Assessment Of Neurohumoral Regulation And Oxidative Stress Indices In Patients With Postinfarction Cardiosclerosis
Abstract
Keywords
References
- Ageev F.T. Role of endothelial dysfunction in the development and progression of cardio- vascular disease. Journal of Heart Failure. 2003; № 4, p. 22-24.
- Cowburn P.J., Cleland J.G.F. Endothelin an- tagonists for chronic heart failure: do they have a role? Eur. Heart J. 2001; Vol .22, № 19, P.1772-1784.
- Guidelines for the diagnosis and treatment of Chronic Heart Failure: full text (update 2008) The Task Force for the diagnosis and treatment of CHF of the European Society of Cardiology / / (European Heart Journal doi: 10.1093/eurheartj/ehn 309).
- Maisel A., Komjada M. E. Expanding role of Brain Natriuretic Peptide in the manage- ment of heart failure. Findings of the Euro- pean-North American Consensus Group on BNP. European Society of Cardiology. Heart Failure 2007, 4, P.12 (Satellite Symposium).
- Keith M., Jeejeebhoy K., Sole M. The Role of Oxidative Stress in Congestive Cardiac Fail- ure / / Heart Failure Summar Fall 1999; - P. 179-187.
- Landmesser U., Drexler H. Oxidative stress, the renin-angiotensin system, and athero- sclerosis / / Eur. Heart J. - 2003. - Vol. 5 (Suppl. A). - P. 3.7
- Fischer D., Rossa S., Landmesser U. et al. En- dothelial dysunctionin patients with chronic heart failure is independently associated with increased incidence of hospitalisation, cardiotransplantation, or death. Eur. Heart J. 2005; Vol.26: P.65-69.
- Paulus W.J. The role of nitric oxide in the fail- ing heart / / Heart Fail.Rev.-2001.-Vol.6, № 2 - P.105-118.
- ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med 2002; 166:111–117.
- Ferrari R., Bachetti T., Agnoletti L. et al. En- dothelial function and dysfunction in heart failure. Eur. Heart J. 1998, 19 (Suppl. G): P. 41-48.
- Noguchi N., Nishino K., Niki E. Antioxi- dant action of the antihypertensive drug, carvedilol, against lipid peroxidation / / Bio- chem. Pharmacol. 2000; Vol .59 № 9: - P. 1069-1076.
- Sugawara J., Maeda S., Otsuki T., Tanabe T. et al. Effects of nitric oxide synthase inhibi- tor on decrease in peripheral arterial stiffness with acute low-intensity aerobic exercise // Hypertension. 2004. Aug; 44 (2): - P. 119- 120.
Postinfarktüs Kardiyosklerozlu Hastalarda Oksidatif Stres Parametreleri ve Nörohumoral Regülasyonun Değerlendirilmesi
Abstract
Amaç: Kronik kalp yetmezlikli hastalarda oksidatif stres ve natriüretik peptid seviyelerini
değerlendirmeyi amaçladık
Metodlar: Kalp yetmezliği ile komplike olmuş postinfarktüs kardiosklerozlu 52 erkek
hastada(yaş:38-60), NP-NT-pro BNP, malondialdehid-benzeri aktivite (MDA), enzimler-katalaz
ve superoksit dismutaz (SOD), NO metabolitleri (NO2-NO3), NADPH-diaforaz(eNOS), nitrat
redtiktaz(INOS) ve peroksinitrat (ONOO) ın kan plazma seviyeleri ölçüldü ve 6 dakika yürüme testi
uygulandı.
Sonuçlar: Kontrol grubu ile kıyaslandığmda NYHA sınıf 2-3 hastalarda sırasıyla bazal NT-proBNP
seviyelerinin 2,4 ve 3,4 kat, MDA seviyelerinin 2,5 ve 3,5 kat, ONOO formunun 2 ve 3,1 kat, SOD
indeksinin %35 ve %44,7 oranında arttığı saptandı. NYHA sınıf 2-3 de kontrol grubu ile kıyasla
sırasıyla eNOS %24,6 ve %42,6, NO metabolitleri %28,6 ve %45,4, katalaz seviyesi %37 ve %46,3
arttığı görüldü.
Tartışma: NT-proBNP seviyelerinin NYHA sınıfı ve oksidatif stresin ciddiyeti ile ilişkili olduğu
gösterilmiştir. Farklı NYHA sımflarına bağlı olarak natriüretik peptid seviyesinin ve oksidatif stres
ürünlerinin ki bvınlar artmış MDA ürünleri ve azalmış antioksidan enzimler ve NO metabolitleri
olup, bunların artmış olduğunu saptadık.
Keywords
References
- Ageev F.T. Role of endothelial dysfunction in the development and progression of cardio- vascular disease. Journal of Heart Failure. 2003; № 4, p. 22-24.
- Cowburn P.J., Cleland J.G.F. Endothelin an- tagonists for chronic heart failure: do they have a role? Eur. Heart J. 2001; Vol .22, № 19, P.1772-1784.
- Guidelines for the diagnosis and treatment of Chronic Heart Failure: full text (update 2008) The Task Force for the diagnosis and treatment of CHF of the European Society of Cardiology / / (European Heart Journal doi: 10.1093/eurheartj/ehn 309).
- Maisel A., Komjada M. E. Expanding role of Brain Natriuretic Peptide in the manage- ment of heart failure. Findings of the Euro- pean-North American Consensus Group on BNP. European Society of Cardiology. Heart Failure 2007, 4, P.12 (Satellite Symposium).
- Keith M., Jeejeebhoy K., Sole M. The Role of Oxidative Stress in Congestive Cardiac Fail- ure / / Heart Failure Summar Fall 1999; - P. 179-187.
- Landmesser U., Drexler H. Oxidative stress, the renin-angiotensin system, and athero- sclerosis / / Eur. Heart J. - 2003. - Vol. 5 (Suppl. A). - P. 3.7
- Fischer D., Rossa S., Landmesser U. et al. En- dothelial dysunctionin patients with chronic heart failure is independently associated with increased incidence of hospitalisation, cardiotransplantation, or death. Eur. Heart J. 2005; Vol.26: P.65-69.
- Paulus W.J. The role of nitric oxide in the fail- ing heart / / Heart Fail.Rev.-2001.-Vol.6, № 2 - P.105-118.
- ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med 2002; 166:111–117.
- Ferrari R., Bachetti T., Agnoletti L. et al. En- dothelial function and dysfunction in heart failure. Eur. Heart J. 1998, 19 (Suppl. G): P. 41-48.
- Noguchi N., Nishino K., Niki E. Antioxi- dant action of the antihypertensive drug, carvedilol, against lipid peroxidation / / Bio- chem. Pharmacol. 2000; Vol .59 № 9: - P. 1069-1076.
- Sugawara J., Maeda S., Otsuki T., Tanabe T. et al. Effects of nitric oxide synthase inhibi- tor on decrease in peripheral arterial stiffness with acute low-intensity aerobic exercise // Hypertension. 2004. Aug; 44 (2): - P. 119- 120.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | March 1, 2009 |
| Published in Issue | Year 2009 |