Clinical characteristics, complications and prognosis of seventy-nine measles cases

Year 2006, , 98 - 103, 01.03.2006

Tuğba Hirfanoğlu Gönül Tanır Candemir Karacan Neşe Göl

https://doi.org/10.1501/Tipfak_0000000201

Abstract

Aim: To investigate the age distribution, clinical presentations, laboratory and radiological findings, complications and prognosis of measles in children.
Materials and Methods: The children with the clinical diagnosis of measles which was confirmed
by a sensitive enzyme immunoassay for measles IgM antibody were evaluated comprehensively
aspect to complication of measles (i.e. pneumonia, otitis media, encephalitis).
Results: The ages of the 79 patients with measles ranged from 1 to 180 months. The severity of
the disease was significantly correlated with the younger age (p<0.001), higher levels of blood
neuthrophil counts and serum C-Reactive Protein (CRP) (p<0.05). The most common complications were pneumonia (75%) and encephalitis (9%). Three (3,8%) patients died due to the complications.
Conclusion: It was found that the severity of measles and the rate of complications are high
especially in infancy. Secondary bacterial pneumonia is the most common complications and
also responsible for the severity of measles. Acute measles encephalitis is not infrequent. Infancy,
very severe pneumonia, malnutrition and compromised immunity are the major factors which
increase mortality.

Keywords

measles, children, complications

Yetmişdokuz kızamık olgusunda klinik özellikler, komplikasyonlar ve prognoz

Abstract

Amaç: Kızamığın çocuklarda yaş dağılımını, klinik ve laboratuar özelliklerini, radyolojik bulgularını,
yan etkilerini ve prognozu değerlendirmek amaçlandı.
Gereç ve Yöntem: Klinik olarak kızamık tanısı konulan ve kızamık IgM antikor mikroELISA yöntemi ile de tanısı kesinleşen olgular kızamığın yan etkileri (alt solunum yolu enfeksiyonu, orta
kulak iltihabı, ensefalit) açısından ayrıntılı olarak değerlendirildi.
Bulgular: Yetmiş dokuz olgunun yaşları 1–180 ay arasında değişmekteydi. Hastalığın şiddeti yaşın
küçük olması (p<0.001), kan nötrofil sayısındaki ve CRP’deki yükseklik ile (p<0.05) ciddi olarak
ilişkili bulundu. En sık görülen yan etki pnömoni (%75) ve ensefalit (%9) idi. Üç (%3,8) olgu kızamık
yan etkilerinden dolayı kaybedildi.
Tartışma: Özellikle bebeklik dönemindeki çocukların, kızamığın şiddeti ve yan etkileri açısından
daha duyarlı oldukları saptandı İkincil bakteriyel alt solunum yolu enfeksiyonu oldukça sık ve
ayrıca hastalığın ciddiyetinden sorumlu faktör olarak saptandı. Akut kızamık ensefalitinin de
düşünüldüğü kadar ender olmadığı görüldü. Bebeklik dönemi, çok ciddi alt solunum yolu, malnütrisyon ve immun baskılanma mortaliteyi artıran büyük risk faktörleri olarak saptandı.

Keywords

kızamık, çocuk, yan etkiler

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