BibTex RIS Cite

Tonsil T4 Skuamöz Hücreli Karsinomu Nedeniyle Tedavi Gören Hastalarda Tedavi Sonuçları

Year 2012, Volume: 65 Issue: 3, 169 - 173, 01.03.2012

Ela Cömert Ümit Tunçel Caner Kılıç Buğra Cengiz Yıldız Güney Bektaș Kaya

https://doi.org/10.1501/Tipfak_0000000830

Abstract

Keywords

-

References

  • Fein DA, Lee WR, Amos WR et al. Oropharyngeal carcinoma treated with radiotherapy: a 30-year experience. Int J Radiat Oncol Biol Phys 1996;34:289- 296.
  • Mendenhall WM, Morris CG, Amdur RJ et al. Definitive radiotherapy for tonsillar squamous cell carcinoma. Am J Clin Oncol 2006;29:290-297.
  • Zelefsky MJ, Harrison LB, Fass DE et al. Post-operative radiotherapy for oral cavity cancers: impact of anatomic subsite on treatment outcome. Head Neck Surg 1990;12:470-475.
  • Zelefsky MJ, Harrison LB, Armstrong JG. Long-term treatment results of post-operative radiation therapy for advanced stage oropharyngeal carcinoma. Cancer 1992;70:2388-2395.
  • Shirazi HA, Sivaandan R, Goode Ret al. Advanced-staged tonsillar squamous carcinoma: organ preservation versus surgical management of the primary site. Head Neck 2006;28:587-594.
  • Wittekind C, Compton CC, Greene FL et al. TNM residual tumor classification revisited. Cancer 2002;94:2511-2516.
  • Perez CA, Patel MM, Chao KS et al. Carcinoma of the tonsillar fossa: prognostic factors and long-term therapy outcome. Int J Radiat Oncol Biol Phys 1998;42:1077-1084.
  • Hicks WL Jr, Kuriakose MA, Loree TR et al. Surgery versus radiation therapy as single-modality treatment of tonsillar fossa carcinoma: the Roswell Park Cancer Institute experience (1971- 1991). Laryngoscope 1998;108:1014- 1019.
  • Mizono GS, Diaz RF, Fu KK et al. Carcinoma of the tonsillar region. Laryngoscope 1986;96:240-244.
  • Parsons JT, Mendenhall WM, Million RR et al. The Management of Primary Cancers of the Oropharynx: Combined Treatment or Irradiation Alone? Semin Radiat Oncol 1992;2:142-148.
  • Poulsen M, Porceddu SV, Kingsley PA et al. Locally advanced tonsillar squamous cell carcinoma: Treatment approach revisited. Laryngoscope 2007;117:45-50.
  • Parsons JT, Mendenhall WM, Stringer SP et al. Squamous cell carcinoma of the oropharynx: surgery, radiation therapy, or both. Cancer 2002;94:2967- 2980.
  • Chang AR, Wu HG, Park CI et al. Retrospective analysis of the treatment results for patients with squamous cell carcinoma of tonsil. Cancer Res Treat 2005;37:92-97.
  • Zelefsky MJ, Gaynor J, Kraus D et al. Long-term subjective functional outcome of surgery plus postoperative radiotheraphy for advanced stage oral cavity and oropharyngeal carcinoma. Am J Surg. 1996;171:258-261.
  • Mendenhall WM, Amdur RJ, Stringer SP et al. Radiation therapy for squamous cell carcinoma of the tonsillar region: a preferred alternative to surgery? J Clin Oncol 2000;18:2219- 2225.
  • Röösli C, Tschudi DC, Studer G et al. Outcome of patients after treatment for a squamous cell carcinoma of the oropharynx. Laryngoscope 2009;119:534-540.
  • Machtay M, Rosenthal DI, Hershock D et al. Penn Cancer Center Clinical Trials Group. Organ preservation therapy using induction plus concurrent chemoradiation for advanced resectable oropharyngeal carcinoma: a University of Pennsylvania Phase II Trial. J Clin Oncol 2002;20:3964-3971.
  • Chen AY, Schrag N, Hao Y et al. Changes in treatment of advanced oropharyngeal cancer, 1985-2001. Laryngoscope 2007;117:16-21.

Tonsil T4 Skuamöz Hücreli Karsinomu Nedeniyle Tedavi Gören Hastalarda Tedavi Sonuçları

Year 2012, Volume: 65 Issue: 3, 169 - 173, 01.03.2012

Ela Cömert Ümit Tunçel Caner Kılıç Buğra Cengiz Yıldız Güney Bektaș Kaya

https://doi.org/10.1501/Tipfak_0000000830

Abstract

Amaç: Çalıșmanın amacı cerrahi ile beraber radyoterapi ve kemoterapi veya primer
radyoterapi ile beraber kemoterapi gören T4 tonsil karsinomlu olgularda tedavi sonuçlarının
karșılaștırılmasıdır.
Gereç ve Yöntem: T4a evreli, tonsil karsinomu nedeniyle küratif tedavi gören 21 hasta
çalıșmaya dahil edildi. Bu hastaların 9’una cerrahi ve adjuvan radyoterapi ve kemoterapi
uygulandı, 12’si primer radyoterapi ile kombine kemoterapi gördü.
Bulgular: Cerrahi sonrasında postoperatif radyoterapi ve kemoterapi gören ve primer
radyoterapi ile kombine kemoterapi gören hastaların lokoregional rekürrens oranları sırası ile
%77 ve %75 olarak saptandı. Kaplan-Meier sağkalım analizi kullanılarak cerrahi uygulanan
hastaların hastalık spesifik 2 ve 3 yıllık sağkalım oranları sırası ile %73 ve %45 olarak hesaplandı.
Primer radyoterapi ve kemoterapi gören hastaların 2 ve 3 yıllık hastalık spesifik sağkalım
oranları ise %67 ve %42 olarak saptandı.
Sonuç: İleri evre orofarenks tümörlerinde radikal cerrahi ve cerrahi sonrası radyoterapi ve
kemoterapi tedavisinin yerini yavaș yavaș primer radyoterapi ile kombine kemoterapi tedavisi
almaktadır. Bulgularımız T4 evreli tonsil tümörlerinde kliniğimizin mevcut yaklașımı olan
radikal cerrahi tedavinin yerini primer radyoterapi ile kombine kemoterapinin alabileceği
fikrini ortaya koymuștur.

Keywords

Total larenjektomi trakeoözefageal fistül ses rehabilitasyonu

References

  • Fein DA, Lee WR, Amos WR et al. Oropharyngeal carcinoma treated with radiotherapy: a 30-year experience. Int J Radiat Oncol Biol Phys 1996;34:289- 296.
  • Mendenhall WM, Morris CG, Amdur RJ et al. Definitive radiotherapy for tonsillar squamous cell carcinoma. Am J Clin Oncol 2006;29:290-297.
  • Zelefsky MJ, Harrison LB, Fass DE et al. Post-operative radiotherapy for oral cavity cancers: impact of anatomic subsite on treatment outcome. Head Neck Surg 1990;12:470-475.
  • Zelefsky MJ, Harrison LB, Armstrong JG. Long-term treatment results of post-operative radiation therapy for advanced stage oropharyngeal carcinoma. Cancer 1992;70:2388-2395.
  • Shirazi HA, Sivaandan R, Goode Ret al. Advanced-staged tonsillar squamous carcinoma: organ preservation versus surgical management of the primary site. Head Neck 2006;28:587-594.
  • Wittekind C, Compton CC, Greene FL et al. TNM residual tumor classification revisited. Cancer 2002;94:2511-2516.
  • Perez CA, Patel MM, Chao KS et al. Carcinoma of the tonsillar fossa: prognostic factors and long-term therapy outcome. Int J Radiat Oncol Biol Phys 1998;42:1077-1084.
  • Hicks WL Jr, Kuriakose MA, Loree TR et al. Surgery versus radiation therapy as single-modality treatment of tonsillar fossa carcinoma: the Roswell Park Cancer Institute experience (1971- 1991). Laryngoscope 1998;108:1014- 1019.
  • Mizono GS, Diaz RF, Fu KK et al. Carcinoma of the tonsillar region. Laryngoscope 1986;96:240-244.
  • Parsons JT, Mendenhall WM, Million RR et al. The Management of Primary Cancers of the Oropharynx: Combined Treatment or Irradiation Alone? Semin Radiat Oncol 1992;2:142-148.
  • Poulsen M, Porceddu SV, Kingsley PA et al. Locally advanced tonsillar squamous cell carcinoma: Treatment approach revisited. Laryngoscope 2007;117:45-50.
  • Parsons JT, Mendenhall WM, Stringer SP et al. Squamous cell carcinoma of the oropharynx: surgery, radiation therapy, or both. Cancer 2002;94:2967- 2980.
  • Chang AR, Wu HG, Park CI et al. Retrospective analysis of the treatment results for patients with squamous cell carcinoma of tonsil. Cancer Res Treat 2005;37:92-97.
  • Zelefsky MJ, Gaynor J, Kraus D et al. Long-term subjective functional outcome of surgery plus postoperative radiotheraphy for advanced stage oral cavity and oropharyngeal carcinoma. Am J Surg. 1996;171:258-261.
  • Mendenhall WM, Amdur RJ, Stringer SP et al. Radiation therapy for squamous cell carcinoma of the tonsillar region: a preferred alternative to surgery? J Clin Oncol 2000;18:2219- 2225.
  • Röösli C, Tschudi DC, Studer G et al. Outcome of patients after treatment for a squamous cell carcinoma of the oropharynx. Laryngoscope 2009;119:534-540.
  • Machtay M, Rosenthal DI, Hershock D et al. Penn Cancer Center Clinical Trials Group. Organ preservation therapy using induction plus concurrent chemoradiation for advanced resectable oropharyngeal carcinoma: a University of Pennsylvania Phase II Trial. J Clin Oncol 2002;20:3964-3971.
  • Chen AY, Schrag N, Hao Y et al. Changes in treatment of advanced oropharyngeal cancer, 1985-2001. Laryngoscope 2007;117:16-21.
There are 18 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Ela Cömert This is me

Ümit Tunçel This is me

Caner Kılıç This is me

Buğra Cengiz This is me

Yıldız Güney This is me

Bektaș Kaya This is me

Publication Date March 1, 2012
Published in Issue Year 2012 Volume: 65 Issue: 3

Cite

APA Cömert, E., Tunçel, Ü., Kılıç, C., Cengiz, B., et al. (2012). Tonsil T4 Skuamöz Hücreli Karsinomu Nedeniyle Tedavi Gören Hastalarda Tedavi Sonuçları. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 65(3), 169-173. https://doi.org/10.1501/Tipfak_0000000830
AMA Cömert E, Tunçel Ü, Kılıç C, Cengiz B, Güney Y, Kaya B. Tonsil T4 Skuamöz Hücreli Karsinomu Nedeniyle Tedavi Gören Hastalarda Tedavi Sonuçları. Ankara Üniversitesi Tıp Fakültesi Mecmuası. March 2012;65(3):169-173. doi:10.1501/Tipfak_0000000830
Chicago Cömert, Ela, Ümit Tunçel, Caner Kılıç, Buğra Cengiz, Yıldız Güney, and Bektaș Kaya. “Tonsil T4 Skuamöz Hücreli Karsinomu Nedeniyle Tedavi Gören Hastalarda Tedavi Sonuçları”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 65, no. 3 (March 2012): 169-73. https://doi.org/10.1501/Tipfak_0000000830.
EndNote Cömert E, Tunçel Ü, Kılıç C, Cengiz B, Güney Y, Kaya B (March 1, 2012) Tonsil T4 Skuamöz Hücreli Karsinomu Nedeniyle Tedavi Gören Hastalarda Tedavi Sonuçları. Ankara Üniversitesi Tıp Fakültesi Mecmuası 65 3 169–173.
IEEE E. Cömert, Ü. Tunçel, C. Kılıç, B. Cengiz, Y. Güney, and B. Kaya, “Tonsil T4 Skuamöz Hücreli Karsinomu Nedeniyle Tedavi Gören Hastalarda Tedavi Sonuçları”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 65, no. 3, pp. 169–173, 2012, doi: 10.1501/Tipfak_0000000830.
ISNAD Cömert, Ela et al. “Tonsil T4 Skuamöz Hücreli Karsinomu Nedeniyle Tedavi Gören Hastalarda Tedavi Sonuçları”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 65/3 (March 2012), 169-173. https://doi.org/10.1501/Tipfak_0000000830.
JAMA Cömert E, Tunçel Ü, Kılıç C, Cengiz B, Güney Y, Kaya B. Tonsil T4 Skuamöz Hücreli Karsinomu Nedeniyle Tedavi Gören Hastalarda Tedavi Sonuçları. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2012;65:169–173.
MLA Cömert, Ela et al. “Tonsil T4 Skuamöz Hücreli Karsinomu Nedeniyle Tedavi Gören Hastalarda Tedavi Sonuçları”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 65, no. 3, 2012, pp. 169-73, doi:10.1501/Tipfak_0000000830.
Vancouver Cömert E, Tunçel Ü, Kılıç C, Cengiz B, Güney Y, Kaya B. Tonsil T4 Skuamöz Hücreli Karsinomu Nedeniyle Tedavi Gören Hastalarda Tedavi Sonuçları. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2012;65(3):169-73.