Malign Plevral Efüzyonlarda Leptin: Yeni Bir Markır Olabilir mi?

Year 2011, Volume: 64 Issue: 3, 127 - 131, 01.03.2011

Serap Duru , Zeynep Sönmez - Saygıdeğer Alper Dilli Günnur Dikmen Özlem Sever Sadık Ardınç

https://doi.org/10.1501/Tipfak_0000000796

Abstract

Keywords

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Malign Plevral Efüzyonlarda Leptin: Yeni Bir Markır Olabilir mi?

Abstract

Amaç: Bazı malign ve benign hastalıklar plevral efüzyona yol açabilir. Bu çalışmada, malign ve malign olmayan plevral efüzyonlarda, serum ve plevral sıvıda leptin düzeyleri arasındaki farkı araştırmayı amaçladık.Yöntemler: Çalışmaya yaş ortalaması ve vücut kitle indeksi (VKI) benzer olan malign (n=20), malign olmayan plevral efüzyonlu (n=20) hastalar ve sigara içmeyen sağlıklı bireyler (n=20, kontrol grubu) alındı. Çalışmaya alınan 3 grupta serumda leptin, plevral efüzyonlu hasta gruplarında ise plevral sıvıda leptin düzeylerine bakıldı. Bulgular: Malign plevral efüzyonlu hasta grubunda hem kontrol hem de malign olmayan plevral efüzyonlu hasta grubuna göre serum ve plevral sıvı leptin düzeylerinin anlamlı olarak yüksek olduğu görüldü (p < 0.001). Kadın ve erkek hastalar arasında plevral sıvı leptin düzeyleri arasında farklılık bulunmazken (p=0.097), serum leptin düzeyinin kadın hastalarda daha yüksek (p < 0.001) olduğu görüldü.Sonuç: Serum ve plevral sıvı leptin düzeyinin artması, malign plevral efüzyonlarda leptinin kullanılabilir yeni bir markır olabileceğini göstermektedir.

Keywords

Leptin, malignite, plevral efüzyon

References

• Gürkök S, Genç O. Malignant pleural ef- fusion. Turkiye Klinikleri J Surg Med Sci 2006; 2: 37-41.
• Light RW. Pleural effusion. N Eng J Med 2002; 346: 1971-7.
• Yokoyama A, Maruyama M, Ito K. Inter- luekin 6 activity in pleural effusion. Chest 1992; 102: 1055-9.
• Kiropoulus TS, Kostikos K, Oikonomidi S. Acute phase markers for the differeantiation of infectious and malignant pleural effu- sions. Respir Med 2007; 101: 910-8.
• Bunatova K, Obermajer N, Kotyza J, at al. Levels of cathepsine S and H in pleural fluids of inflammatory and neoplastic origin. Int J Biol Markers 2009; 24:47-21.
• Iwagava K, Numata Y, Katsuura G. Structure- function studies of human leptin. J Biol- Chem, 1998; 273: 35245-9.
• Gong DW, Bi S, Pratley RE, Weintraub BD, at al. Genomic structure and promoter anal- ysis of the human obese gene. J BiolChem 1996; 271: 3971-4.
• Zhang Y, Proenca R, Maffei M, et al. Posi- tional cloning of the Mouse obese gene and its human homologue. Nature 1994: 372: 425-32.
• Pelleymounter MA, Cullen MJ, Baker MB, at al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995; 269: 540-3.
• Kamohara S, Burcelin R, Halaas JL., et al Acute stimülation of glucose metabolism in mice by leptin treatments. Nature 1997; 389 : 374-7.
• Ergün A. Adipose tissue and the adipocyte: review. Turkiye Klinikleri J Med Sci 2005; 25: 412-20.
• Ergün A. Leptin. Turkiye Klinikleri J Med Sci 1999; 19: 130-6.
• Emral R. Adiponectin and other cytokines: medical education. Turkiye Klinikleri J Med Sci 2006; 26: 409-20.
• Magni P, Vettor Pagano C, Calcagno A, et al. Expression of a leptin receptor in immor- talised gonadotropin-releasing hormone se- creting neurons. Endocrinology 1999; 140: 1581-5.
• Chehab FF, Lim ME, Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 1996; 12: 318-20.
• Bennet BD, Solar GP, Yuan JO, et al. A role for leptin and its cognate receptor in haema- topoiesis. Curr Biol 1996; 6: 1170-80 .
• Lord GM, Matarese G, Howard JK, et al. Leptin modulaters the T cell immune re- sponse and reverses starvation induced im- munosuppression. Nature 1998; 394: 897- 901.
• Bouloumie A, Dresler HCA, Lafontan M. Leptin, the product of the Ob gene promotes angiogenesis. Circ Res 1998; 83: 1059-66.
• Bado A, Levasseur S, Le Marchand-Brustel Y, et al. The Stomach is a source of leptin. Nature 1998; 394: 790-3.
• Iwaniec UT, Heaney RP, Cullen DM, et al. Leptin increases the number of mineralized bone nodules in vitro. J Bone Miner Res 1998; 13: 2-12.
• Hoggard N, Hunter L, Duncan JS, et al. Leptin and leptin receptor mRNA and pro- tein expression in the murine fetus and pl- ecenta. Proc Natl Acad Sci USA 1997; 94: 11073-8.
• Briscoe CP, Hanif S, Arch CR, et al. Leptin receptor long form signalling in a human liver cell line. Cytokine 2001; 14: 225-9.
• Ciof JA, Shaffer AW, Zupancic TJ. Novel B219/OB receptor isoforms: possible role of leptin in hematopoesis and repruduction. Not Med 1996; 2: 585-9.
• Glassow A, Haidan A, Hilbers U, et al. Ex- pression of Ob receptor in normal human adrenals: differantial regulation of adreno- cortical and adrenomeddullary function by leptin. J Clin Endocrinol Metab 1998; 83: 4459-66.
• Ishikawa M, Kitayama J, Nagawa H. Expres- sion pattern of leptin and leptin receptor (ob-r) in human gastric cancer. World J Gas- troenterol 2006; 12: 5517-22.
• Caldefie-Chezet F. Leptin: a proliferative fac- tor of breast cancer? Study on human duc- tal carcinoma. Biochemical and biophysical research comminications. Biochem Biophys Res Commun 2005; 334: 737-41.
• Terzidis A. Elevated serum leptin levels: a risk factor for non small cell lung cancer? Oncol- ogy 2009; 76: 19-25.
• Riberio R. A functional polymorphysm in the promoter region of leptin gene increases susceptibility for non small cell lung cancer. Eur J Cancer 2006; 42: 1188-93.
• Çelik G, Kaya A, Poyraz B. Diagnostic value of leptin in tuberculous pleural effusions. Int J Clin Pract 2006; 60: 1437-42.
• Prabha C, Supriya P, Das SD, et al. Leptin re- sponse in patients with tuberculous pleuritis. Indian J Med Res 2008; 128: 721-7.
• McConway MG, Johnson D, Kelly A, et al. Differences in circulating concentrations of total, free and bound leptin relate to gender and body composition in adult humans. Ann Clin Biochem 2000; 37: 717-23.