Yeni Bir Antibakteriyel Ajan: DAPTOMİSİN

Year 2010, Volume: 63 Issue: 3, 85 - 88, 01.03.2010

Gülden Yılmaz Bozkurt Hakan Kutlu Ayla Arslan Osman Memikoğlu

https://doi.org/10.1501/Tipfak_0000000767

Abstract

Keywords

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Yeni Bir Antibakteriyel Ajan: DAPTOMİSİN

Abstract

Dünya çapında artan antibiyotik direnci nedeniyle gram pozitif bakteri infeksiyonları, özellikle de Metisilin Dirençli S.aureus (MRSA), için yeni tedavi seçeneklerine ihtiyaç duyulmaktadır. Daptomisin ise geniş gram pozitif patojen etkinliğine sahip olan siklik lipopeptit sınıfı bir antimikrobiyaldir. Komplike deri ve yumuşak doku infeksiyonları, Staphylococcus aureus’un etken olduğu bakteriyemi ve sağ kalp infektif endokarditi için onay almıştır. Hızlı bakterisidal etkinliğinin yanında günde tek doz 4-6mg/kg infüzyon şeklinde uygulanmaktadır. Daptomisin ile kullanımda olan diğer geniş gram pozitif etkinliğe sahip olan 3 antibiyotiğin (vankomisin, linezolid, quinupristin-dalfopristin) minimum İnhibitör Konsantrasyonları (MİK) karşılaştırılmış, MİK50 ve MİK90 değerleri daptomisin, vankomisin, linezolid ve quinupristin-dalfopristin için sırasıyla; 0.125mg/L-0.25mg/L, 1mg/L- 1.5mg/L, 0.5mg/L-0.75mg/L ve 0.5mg/L-0.75mg/L olarak hesaplanmıştır. Diğer antibakteriyellere göre en düşük MIC değerine sahip olan daptomisin dirençli gram pozitif patojenlerin neden olduğu infeksiyonların tedavisinde bir terapötik seçenek olarak karşımıza çıkmaktadır

Keywords

Daptomisin, Lipopeptit, Gram Pozitif Bakteri, Staphylococcus Aureus

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