Psödoeksfolyasyonlu Türk hastalarda HLA Class I antijenleri HLA Class I antigens in Turkish patients with pseudoexfoliation

Year 2005, Volume: 58 Issue: 2, 81 - 84, 01.02.2005

M. Erol Turaçlı Oya Kurnaz Tekeli Filiz Avşin Özdemir Hüseyin Tutkak

https://doi.org/10.1501/Tipfak_0000000146

Abstract

Keywords

-

Psödoeksfolyasyonlu Türk hastalarda HLA Class I antijenleri

Abstract

Amaç: Türk popülasyonunda psödoeksfolyasyon ile human leucocyte antigens (HLA) class I antijenleri arasındaki korelasyonu saptamak. Gereç ve Yöntem: En az bir gözünde psödoeksfolyasyonu olan 76 hasta ile psödoeksfolyasyonu olmayan 100 olguda HLA class I antijenleri incelendi. Bulgular: Psödoeksfolyasyon grubunda HLA A68, B39, CW4 istatistiksel olarak daha sık saptanırken HLA A1, B7 istatistiksel olarak daha az sıklıkta bulundu. Psödoeksfolyasyon ve kontrol grubunda haplotip frekansı açısından istatistiksel olarak belirgin bir fark saptanmadı. Sonuç: Farklı populasyonlar ve hasta akrabalarında yapılacak yeni çalışmalar psödoeksfolyasyon ile HLA arasındaki ilişkinin belirlenmesinde yardımcı olacaktır

Keywords

Psödoeksfolyasyon, glokom, HLA Class I antijenleri

References

• Streeten BW. Aberrant synthesis and aggregation of elastic tissue components in pseudoexfoliation Şbrillopathy: a unifying concept. New Trends Ophthalmol 1993; 8:187-196.
• Schlötzer-Schrehardt U, von der Mark K, Sakai LY et al. Increased extracellular deposition of Şbrillin-containing Şbrils in pseudoexfoliation syndrome. Invest Ophthalmol Vis Sci 1997; 38:970-984.
• Ritch R, Schlötzer-Schrehardt U. Exfoliation syndrome. Surv Ophthalmol 2001; 45:265-315.
• Schlötzer-Schrehardt U, Körtje KH, Erb C. Energy-Şltering transmission electron microscopy (EFTEM) in the elemental analysis of peudoexfoliative material. Current Eye Research 2001; 22:154-162
• Mitchell P, Wang JJ, Smith W. Association of pseudoexfoliation syndrome with increased vascular risk. Am J Ophthalmol 1997; 124:685-687.
• Taylor HR. Pseudoexfoliation, an environmental disease? Trans Ophthal Soc UK 1979; 99:302.
• Aasved H: Study of relatives of persons with Şbrillopathia epitheliocapsularis (pseudoexfoliation of the lens capsule). Acta Ophthalmol (Copenh) 1975; 53:879-86
• Terasaki PI, McClelland JD, Park MS et al. Microdroplet lymphocyte cytotoxicity test. In: Publications DHEW (NIH). Manual of Tissue Typing Techniques. Washington DC. US Government Printing Office 1973; 54:74-545.
• Forsius H. Exfoliation syndrome in various ethnic populations. Acta Ophthalmol (Suppl) 1988; 184:71-85.
• Sarfarazi M, Stoilov I. Genetics in glaucoma. In: Joseph W. Sassani, editor. Ophthalmic Fundementals Glaucoma.1999; Chapter 2: 15-31
• Olivius E, Polland W: Histocompatibility (HLA) antigens in capsuler glaucoma and simplex glaucoma, Acta Ophthalmol (Copenh) 1980; 58:406.
• Eustace P, Dwyer –Joyce P, McAuliffe-Curtin et al. HLA antigens in the pseudoexfoliation syndrome. Trans Ophthal Soc UK 1980; 100:510.
• FitzSimon JS, Mulvihill A, Kennedy S et al. Association of HLA type with pseudoexfoliation of the lens capsule. Br J Ophthalmol 1996; 80:402-404.
• Tokgöz G, Düzgün N, Turgay M et al. The distribution of HLA-A, B and C antigens in Turkish population. Turk J Med Res 1993; 11(1): 32-36.
• Joint Reports. In: Albert ED, et al, eds. Histocompatibility testing. Munksgaard: Cophenhagen, 1984; 118-209.
• Bodmer W, Thomson G. Population genetics and evaluation of the HLA system. In: Dausset J, Svejgaard A, eds. HLA and disease. Munksgaard: Cophenhagen, 1977; 280-92.