Comparison of Angiotensin Converting Enzyme Inhibitors and Beta Blockers in Prevention of Atrial Fibrillation Recurrences After Electrical Cardioversion Elektriksel Kardiyoversiyon Sonrasında Atriyal

Abstract

Keywords

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Elektriksel Kardiyoversiyon Sonrasında Atriyal Fibrilasyon Nükslerinin Önlenmesinde Anjiyotensin Dönüştürücü Enzim İnhibitörleri ve Beta Blokerlerin Karşılaştırılması

Abstract

Amaç: Atriyal fi brilasyonun (AF) elektriksel kardiyoversiyonu sonrasında, anjiyotensin dönüştürücü enzim (ACE) inhibitörleri ve beta blokerlerin atriyal yapısal ve elektriksel remodeling’ i azaltmak suretiyle AF nükslerini azalttığı gösterilmiştir. Bu çalışmada, kardiyoversiyon sonrasında ACE inhibitörü cilazapril ve beta bloker metoprolol’ ün sinüs ritmi idamesindeki etkileri karşılaştırıldı. Hastalar ve Yöntem: Çalışmaya persistan AF’si olup başarılı kardiyoversiyon yapılan 120 hasta alındı. Kardiyoversiyon sonrasında hastalar 3 gruba randomize edildi. Grup I’ e (n=41) amiodaron, Grup II’ ye (n=41) amiodaron+metoprolol, Grup III’ e (n=38) amiodaron+cilazapril verildi. Çalışmanın primer sonlanım noktası AF nüks oranları ve AF nüksü görülenlerde nükse kadar geçen zaman idi. Bulgular: Bir yıllık takip sonunda gruplar arasında sinüs ritmi idamesi arasında anlamlı fark saptanmadı (Kaplan Meier analizi, sırasıyla %24, %37 and %26; log rank=0.3). AF nüks zamanları açısından da gruplar arasında fark gözlenmedi. Sonuç: Amiodaron, amiodaron+metoprolol veya amiodaron+cilazapril tedavilerinin AF nüksü üzerine etkileri benzer bulunmuştur

Keywords

• Atriyal fi brilasyon, kardiyoversiyon, anjiyotensin dönüştürücü enzim inhibitörleri, beta blokerler

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