Malign Plevral Efüzyonlarda Leptin: Yeni Bir Markır Olabilir mi?

Year 2011, , 127 - 131, 01.03.2011

Serap Duru , Zeynep Sönmez - Saygıdeğer Alper Dilli Günnur Dikmen Özlem Sever Sadık Ardınç

https://doi.org/10.1501/Tipfak_0000000796

Abstract

Keywords

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Malign Plevral Efüzyonlarda Leptin: Yeni Bir Markır Olabilir mi?

Abstract

Amaç: Bazı malign ve benign hastalıklar plevral efüzyona yol açabilir. Bu çalışmada, malign ve malign olmayan plevral efüzyonlarda, serum ve plevral sıvıda leptin düzeyleri arasındaki farkı araştırmayı amaçladık.Yöntemler: Çalışmaya yaş ortalaması ve vücut kitle indeksi (VKI) benzer olan malign (n=20), malign olmayan plevral efüzyonlu (n=20) hastalar ve sigara içmeyen sağlıklı bireyler (n=20, kontrol grubu) alındı. Çalışmaya alınan 3 grupta serumda leptin, plevral efüzyonlu hasta gruplarında ise plevral sıvıda leptin düzeylerine bakıldı. Bulgular: Malign plevral efüzyonlu hasta grubunda hem kontrol hem de malign olmayan plevral efüzyonlu hasta grubuna göre serum ve plevral sıvı leptin düzeylerinin anlamlı olarak yüksek olduğu görüldü (p < 0.001). Kadın ve erkek hastalar arasında plevral sıvı leptin düzeyleri arasında farklılık bulunmazken (p=0.097), serum leptin düzeyinin kadın hastalarda daha yüksek (p < 0.001) olduğu görüldü.Sonuç: Serum ve plevral sıvı leptin düzeyinin artması, malign plevral efüzyonlarda leptinin kullanılabilir yeni bir markır olabileceğini göstermektedir.

Keywords

Leptin, malignite, plevral efüzyon

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