Safra oluşumunda rol oynayan transport proteinleri Transport proteins in bile production

Abstract

Keywords

• -

Safra oluşumunda rol oynayan transport proteinleri Transport proteins in bile production

Abstract

Son yıllarda safra oluşumuyla ilgili yeni görüşler ortaya çıkmış ve yeni bilgiler ışığında hastalıkların oluşum mekanizmaları aydınlanmaya başlamıştır. Bu derlemede, safra oluşumunda rol oynayan taşıyıcı proteinleri tanımlamak ve bugüne kadar bu konuda elde edilmiş olan bilgi birikimini sun- mak amaçlanmıştır

Keywords

• safra oluşumu, transport proteinler, kolestaz

References

1. Saunders WB. editor. Guyton & Hall Tıbbi Fizyoloji. İstanbul: Nobel Tıp Kitabevi, 1996; p.886.
2. Champe PC, Harvey RA. editors. Lippincott’s Biyokimya. İstanbul: Nobel Tıp Kitabevi, 1997; p. 210-213.
3. Reichen J. The role of the sinusoidal endothelium in liver function. News Physiol. Sci. 1999; 14:117-21.
4. Feldman M, Schorschmidt BF, Sleiseger MH. editors. Gastrointestinal and Liver Disease. Pheladelphia/London:Saunders, 1998; p.937-48.
5. Meier PJ. Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile. Am. J. Physiol. Gastrointest. Liver Physiol. 1995; 269:G801-G12.
6. Groothuis GM, Hardonk MJ, Keulemans KP et al. Autoradiographic and kinetic demonstration of acine heterogeneity of taurocholate transport. Am.J.Physiol. Gastrointest. Liver Physiol. 1982; 243:G455-G62.
7. Hagenbuch B, Steiger B, Foguet M et al. Functional expression cloning and characterization of the hepatocyte Na/bile acid cotransport system. Proc. Natl. Acad. Sci. USA.1991; 88:10629-33.
8. Cattori V, Eckhardt U, Hagenbuch B. Molecular cloning and functional characterization of two alternatively sliced Ntcp isoforms from Mouse liver. Biocim. Biophys. Acta. 1999; 1445:154-59.

9. Kramer W, Stengelin S, Baringhaus KH et al. Substrate specificity of the ileal and the hepatic Na/bile acid cotransporters of the rabbit 1. transport studies with membrane vesicles and cell lines expressing the cloned transporters. J. Lipid Res. 1999; 40:1604-17.
10. Hagenbuch B, Meier PJ. Molecular cloning chromosomal localization and function characterization of human liver Na/bile acid cotransporter. J. Clin. Invest. 1994; 93:1326-31.
11. Meier PJ, Eckhardt U, Schroder A, et al. Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver. Hepatology. 1997; 26:1667-77.
12. Hardikar W, Anonthanarayenan M, Suchy FJ. Differantial oncogenic regulation of basolateral and canalicular bile acid transport proteins in rat liver. J. Biol. Chem. 1995; 270:20841-46.
13. Suchy FJ, Bucuvalas JC, Goodrich AL et al. Taurocholate transport and Na-K-ATP ase activity in fetal and liver plasma membrane vesicles. Am. J. Physiol. Gastrointest. Liver Physiol. 1986; 251:G665-73.
14. Gren RM, Gollon JL, Hagenbuch B, et al. Regulation of hepatocyte bile salt transporters diving hepatic regeneration. Am.J.Physiol. Gastrointest. Liver Physiol. 1997; 273:G621-G27.
15. Hagenbuch B. Scharschmidt BF, Meier PJ. Effect of antisense oligonucleotides on the expression of hepatocellular bile acid and organic anion uptake systems in Xenopus laevis oocytes. Biochem.J. 1996; 316:901-4
16. Keng VW, Yagi H, Ikvva M, et al. Homebox gene Hex is essential for onset of Mouse embrionic liver development and differentiation of the monocyte lineage. Biochem. Biophys. Res. Common. 2000; 276:1155-61
17. Traziner M, Arrese M, Lee YH et al. Endotoxin downregulates rat hepatic Ntcp gene expression via decreased activity of critical transcription factors. J.Clin.Invest. 1998; 101:2092-100.
18. Shih DQ, Busen M, Sehayek E et al. Hepatocyte nuclear factor-lx is an essential regulator of bile acid and plasma cholesterol metabolism. Nat.Genet. 2001; 27:375-82
19. Hayhurst GP, Lee YH, Lambert G et al. Hepatocyte nuclear factor 4 x (nuclear factor 2 A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol.Cell.Biol. 2001; 21:1393-403.
20. Rausa FM, Tan Y, Zhou H et al. Elevated levels of hepatocyte nuclear factor 3B in mouse hepatocytes influence expression of genes involved in bile acid and glucose homeostasis. Mol. Cell. Biol. 2000; 20:8264-82.
21. Sinal CJ, Tohkin M, Miyata M et al. Targeted disruption of the nuclear receptor FXR / BAR impairs bile acid and lipid homeostasis. Cell. 2000; 102:731-44.
22. Dranoff JA, Mc Clure M, Burgstahler AD et al. Short term regulation of bile acid uptake by microfilament – dependent translocation of rat Ntcp to the plasma membrane. Hepatology. 1999; 30:223-29.
23. M. Trauner. Genetic disorders and molecular mechanism in cholestatic liver disease. Semin. Gastrointest. Dis. 2001; 12:66-88.
24. Glawy JS, Wu SM, Wang PJ et al. Down-regulation by extracellular ATP of rat hepatocyte organic anion transport is mediated by serine phosphorylation of Oatp1. J.Biol.Chem. 2000;275:1479-84.
25. Lee JL, Boyer JL. Molecular alterations in hepatocyte transport mechanism in acquired cholestatic liver disorders. Semin.Liver Dis.2000;20:373-84.
26. CuimY, König J, Leier I et al. Hepatic uptake of bilinubin and its conjugates by the human organic anion transporting polipeptide SLC 21A6. J.Biol.Chem. 2001;276:9626-30.
27. Kullack-Ublick GA, Beuers U, Fahney C et al. Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene. Hepatology. 1997;26:991- 997.
28. König J, Rost D, Cui Y et al. Characterization of the human multidrug resistance protein isoform MRP-3 localized to the basolateral hepatocyte membrane. Hepatology. 1999;29:1156-63.
29. Wilton JC, Mattheus GM, Burgoyre RD et al. Flourescent choleretic and bile salt take different paths across the hepatocyte: transcytosis of glycolithocholate leads to on extensive redistribution of annexin II. J.Cell Biol. 1994; 127:401-10.
30. El Seaidy AZ, Mills CO, Elias E et al. Lack of evidence for vesicle trafficking of flourescent bile salts in rat hepatocyte couplets. Am.J.Physiol. Gastrointest. Liver Physiol. 1997;272:G298-G309
31. Strautnikes SS, Bull LN, Knisely AS et al. A gene encoding a liver-spesific ABC transporter is mutaded in progressive familial intrahepatic cholestasis. Nat.Genet. 1998;20:233-38.
32. Wang R, Salem M, Yousef IM et al. Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis. Proc.Natl.Acad.Sci.USA. 2001;98:2011-16.
33. Stieger B, Fattinger K, Madon J et al. Drug and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump of rat liver. Gastroentorology. 2000;118:422-30.
34. Kartenbeck J, Leuschner U, Mayer R et al. Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson Syndome. Hepatology. 1996; 23:1061-6.
35. De Vree JM, Jacquemin E, Sturm E et al. Matation in the MDR 3 gene cause progressive familial intrahepatic cholestasis. Proc.Natl. Acad.Sci.USA. 1998;95:282-87.
36. Kamisako T, Kobayashi Y, Takeuchı K et al. Recent advances in bilirubin metabolism research: the molecular mechanism of hepatocyte bilirubin transport and its clinical relevance. J. Gastroenterol. 2000; 35:659-664.
37. Meier PJ, Stieger B. Bile salt transporter. Annu. Rev. Physiol. 2002; 64:635-61.
38. Takikawa H. Hepatobiliary transport of bile acids and organic anions. J. Hepatobiliary Pancreat. Surg. 2002; 9:443-447.
39. Trauner M, Boyner JL. Bile salt transporters: molecular characterization, function, and regulation. Physiological Reviews. 2003,83(2).633-71.