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Karaciğer Kitlelerinin Benign-Malign Ayrımında Difüzyon Ağırlıklı Sekansın Önemi

Year 2013, Volume: 66 Issue: 1, 7 - 13, 01.01.2013
https://doi.org/10.1501/Tipfak_0000000834

Abstract

Purpose: We investigated the diagnostic value of diffusion weighted imaging and apperent diffusion coefficient (ADC) mapping on differential diagnosis of benign and malignant focal liver masses. Materials And Metods: Diffusion - weighted MR imaging sequence was applied on 34 patients with a focal liver mass before contrast enhanced imaging. Diffusion - weighted images were obtained by applying 3 diffusion gradients at b level (b=50, b=400, b=800 s/mm2) with single shot echo-planar spin in axial plan in 1.5 Tesla MR tool. Average ADC values were determined by placing ROI at the size of 1 cm on average over ADC maps. Results: 62 lesions (46 benign, 16 malign) greater than 1 cm, in size were evaluated. Average ADC value of 46 benign lesions was 2.17±0.55 x 10-3 mm2/s and varied between (0,98 x 10-3 mm2/s 2.65 ± 0.54 x 10-3 mm2/s) and average ADC value of 16 malignant lesion was 0.84± 0.40 x 10-3 mm2/s (0.14 x 1010-3 mm2/s -1.32 x 10-3 mm2/s). Conclusion: Diffusion - weighted MR imaging and comparison of ADC values provide additional information in differentiating benign and malignant focal liver masses and particularly help us in differential diagnosis of patients to whom we cannot deliver IV contrast

References

  • Koh D, Collins D. Diffusion Weighted MRI in the Body: Applications and Challenges in Oncology. Am J Roentgenol 2007;188:1622-1635.
  • Reimer P, Saini S et al. Clinical application of abominal echoplanar imaging (EPI):optimization using a retrofitted EPI system. J Comput Asist Tomogr 1994;18:673-679.
  • Stejskal EO, Taner JE. Spin diffusion measurements: spin-echo in the 10. Hussain SM, Semelka RC. Liver presence of a time dependent field gradient. J Chem Phys 1965;42:288- 292.
  • Ichikawa T, Haradome H, Hachiya J, et al. Diffusion-weighted single shot echoplanar sequence: detection and characterization of focal hepatic lesion. AJR 1998;170:397-402.
  • Kim T, Murakami T, Takahashi S.Diffusion weighted single shot echo- planar MR imaging for liver disease. Am J Roentgenol 1999;173:393-398.
  • Namimoto T, Yamashita Y, et al. Focal Liver Masses: Characterization with Diffusion-weighted Echo-Planar MR Imaging. Radiology 1997;204:739- 744.
  • Turgut AT, Akhan O, et al. Sonographic Spectrum of Hydatid Disease. Ultrasound Quarterly 2008;24:17-19.
  • Taouli B, Koh D, et al. Diffusion- weighted MR Imaging of the Liver. Radiology 2010; 254: 47-66.
  • Shaid H. Liver MRI Correlation with Other Imaging Modalities and Histopathology. Springer; 2007;1:16-26 masses. Magn Reson Imaging Clin N Am 2005;13:255-275.
  • Inan N, Arslan A, et al. Diffusion- weighted MR imaging in the Differantial Diagnosis of Simple and Hydatid Cysts of the Liver. AJR 2007;189:1031-1036.
  • Touli B, Vilgrain V, Dumont E, et al. Evaluation of liver diffusion isotrophy and characterization of focal hepatic lesion with two single shot echo-planar MR imaging sequences: prospective study in 66 patients. Radiology 18. Kumar V, Cotran R, Robbins S, Basic 2003;226:71-78.
  • Hussain SM, Terkivatan T, Zondervan PE, et al. Focal Nodular Hyperplasia: a spectrum of findings at state of the art MR imaging, ultrasound, CT and pathology. Radiographics 2004;24:3-19.
  • Finley A, Hosey J, Noone T, et al. Multiple focal nodular hyperplasia syndrome: diagnosis with dynamic, gadolinium-enhanced MRI. MRM 2005; 23:511-513.
  • Chan JH, Tsui EY, Luk SH et al. Diffusion-weighted MR imaging of the liver: distinguishing hepatic abscess from cyctic or necrotic tumor. Abdominal Imaging 2001; 26:161-165.
  • Holzapfel K, Rummeny E, Gaa J. Diffusion-weighted MR imaging of hepatic abscesses: possibility of different apparent diffusion coefficient (ADC)-values in early and mature abscess formation. Abdominal Imaging 2007; 32:538-539.
  • Müller MF, Prasad P, Siewert B. Abdominal diffusion mapping with use of a whole-body echo-planar system. Radiology 1994;190:475-483. Pathology. 6th ed. W. B. Saunders Company;2005;19:607-643.

Karaciğer Kitlelerinin Benign-Malign Ayrımında Difüzyon Ağırlıklı Sekansın Önemi

Year 2013, Volume: 66 Issue: 1, 7 - 13, 01.01.2013
https://doi.org/10.1501/Tipfak_0000000834

Abstract

Amaç: Karaciğerin fokal kitlelerinin benign-malign ayrımında difüzyon ağırlıklı görüntülemenin ve görünen katsayı (ADC) değerlerinin tanıya katkısını araștırdık. Gereç ve Yöntem: Karaciğer kitlesi olan 34 hastaya kontrastlı inceleme öncesi difüzyon ağırlıklı MR görüntüleme sekansı uygulandı. 1,5 Tesla MR cihazında aksiyal planda, “single shot echoplanar spin” ile 3 farklı b değerinde (b=50, b=400, b=800 s/mm2) difüzyon gradiyentleri uygulanarak difüzyon ağırlıklı görüntüler elde edildi. ADC haritaları üzerinden ortalama 1 cm boyutunda ROI yerleștirilerek ortalama ADC değerleri belirlendi. Bulgular: Boyutu 1cm’den büyük olan 62 lezyon (46 benign,16 malign) değerlendirildi. 46 benign lezyonun ortalama ADC değeri 2.17±0.55 x 10-3 mm2/s (0,98 x 10-3 mm2/s - 2,65±0.54 x 10-3 mm2/s) ,16 malign lezyonun ortalama ADC değeri ise 0,84±0.40 x 10-3 mm2/s (0,14±0.01 x 10-3 mm2/s -1,32 x 10-3 mm2/s) idi. Sonuç: Fokal karaciğer kitlelerinin benign-malign ayrımında difüzyon ağırlıklı MR görüntüleme ve ADC değerlerinin karșılaștırılması ek bilgiler sağlamakta, özellikle IV kontrast veremediğimiz hastalarda ayırıcı tanıda bize yardımcı olmaktadır.

References

  • Koh D, Collins D. Diffusion Weighted MRI in the Body: Applications and Challenges in Oncology. Am J Roentgenol 2007;188:1622-1635.
  • Reimer P, Saini S et al. Clinical application of abominal echoplanar imaging (EPI):optimization using a retrofitted EPI system. J Comput Asist Tomogr 1994;18:673-679.
  • Stejskal EO, Taner JE. Spin diffusion measurements: spin-echo in the 10. Hussain SM, Semelka RC. Liver presence of a time dependent field gradient. J Chem Phys 1965;42:288- 292.
  • Ichikawa T, Haradome H, Hachiya J, et al. Diffusion-weighted single shot echoplanar sequence: detection and characterization of focal hepatic lesion. AJR 1998;170:397-402.
  • Kim T, Murakami T, Takahashi S.Diffusion weighted single shot echo- planar MR imaging for liver disease. Am J Roentgenol 1999;173:393-398.
  • Namimoto T, Yamashita Y, et al. Focal Liver Masses: Characterization with Diffusion-weighted Echo-Planar MR Imaging. Radiology 1997;204:739- 744.
  • Turgut AT, Akhan O, et al. Sonographic Spectrum of Hydatid Disease. Ultrasound Quarterly 2008;24:17-19.
  • Taouli B, Koh D, et al. Diffusion- weighted MR Imaging of the Liver. Radiology 2010; 254: 47-66.
  • Shaid H. Liver MRI Correlation with Other Imaging Modalities and Histopathology. Springer; 2007;1:16-26 masses. Magn Reson Imaging Clin N Am 2005;13:255-275.
  • Inan N, Arslan A, et al. Diffusion- weighted MR imaging in the Differantial Diagnosis of Simple and Hydatid Cysts of the Liver. AJR 2007;189:1031-1036.
  • Touli B, Vilgrain V, Dumont E, et al. Evaluation of liver diffusion isotrophy and characterization of focal hepatic lesion with two single shot echo-planar MR imaging sequences: prospective study in 66 patients. Radiology 18. Kumar V, Cotran R, Robbins S, Basic 2003;226:71-78.
  • Hussain SM, Terkivatan T, Zondervan PE, et al. Focal Nodular Hyperplasia: a spectrum of findings at state of the art MR imaging, ultrasound, CT and pathology. Radiographics 2004;24:3-19.
  • Finley A, Hosey J, Noone T, et al. Multiple focal nodular hyperplasia syndrome: diagnosis with dynamic, gadolinium-enhanced MRI. MRM 2005; 23:511-513.
  • Chan JH, Tsui EY, Luk SH et al. Diffusion-weighted MR imaging of the liver: distinguishing hepatic abscess from cyctic or necrotic tumor. Abdominal Imaging 2001; 26:161-165.
  • Holzapfel K, Rummeny E, Gaa J. Diffusion-weighted MR imaging of hepatic abscesses: possibility of different apparent diffusion coefficient (ADC)-values in early and mature abscess formation. Abdominal Imaging 2007; 32:538-539.
  • Müller MF, Prasad P, Siewert B. Abdominal diffusion mapping with use of a whole-body echo-planar system. Radiology 1994;190:475-483. Pathology. 6th ed. W. B. Saunders Company;2005;19:607-643.
There are 16 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Ebru Yılmaz This is me

Ayhan Yılmaz This is me

Bülent Öner This is me

Publication Date January 1, 2013
Published in Issue Year 2013 Volume: 66 Issue: 1

Cite

APA Yılmaz, E., Yılmaz, A., & Öner, B. (2013). Karaciğer Kitlelerinin Benign-Malign Ayrımında Difüzyon Ağırlıklı Sekansın Önemi. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 66(1), 7-13. https://doi.org/10.1501/Tipfak_0000000834
AMA Yılmaz E, Yılmaz A, Öner B. Karaciğer Kitlelerinin Benign-Malign Ayrımında Difüzyon Ağırlıklı Sekansın Önemi. Ankara Üniversitesi Tıp Fakültesi Mecmuası. January 2013;66(1):7-13. doi:10.1501/Tipfak_0000000834
Chicago Yılmaz, Ebru, Ayhan Yılmaz, and Bülent Öner. “Karaciğer Kitlelerinin Benign-Malign Ayrımında Difüzyon Ağırlıklı Sekansın Önemi”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 66, no. 1 (January 2013): 7-13. https://doi.org/10.1501/Tipfak_0000000834.
EndNote Yılmaz E, Yılmaz A, Öner B (January 1, 2013) Karaciğer Kitlelerinin Benign-Malign Ayrımında Difüzyon Ağırlıklı Sekansın Önemi. Ankara Üniversitesi Tıp Fakültesi Mecmuası 66 1 7–13.
IEEE E. Yılmaz, A. Yılmaz, and B. Öner, “Karaciğer Kitlelerinin Benign-Malign Ayrımında Difüzyon Ağırlıklı Sekansın Önemi”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 66, no. 1, pp. 7–13, 2013, doi: 10.1501/Tipfak_0000000834.
ISNAD Yılmaz, Ebru et al. “Karaciğer Kitlelerinin Benign-Malign Ayrımında Difüzyon Ağırlıklı Sekansın Önemi”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 66/1 (January 2013), 7-13. https://doi.org/10.1501/Tipfak_0000000834.
JAMA Yılmaz E, Yılmaz A, Öner B. Karaciğer Kitlelerinin Benign-Malign Ayrımında Difüzyon Ağırlıklı Sekansın Önemi. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2013;66:7–13.
MLA Yılmaz, Ebru et al. “Karaciğer Kitlelerinin Benign-Malign Ayrımında Difüzyon Ağırlıklı Sekansın Önemi”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 66, no. 1, 2013, pp. 7-13, doi:10.1501/Tipfak_0000000834.
Vancouver Yılmaz E, Yılmaz A, Öner B. Karaciğer Kitlelerinin Benign-Malign Ayrımında Difüzyon Ağırlıklı Sekansın Önemi. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2013;66(1):7-13.