Behçet Hastaları’nda COVID-19 Aşılaması ve Hastalık Geçirme Durumunun İncelenmesi

Year 2023, Volume: 76 Issue: 3, 206 - 212, 24.10.2023

Recep Yılmaz

Abstract

Amaç: Behçet hastalığı deri, mukoza, eklem ve göz başta olmak üzere birçok sistemi tutabilen, nedeni bilinmeyen bir vaskülittir. Bu çalışmada Behçet hastalarında koronavirüs hastalığı-2019 (COVID-19) ve aşılama durumu incelendi. Behçet hastalarına ait özelliklerin, COVID-19 ile ilgili verilerle olan ilişkisi sorgulandı.

Gereç ve Yöntem: Bu çalışmaya 303 Behçet hastası rastgele bir şekilde dahil edildi. Hastaların aşılanma durumu ve yapılan COVID-19 aşısının türü sorgulandı. COVID-19 geçirip geçirmediği ve hastalığın nasıl seyrettiği incelendi. COVID-19 polimeraz zincir reaksiyonu (PCR) testi pozitif olan Behçet hastaları, hastalığı geçirmiş olarak kabul edildi.

Bulgular: Behçet hastalarının %40,6’sı erkek, yaş ortalaması 46,3 (±12,3), hastalık tanı yaşı 30,4 (±9,1) yıl olarak saptandı. Hastaların 132’sinde (%43,5) COVID-19 PCR testi pozitifliği tespit edildi. Test pozitifliği olan hastaların %72’sinin (n=95) semptomatik seyrettiği ve hastaneye yatış oranının %3 olduğu görüldü. COVID-19 geçiren Behçet hastalarında, geçirmeyenlere göre daha az oranda santral sinir sistemi tutulumu olduğu görüldü (p=0,01) Behçet hastalığının diğer klinik tutulumları, yaş, cinsiyet ve hastalık tanı yaşı ile COVID-19 geçirme öyküsü arasında anlamlı ilişki saptanmadı. Behçet hastalarında COVID-19 aşılamasında 1. doz aşı oranı %92,1, 2. doz için %89,4, 3. doz için %60 saptandı. Biontech aşısının diğer aşı türlerine göre daha sık oranda yapıldığı görüldü. COVID-19 aşılama sayısının, COVID-19 geçirmeyen grupta anlamlı olarak daha fazla olduğu tespit edildi (p=0,003).

Sonuç: Bu çalışmada Behçet hastalarında COVID-19 hastalığı oranı yüksek olsa da hastaneye yatış oranı düşük görüldü. COVID-19 aşılamasının önemi vurgulandı.

Anahtar Kelimeler: Behçet Hastalığı, Vaskülit, COVID-19, Aşılama

Keywords

Behçet Hastalığı, Vaskülit, COVID-19, Aşılama

Ethical Statement

Fakültesi, İnsan Araştırmaları Etik Kurulu tarafından onaylandı (karar no: İ08-514-22, tarih: 14.09.2022). Hasta Onayı: Hastalardan bilgilendirilmiş gönüllü onam alındı. Hakem Değerlendirmesi: Editörler kurulunun içinden ve dışından olan kişiler tarafından değerlendirilmiştir

Supporting Institution

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Project Number

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Thanks

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Investigation of COVID-19 Vaccination and Disease Status in Behçet’s Patients

Abstract

Objectives: Behçet’s disease is a vasculitis of unknown cause that can affect many systems, especially the skin, mucosa, joint and eyes. In this study, coronavirus disease-2019 (COVID-19) and vaccination status in Behçet’s patients were examined. The relationship between the characteristics of Behçet’s patients and the data related to COVID-19 was investigated.

Materials and Methods: Three hundred and three Behçet’s patients were randomly included in this study. The vaccination status of the patients and the type of COVID-19 vaccine administered were questioned. Whether the patients had COVID-19 and the disease process were examined. Behçet’s patients with a positive COVID-19 polymerase chain reaction (PCR) test were considered to have had the disease.

Results: The mean age was 46.3 (±12.3) years, 40.6% were male, and the age at diagnosis was 30.4 (±9.1) years. COVID-19 PCR test positivity was detected in 132 (43.5%) of the patients. It was observed that 72% (n=95) of the patients with test positivity were symptomatic and the hospitalization rate was 3%. It was observed that Behçet’s patients who had COVID-19 had less central nervous system involvement than those who did not (p=0.01). No significant correlation was found between other clinical manifestations of Behçet’s disease, age, gender, and the age at diagnosis of the disease, and the history of having COVID-19. The rate of COVID-19 vaccination in Behçet’s patients was 92.1% for the first dose, 89.4% for the second dose, and 60% for the third dose. It was observed that the Biontech vaccine was administered more frequently than other types of vaccines. It was detected that the number of COVID-19 vaccinations was significantly higher in the group that did not have COVID-19
(p=0.003).

Conclusion: In this study, although the rate of COVID-19 disease was high in Behçet’s patients, the rate of hospitalization was low. The importance of COVID-19 vaccination was emphasized.

Key Words: Behçet’s Disease, Vasculitis, COVID-19, Vaccination

Keywords

Behçet’s Disease, Vasculitis, COVID-19, Vaccination

Ethical Statement

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Supporting Institution

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Project Number

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Thanks

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