımlarının analizi ve kemik grefti uygulanabilirliklerinin incelenmesi Gereç ve Yöntemler: CHA ıslak çökeltme yöntemi kullanılarak üretilmiștir. CHA/PCL kompozit, ikiz vidalı ekstrüzyon ve enjeksiyon kalıplama ile hazırlanmıștır. Ağırlıkça % 19 kalsine edilmemiș CHA/PCL’in biyolojik yıkım hızını arttırmak amacıyla, numuneler farklı sürelerde, çeșitli konsantrasyonlardaki NaOH solüsyonları (Sigma Aldrich, UK) ile muamele edilmiștir. Daha sonra biyolojik yıkım hızları PBS içinde analiz edilmiștir. Bulgular: NaOH konsantrasyonunun 3 M‘dan 5 M’a artması, NaOH ve PBS’de muhafaza edildikten sonra numunelerin % ağırlık kaybını arttırmıștır. Ancak, 5 M NaOH’da numuneleri 1 ve 3 gün bulundurmak % ağırlık değișimini etkilememiștir. Sonuç: NaOH konsantrasyonunun artması ile numunelerin biyolojik yıkımları hızlandırılmıștır. Ağırlıkça % 19 kalsine edilmemiș CHA/PCL’in 1 gün sureyle 3 M NaOH içinde muhafaza edilmesi, PBS çalıșmalarında daha kontrollü bir șekilde biyolojik yıkıma uğradıklarını göstermiștir.

Keywords

Poli-ε -kaprolakton, karbonatlı hidroksiapatit, NaOH muamelesi, biyolojik yıkım çalıșması, çift vidalı ekstrüzyon, enjeksiyon dökümü

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Details

Primary Language

Turkish

Subjects

Medical Biochemistry - Amino Acids and Metabolites

Journal Section

Research Article

Authors

Duygu Ege This is me
0000-0002-9922-6995
Türkiye

Publication Date

December 13, 2014

Submission Date

December 13, 2014

Acceptance Date

-

Published in Issue

Year 2013 Volume: 66 Number: 1

DOI

https://doi.org/10.1501/Tipfak_0000000833

IZ

https://izlik.org/JA33YN44ZW

APA

Ege, D. (2014). Effect Of NaOH Concentration On The Degradation Properties Of CHA/PCL Composites For Bone Replacement Applications. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 66(1), 1-5. https://doi.org/10.1501/Tipfak_0000000833

AMA

1.Ege D. Effect Of NaOH Concentration On The Degradation Properties Of CHA/PCL Composites For Bone Replacement Applications. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2014;66(1):1-5. doi:10.1501/Tipfak_0000000833

Chicago

Ege, Duygu. 2014. “Effect Of NaOH Concentration On The Degradation Properties Of CHA PCL Composites For Bone Replacement Applications”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 66 (1): 1-5. https://doi.org/10.1501/Tipfak_0000000833.

EndNote

Ege D (December 1, 2014) Effect Of NaOH Concentration On The Degradation Properties Of CHA/PCL Composites For Bone Replacement Applications. Ankara Üniversitesi Tıp Fakültesi Mecmuası 66 1 1–5.

IEEE

[1]D. Ege, “Effect Of NaOH Concentration On The Degradation Properties Of CHA/PCL Composites For Bone Replacement Applications”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 66, no. 1, pp. 1–5, Dec. 2014, doi: 10.1501/Tipfak_0000000833.

ISNAD

Ege, Duygu. “Effect Of NaOH Concentration On The Degradation Properties Of CHA PCL Composites For Bone Replacement Applications”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 66/1 (December 1, 2014): 1-5. https://doi.org/10.1501/Tipfak_0000000833.

JAMA

1.Ege D. Effect Of NaOH Concentration On The Degradation Properties Of CHA/PCL Composites For Bone Replacement Applications. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2014;66:1–5.

MLA

Ege, Duygu. “Effect Of NaOH Concentration On The Degradation Properties Of CHA PCL Composites For Bone Replacement Applications”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 66, no. 1, Dec. 2014, pp. 1-5, doi:10.1501/Tipfak_0000000833.

Vancouver

1.Duygu Ege. Effect Of NaOH Concentration On The Degradation Properties Of CHA/PCL Composites For Bone Replacement Applications. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2014 Dec. 1;66(1):1-5. doi:10.1501/Tipfak_0000000833

Cited By

Polycaprolactone fibrous electrospun scaffolds reinforced with copper doped wollastonite for bone tissue engineering applications

Journal of Biomedical Materials Research Part B: Applied Biomaterials

https://doi.org/10.1002/jbm.b.34729

NaOH Konsantrasyonunun ve NaOH Bekletme Süresinin Kemik Greftlerinde Kullanılan CHA/PCL Kompozitlerinin Biyolojik Yıkımına Etkisi

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Effect Of NaOH Concentration On The Degradation Properties Of CHA/PCL Composites For Bone Replacement Applications

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Polycaprolactone fibrous electrospun scaffolds reinforced with copper doped wollastonite for bone tissue engineering applications