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Kronik Tekrarlayıcı Tonsillit-Adenotonsiller Hipertrofide Epstein Barr Virüs ve Herpes Simpleks Virüs Tip 1 Analizi* The Analysis Of Epstein Barr Virus And Herpes Simplex Virus Type 1 In Chronic Recur

Year 2007, Volume: 60 Issue: 4, 156 - 162, 01.04.2007

Reşit Doğan Köseoğlu Nurper Filiz İbrahim Aladağ Mehmet Güven Ahmet Eyibilen

https://doi.org/10.1501/Tipfak_0000000577

Abstract

Keywords

-

References

  • Endo LH, Vassallo J, Sakano E et al.Detection of Epstein-Barr virus and su- bsets of lymphoid cells in adenoid tissue of children under 2 years of age. Interna- tional Journal of Pediatric Otorhinolaryn- gology 2002; 66: 223-226.
  • Yamanaka N and Kataura A. Viral infection associated with recurrent tonsillitis. Acta Otolaryngol (Stockh) 1984; 416(Suppl.); 30-37.
  • Kunimoto M, Tamura S, Yoshie O et al. Epstein-Barr virus in Waldeyer’s lympha- tic tissue, Adv Otorhinolaryngol Basel, Karger 1992; 47: 151-160.
  • Yoda K, Aramaki H, Yamauchi Y et al. De- tection of herpes simplex and Epstein- Barr viruses in patient with acute tonsilli- tis. Abstracts III International Symposium on Tonsils June 21–23, Sapporo, Japan, 1995. p. 31.
  • Hirao M, Harabuchi Y, Kataura A et al. Im- munological role of human palatine ton- sil in Epstein-Barr virus persistence. Acta Otolaryngol (Stockh) 1996; 523(Suppl.): 158-160.
  • Endo LH, Ferreira D, Montenegro MCS et al. Detection of Epstein-Barr virus in ton- sillar tissue of children and the relations- hip with recurrent tonsillitis. Int J Pediatr Otorhinolaryngol 2001; 58:9-15.
  • Stewart JP and Arrand JR. Expression of the Epstein-Barr virus latent membrane protein in nasopharyngeal carcinoma bi- opsy specimens. Hum Pathol 1993; 24: 239–242.
  • Niedobitek G, Agathanggelou A, Herbst H et al. Epstein-Barr virus (EBV) infection in infectious mononucleosis: virus latency, replication and phenotype of EBV infec- ted cells. J Pathol 1997: 182; 151-159.
  • Smith RD. Epstein-Barr virus: a ubiqu- itous agent that can immortalize cells. Hum Pathol 1993; 24: 233-234.
  • Tanaka N. Infection of herpes simplex virus (HSV) and Epstein-Barr (EBV) in acute tonsillitis-histopathological assess- ment by optical and electron microscopic observtion of biopsy specimens of tonsils. Nippon Jibiinkoka Gakkai Kaiho 2001; 104: 1093-1102.
  • Kerr BM, Lear AL, Rowe M et al. Three transcriptionally distinct forms of Epste- in-Barr virus latency in somatic cell hyb- rids: cell phenotype dependence of virus promoter usage. Virology 1992; 187: 189- 201.
  • Ring CJA. The B cell-immortalizing fun- ctions of Epstein-Barr virus. J Gen Virol 1994; 75: 1-13.
  • Sadler RH and Raab-Traub N. Structural analyses of the Epstein-Barr virus Bam- HI A transcripts. J Virol 1995: 69; 1132- 1141.
  • Young LS, Lau R, Rowe M et al. Diaerenti- ation-associated expression of the Epste- in-Barr virus BZLF1 transactivator protein in oral hairy leukoplakia. J Virol 1991; 65: 2868-2874.
  • De Souza YG, Greenspan D, Felton JR et al. Localization of Epstein-Barr virus DNA in the epithelial cells of oral hairy leukop- lakia by in situ hybridization on tissue section. N Engl J Med.1989; 320: 1559- 1560.
  • Prang NS, Hornef MW, Jager M et al. Ly- tic replication of Epstein-Barr virus in the peripheral blood: analysis of viral gene expression in B lymphocytes during infe- ctious mononucleosis and in the carrier state. Blood 1997; 89: 1665-1677.
  • Perez AF, Mari JMN, Garcia JMA et al. Role of viral reactivation in recurrent adenoidi- tis and tonsillitis in children. Acta Otorri- nolaringol Espanhola 1989; 40: 277-278.
  • Lones MA, Mishalany S, Shintaku IP et al. Changes in tonsils and adenoids in child- ren with posttransplant lymphoprolifera- tive disorder: report of three cases with early envolvement of Waldeyer’s ring. Hum Pathol 1995; 26: 525–530.
  • Takimoto T, Tanaka S, Ishikawa S et al.The human nasopharynx as a reservoir for Epstein-Barr virus. Auris Nasus Larynx 1989; 16: 109-115.
  • Zhang HY, Qu G, Deng ZW et al. Epstein- Barr virus DNA in nasopharyngeal biopsi- es. Virus Res 1989; 12: 53-59.
  • You S, Yao K, Cao Y. Latency of Epstein- Barr virus and its relationship to nasop- haryngeal carcinomas. Chung Hua Chung Liu Tsa Chih 1996; 18: 23-26.
  • Zeidler R, Meissner P, Eissner G et al. Ra- pid proliferation of B cells from adenoids in response to Epstein-Barr virus infecti- on. Cancer Res 1996; 56: 5610-5614.
  • Babcock GJ, Decker LL, Volk M et al. EBV persistence in memory B cells in vivo. Im- munity 1998; 9: 395-404.
  • Kobayashi R, Takeuchi H, Sasaki M et al. Detection of Epstein-Barr virus infection in the epithelial cells and lymphocytes of non-neoplastic tonsils by in situ hybridi- zation and in situ PCR. Arch Virol 1998; 143: 803-813.
  • Endo LH, Rezende D, Pinto GA et al. Pro- ceedings of the Seventh International Congress of Pediatric Otorhino-laringo- logy, June 7-10, 1998, Helsinki, Finland. Detection of Epstein-Barr virus on pala- tine tonsil and the relationship to recur- rent tonsillitis. Adv.Ped. Otorhinolaryn- gol. (1998) CD ROM.
  • Niedobitek G, Herbst H, Young LS et al. Patterns of Epstein-Barr virus infection in non-neoplastic lymphoid tissue. Blood 1992; 79: 2520–2526.
  • Chen CL, Hsu MM, Hsu HC. Differential expression of EBER1 in non tumor na- sopharyngeal carcinoma. Intervirology 1996; 39: 230-235.
  • Pinto GA and Irazusta SP. EBV-Virus do Epstein-Barr Cap (9) In: Manual de Imu- nohistoquimica, Sociedade Brasileira de Patologia, Sao Paulo; 1995. p. 58–61.

Kronik Tekrarlayıcı Tonsillit-Adenotonsiller Hipertrofide Epstein Barr Virüs ve Herpes Simpleks Virüs Tip 1 Analizi

Year 2007, Volume: 60 Issue: 4, 156 - 162, 01.04.2007

Reşit Doğan Köseoğlu Nurper Filiz İbrahim Aladağ Mehmet Güven Ahmet Eyibilen

https://doi.org/10.1501/Tipfak_0000000577

Abstract

Amaç: Bu çalışmada amacımız, kronik tekrarlayıcı tonsillit/adenotonsiller hipertrofi (KTT/ATH) olgularının patogenezinde, Epstein Barr virüs (EBV) ve Herpes simpleks tip 1 virüsünün (HSV tip 1) rolünü immünohistokimyasal (İHK) ve in situ hibridizasyon (İSH) yöntemleri ile araştırmaktır. Gereç ve Yöntem: Çalışmaya toplam 50 KTT/ATH olgusunun adenotonsillektomi materyali dahil edildi. Parafin kesitlerde İHK yolla EBV LMP, EBNA-2, EBV early Ag, HSV tip-1, CD3, CD10, CD20, CD21 ve CD56 antikorları ile İSH yoluyla EBV için DNA-DNA hibridizasyonu uygulandı. Bulgular: Olguların yaşları 4 ile 32 arasındaydı. Olguların 32’si kadın, 18’i erkekti. Toplam 8 olguda (%16) EBV genomu saptanırken, HSV hiç bir olguda tespit edilmedi. EBV genomu saptanan olguların tamamında ekstrafolliküler lenfoid hücrelerde pozitiflik görüldü. Sadece 2 olguda ilaveten anti-EBV early antijen ile skuamöz hücrelerde de pozitiflik saptandı. İSH yöntemi ile sadece 4 olgu (%8) EBV genomu için pozitifti. EBV genomu pozitif lenfoid hücrelerinin tamamı CD20 (+) B-lenfosit fenotipine sahipti. Sonuç: Çalışmamızda EBV genomu pozitif olguların oranı (%16), literatürde rapor edilen sınırlar içerisindeydi. İSH’ de saptanan pozitiflik oranının düşüklüğü (%8) işlemin uygulanmasındaki hassasiyet gerektiren sıcaklık ve nem gibi faktörlerden kaynaklanmış olabilir. EBV genomu saptanan lenfoid hücrelerin tiplendirmesi ve lokalizasyonu literatür verileri ile uyumluydu. Literatürde daha çok EBV’ nin KTT/ATH ile olası ilişkisi üzerine yayınlar mevcuttur. Bu çalışmalardan anlamlı olabilecek sonuçlar elde edilmiş olmakla birlikte daha geniş seriler üzerinde yapılmış çalışmaların sonuçlarına ihtiyaç olduğu anlaşılmaktadır. HSV ile KTT/ATH arasındaki ilişkiyi araştıran makale sayısı son derece sınırlı olup olası bir ilişkiden söz etmek mümkün görünmemektedir

Keywords

kronik tekrarlayıcı tonsillitis adenotonsiller hipertrofi EBV HSV Tip I

References

  • Endo LH, Vassallo J, Sakano E et al.Detection of Epstein-Barr virus and su- bsets of lymphoid cells in adenoid tissue of children under 2 years of age. Interna- tional Journal of Pediatric Otorhinolaryn- gology 2002; 66: 223-226.
  • Yamanaka N and Kataura A. Viral infection associated with recurrent tonsillitis. Acta Otolaryngol (Stockh) 1984; 416(Suppl.); 30-37.
  • Kunimoto M, Tamura S, Yoshie O et al. Epstein-Barr virus in Waldeyer’s lympha- tic tissue, Adv Otorhinolaryngol Basel, Karger 1992; 47: 151-160.
  • Yoda K, Aramaki H, Yamauchi Y et al. De- tection of herpes simplex and Epstein- Barr viruses in patient with acute tonsilli- tis. Abstracts III International Symposium on Tonsils June 21–23, Sapporo, Japan, 1995. p. 31.
  • Hirao M, Harabuchi Y, Kataura A et al. Im- munological role of human palatine ton- sil in Epstein-Barr virus persistence. Acta Otolaryngol (Stockh) 1996; 523(Suppl.): 158-160.
  • Endo LH, Ferreira D, Montenegro MCS et al. Detection of Epstein-Barr virus in ton- sillar tissue of children and the relations- hip with recurrent tonsillitis. Int J Pediatr Otorhinolaryngol 2001; 58:9-15.
  • Stewart JP and Arrand JR. Expression of the Epstein-Barr virus latent membrane protein in nasopharyngeal carcinoma bi- opsy specimens. Hum Pathol 1993; 24: 239–242.
  • Niedobitek G, Agathanggelou A, Herbst H et al. Epstein-Barr virus (EBV) infection in infectious mononucleosis: virus latency, replication and phenotype of EBV infec- ted cells. J Pathol 1997: 182; 151-159.
  • Smith RD. Epstein-Barr virus: a ubiqu- itous agent that can immortalize cells. Hum Pathol 1993; 24: 233-234.
  • Tanaka N. Infection of herpes simplex virus (HSV) and Epstein-Barr (EBV) in acute tonsillitis-histopathological assess- ment by optical and electron microscopic observtion of biopsy specimens of tonsils. Nippon Jibiinkoka Gakkai Kaiho 2001; 104: 1093-1102.
  • Kerr BM, Lear AL, Rowe M et al. Three transcriptionally distinct forms of Epste- in-Barr virus latency in somatic cell hyb- rids: cell phenotype dependence of virus promoter usage. Virology 1992; 187: 189- 201.
  • Ring CJA. The B cell-immortalizing fun- ctions of Epstein-Barr virus. J Gen Virol 1994; 75: 1-13.
  • Sadler RH and Raab-Traub N. Structural analyses of the Epstein-Barr virus Bam- HI A transcripts. J Virol 1995: 69; 1132- 1141.
  • Young LS, Lau R, Rowe M et al. Diaerenti- ation-associated expression of the Epste- in-Barr virus BZLF1 transactivator protein in oral hairy leukoplakia. J Virol 1991; 65: 2868-2874.
  • De Souza YG, Greenspan D, Felton JR et al. Localization of Epstein-Barr virus DNA in the epithelial cells of oral hairy leukop- lakia by in situ hybridization on tissue section. N Engl J Med.1989; 320: 1559- 1560.
  • Prang NS, Hornef MW, Jager M et al. Ly- tic replication of Epstein-Barr virus in the peripheral blood: analysis of viral gene expression in B lymphocytes during infe- ctious mononucleosis and in the carrier state. Blood 1997; 89: 1665-1677.
  • Perez AF, Mari JMN, Garcia JMA et al. Role of viral reactivation in recurrent adenoidi- tis and tonsillitis in children. Acta Otorri- nolaringol Espanhola 1989; 40: 277-278.
  • Lones MA, Mishalany S, Shintaku IP et al. Changes in tonsils and adenoids in child- ren with posttransplant lymphoprolifera- tive disorder: report of three cases with early envolvement of Waldeyer’s ring. Hum Pathol 1995; 26: 525–530.
  • Takimoto T, Tanaka S, Ishikawa S et al.The human nasopharynx as a reservoir for Epstein-Barr virus. Auris Nasus Larynx 1989; 16: 109-115.
  • Zhang HY, Qu G, Deng ZW et al. Epstein- Barr virus DNA in nasopharyngeal biopsi- es. Virus Res 1989; 12: 53-59.
  • You S, Yao K, Cao Y. Latency of Epstein- Barr virus and its relationship to nasop- haryngeal carcinomas. Chung Hua Chung Liu Tsa Chih 1996; 18: 23-26.
  • Zeidler R, Meissner P, Eissner G et al. Ra- pid proliferation of B cells from adenoids in response to Epstein-Barr virus infecti- on. Cancer Res 1996; 56: 5610-5614.
  • Babcock GJ, Decker LL, Volk M et al. EBV persistence in memory B cells in vivo. Im- munity 1998; 9: 395-404.
  • Kobayashi R, Takeuchi H, Sasaki M et al. Detection of Epstein-Barr virus infection in the epithelial cells and lymphocytes of non-neoplastic tonsils by in situ hybridi- zation and in situ PCR. Arch Virol 1998; 143: 803-813.
  • Endo LH, Rezende D, Pinto GA et al. Pro- ceedings of the Seventh International Congress of Pediatric Otorhino-laringo- logy, June 7-10, 1998, Helsinki, Finland. Detection of Epstein-Barr virus on pala- tine tonsil and the relationship to recur- rent tonsillitis. Adv.Ped. Otorhinolaryn- gol. (1998) CD ROM.
  • Niedobitek G, Herbst H, Young LS et al. Patterns of Epstein-Barr virus infection in non-neoplastic lymphoid tissue. Blood 1992; 79: 2520–2526.
  • Chen CL, Hsu MM, Hsu HC. Differential expression of EBER1 in non tumor na- sopharyngeal carcinoma. Intervirology 1996; 39: 230-235.
  • Pinto GA and Irazusta SP. EBV-Virus do Epstein-Barr Cap (9) In: Manual de Imu- nohistoquimica, Sociedade Brasileira de Patologia, Sao Paulo; 1995. p. 58–61.
There are 28 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Reşit Doğan Köseoğlu This is me

Nurper Filiz This is me

İbrahim Aladağ This is me

Mehmet Güven This is me

Ahmet Eyibilen This is me

Publication Date April 1, 2007
Published in Issue Year 2007 Volume: 60 Issue: 4

Cite

APA Köseoğlu, R. D., Filiz, N., Aladağ, İ., Güven, M., et al. (2007). Kronik Tekrarlayıcı Tonsillit-Adenotonsiller Hipertrofide Epstein Barr Virüs ve Herpes Simpleks Virüs Tip 1 Analizi. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 60(4), 156-162. https://doi.org/10.1501/Tipfak_0000000577
AMA Köseoğlu RD, Filiz N, Aladağ İ, Güven M, Eyibilen A. Kronik Tekrarlayıcı Tonsillit-Adenotonsiller Hipertrofide Epstein Barr Virüs ve Herpes Simpleks Virüs Tip 1 Analizi. Ankara Üniversitesi Tıp Fakültesi Mecmuası. April 2007;60(4):156-162. doi:10.1501/Tipfak_0000000577
Chicago Köseoğlu, Reşit Doğan, Nurper Filiz, İbrahim Aladağ, Mehmet Güven, and Ahmet Eyibilen. “Kronik Tekrarlayıcı Tonsillit-Adenotonsiller Hipertrofide Epstein Barr Virüs Ve Herpes Simpleks Virüs Tip 1 Analizi”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 60, no. 4 (April 2007): 156-62. https://doi.org/10.1501/Tipfak_0000000577.
EndNote Köseoğlu RD, Filiz N, Aladağ İ, Güven M, Eyibilen A (April 1, 2007) Kronik Tekrarlayıcı Tonsillit-Adenotonsiller Hipertrofide Epstein Barr Virüs ve Herpes Simpleks Virüs Tip 1 Analizi. Ankara Üniversitesi Tıp Fakültesi Mecmuası 60 4 156–162.
IEEE R. D. Köseoğlu, N. Filiz, İ. Aladağ, M. Güven, and A. Eyibilen, “Kronik Tekrarlayıcı Tonsillit-Adenotonsiller Hipertrofide Epstein Barr Virüs ve Herpes Simpleks Virüs Tip 1 Analizi”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 60, no. 4, pp. 156–162, 2007, doi: 10.1501/Tipfak_0000000577.
ISNAD Köseoğlu, Reşit Doğan et al. “Kronik Tekrarlayıcı Tonsillit-Adenotonsiller Hipertrofide Epstein Barr Virüs Ve Herpes Simpleks Virüs Tip 1 Analizi”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 60/4 (April 2007), 156-162. https://doi.org/10.1501/Tipfak_0000000577.
JAMA Köseoğlu RD, Filiz N, Aladağ İ, Güven M, Eyibilen A. Kronik Tekrarlayıcı Tonsillit-Adenotonsiller Hipertrofide Epstein Barr Virüs ve Herpes Simpleks Virüs Tip 1 Analizi. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2007;60:156–162.
MLA Köseoğlu, Reşit Doğan et al. “Kronik Tekrarlayıcı Tonsillit-Adenotonsiller Hipertrofide Epstein Barr Virüs Ve Herpes Simpleks Virüs Tip 1 Analizi”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 60, no. 4, 2007, pp. 156-62, doi:10.1501/Tipfak_0000000577.
Vancouver Köseoğlu RD, Filiz N, Aladağ İ, Güven M, Eyibilen A. Kronik Tekrarlayıcı Tonsillit-Adenotonsiller Hipertrofide Epstein Barr Virüs ve Herpes Simpleks Virüs Tip 1 Analizi. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2007;60(4):156-62.