Analysis of Prognostic Factors in Bladder Carcinoma Treated With Radical Cystectomy

Abstract

Keywords

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Mesane Kanserinde Radikal Sistektomi Sonrası Prognostik Faktörlerin Değerlendirilmesi

Abstract

Amaç: İnvaziv mesane tümörlerinin tedavisinde bugün için standart tedavi yöntemi radikal sistektomidir. Bu çalışmada, invaziv mesane kanseri nedeniyle radikal sistektomi yapılan 241 hastadaki cerrahi deneyimlerimiz ve uzun dönem takip sonuçlarımız sunulmaktadır. Materyal ve Metodlar: Kliniğimizde 1990 yılından itibaren invaziv mesane kanseri nedeniyle radikal sistektomi yapılan 241 hastanın (214 erkek, 27 bayan) kayıtları retrospektif olarak incelenmiştir. Klinik ve patolojik verilerle birlikte, hastaların takip sonuçları da değerlendirilmiştir. Kategorik değişkenler arasındaki ilişkilerin araştırılmasında ki-kare testi kullanılmıştır. Sağkalım oranları Kaplan-Meier metodu ile, hastaların özellikleri ve sağkalım arasındaki ilişki de log-rank testi kullanılarak belirlenmiştir. Bulgular: Üriner diversiyon tipi olarak 97 hastaya ileal konduit, 58 hastaya ileum segmenti ile ortotopik üriner diversiyon, 43 hastaya mainz pouch II, 22 hastaya üreterokutanostomi ve 21 hastaya ise üreterosigmoidostomi uygulanmıştır. Hastaların ortalama yaşı 59.8 (29 ve 83 yıl arasında) yıldır. Patolojik evrelere göre 5 yıllık genel sağkalım oranları pT0, pT1, pT2, pT3 ve pT4 için sırasıyla %72.9, %77.6, %48.0, %25.4 ve %28.8 olarak tahmin edilmiştir (Şekil 1; log-rank test, p

Keywords

• mesane kanseri, radikal sistektomi, prognoz

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