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Protective Measures Against Infection During Construction in Hematology Patients

Year 2016, Volume: 69 Issue: 3, 167 - 171, 21.12.2016

Abstract

Aim: Construction periods have an increased risk for invasive fungal infections in immunosuppressive hematology patients. We share our experience during a construction period in this article.

Material and Method: We summarize what we had performed to prevent infections in hematology patientsdue to the construction next to our department building in our hospital and the results.

Results: The most important issues in this setting are physical isolation of the hospital building and the patients treated in hematology and stem cell transplantation unit. Antifungal prophylaxis is also beneficial as an additional precaution in high risk patients.

Conclusion: Risk based multidisciplinary approach seems to be effective in these patients and infection control team play a critical role.

Supporting Institution

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Project Number

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References

  • 1. Clair JD, Colatrella S. Opening Pandora's (tool) Box: health care construction and associated risk for nosocomial infection. Infect Disord Drug Targets. 2013;13:177-183.
  • 2. Loo VG, Bertrand C, Dixon C, et al. Control of construction-associated nosocomial aspergillosis in an antiquated hematology unit. Infect Control Hosp Epidemiol.1996;17:360-364.
  • 3. Haiduven D. Nosocomial aspergillosis and building construction. Med Mycol. 2009;47 Suppl 1:S210-216
  • 4. Garnaud C, Brenier-Pinchart MP, Thiebaut-Bertrand A, ve ark. Seven-year surveillance of nosocomial invasive aspergillosis in a French University Hospital. J Infect. 2012;65:559-567.
  • 5. Berger J, Willinger B, Diab-Elschahawi M, et al. Effectiveness of preventive measures for hemato-oncologic patients undergoing stem cell transplantation during a period of hospital construction. Am J Infect Control. 2011;39:746-751.
  • 6. Etancelin P, Silly S, Merle V, et al. Efficacy of a multidisciplinary team for preventing hospital-acquired invasive aspergillosis: five years' experience. Pathol Biol (Paris). 2009;57:71-75.
  • 7. Klingspor L, Saaedi B, Ljungman P, Szakos A. Epidemiology and outcomes of patients with invasive mould infections: a retrospective observational study from a single centre (2005-2009).Mycoses.2015; 58:470-477.
  • 8. Neofytos D, Treadway S, Ostrander D, et al. Epidemiology, outcomes, and mortality predictors of invasive mold infections among transplant recipients: a 10-year, single-center experience. Transpl Infect Dis. 2013;15:233-242.
  • 9. Pagano L, Caira M, Nosari A, et al. Fungal infections in recipients of hematopoietic stem cell transplants: results of the SEIFEM B-2004 study--Sorveglianza Epidemiologica Infezioni Fungine Nelle Emopatie Maligne. Clin Infect Dis. 2007;45:1161-1170.
  • 10. Bassetti M, Righi E. Overview of Fungal Infections--The Italian Experience. Semin Respir Crit Care Med. 2015;36:796-805.
  • 11. Özen M, Yılmaz G, Coşkun B, ve ark. İnşaat sırasında meydana gelebilecek hematolojik enfeksiyonların engellenmesi. In: İnfeksiyon dünyası çalıştayı (20-23 Mart 2014, Ankara) Kitabı. 2014: 21.
  • 12. HolýO, Matoušková I. The importance of cleanrooms for the treatment of haematooncological patients. Wspolczesna Onkol 2012;16: 266–272.
  • 13. Özen M, Yılmaz G, Coşkun B, ve ark. A quasi-experimental study analyzing the effectiveness of portable high efficiency particulate absorption filters in preventing infections in hematology patients during construction. Turk J Hematol 2016;33:41-47
  • 14. Yılmaz Bozkurt G, Civriz Bozdag S, Topcuoglu P, ve ark. Invasive fungal infections during a construction period. Bone Marrow Transplantation. 2011; 46(Suppl. 1): 232.
  • 15. Koehler P, Cornely OA. Contemporary Strategies in the Prevention and Management of Fungal Infections. Infect Dis Clin North Am. 2015 Dec 28. pii: S0891-5520(15)00092-6.
  • 16. Ruhnke M, Arnold R, Gastmeier P. Infection control issues in patients with haematological malignancies in the era of multidrug-resistant bacteria. Lancet Oncol.2014 Dec;15(13):e606-19.
  • 17. Alothman A. Infection control and the immunocompromised host. Saudi J Kidney Dis Transpl. 2005;16:547-555.
  • 18. Simon A, Fleischhack G. Non-pharmacologic strategies to prevent and control infectious complications in pediatric hematology/oncology patients. Klin Padiatr. 2001 Sep;213 Suppl 1:A9-A21.
  • 19. Godbole G, Gant V. Respiratory tract infections in the immunocompromised.Curr Opin Pulm Med. 2013;19:244-250.
  • 20. Risi GF, Tomascak V. Prevention of infection in the immunocompromised host, Am J Infect Control 1998;26:594-606.
  • 21. Garner JS. Guideline for isolation precaution in hospitals. The Hospital Infection Control Practices Advisory Committee. Infect Control Hosp Epidemiol 1996;17:53-80.
  • 22. Oren I, Haddad N, Finkelstein R, Rowe JM. Invasive pulmonary aspergillosis in neutropenic patients during hospital construction: before and after chemoprophylaxis and institution of HEPA filters. Am J Hematol. 2001;66:257-262.
  • 23. Menegueti MG, Ferreira LR, Silva MF, et al. Assessment of microbiological air quality in hemato-oncology units and its relationship with the occurrence of invasive fungal infections: an integrative review. Rev Soc Bras Med Trop. 2013;46:391-396.
  • 24. Chang CC, Ananda-Rajah M, Belcastro A, et al. Consensus guidelines for implementation of quality processes to prevent invasive fungal disease and enhancedsurveillance measures during hospital building works, 2014. Intern Med J. 2014 Dec;44(12b):1389-1397.
  • 25. Akan H, Antia VP, Kouba M, et al. Preventing invasive fungal disease in patients with haematological malignancies and the recipients of haematopoietic stem cell transplantation: practical aspects. J Antimicrob Chemother. 2013 Nov; 68 Suppl 3:iii5-16.
  • 26. Kung HC, Johnson MD, Drew RH, et al.Clinical effectiveness of posaconazole versus fluconazole as antifungal prophylaxis in hematology-oncology patients: a retrospective cohort study. Cancer Med. 2014;3:667-673.
  • 27. Metan G, Türe Z, Pala Ç, et al. A Single Center Experience for Antifungal Prophylaxis in Patients with Acute Myelogenous Leukemia. Indian J Hematol Blood Transfus. 2015;31:339-345.
  • 28. Kidd F, Buttner C, Kressel AB. Construction: a model program for infection control compliance. Am J Infect Control. 2007;35:347-350.
  • 29. Centers for Disease Control and Prevention; Infectious Disease Society of America; American Society of Blood and Marrow Transplantation. Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. MMWR Recomm Rep. 2000 Oct;49(RR-10):1-125, CE1-7.
  • 30. Tomblyn M, Chiller T, Einsele H, et al.Center for International Blood and Marrow Transplant Research (CIBMTR); National Marrow Donor Program (NMDP); European Blood and Marrow Transplant Group (EBMT); American Society of Blood and Marrow Transplantation (ASBMT); Canadian Blood and Marrow Transplant Group (CBMTG); Infectious Disease Society of America (IDSA); Society for Healthcare Epidemiology of America (SHEA); Association of Medical Microbiology and Infectious Diseases Canada (AMMI); Centers for Disease Control and Prevention (CDC). Guidelines for preventing infectious complications among hematopoietic cell transplant recipients: a global perspective. Bone Marrow Transplant. 2009;44:453-558.

İnşaat Sırasında Hematoloji Bilim Dalında Alınan Koruyucu Önlemler

Year 2016, Volume: 69 Issue: 3, 167 - 171, 21.12.2016

Abstract

Amaç: İnşaat dönemleri, bağışıklık sistemleri baskılanmış hematoloji hastaları için invaziv fungal infeksiyonlaraçısından yüksek risk taşımaktadır. Bu yazıda inşaat dönemindeki deneyimimizi paylaşmaktayız.

Gereç ve Yöntem: Hastanemizin çok yakınında yapılan inşaat nedeniyle hematoloji hastalarında meydanagelebilecek infeksiyonların engellenmesi amacıyla yaptıklarımızı ve bunların sonuçlarını burada özetlemekteyiz.

Bulgular: Hematoloji servisi ve kök hücre nakil ünitesinde tedavi edilen hastaların ve hastanenin fiziksel izolasyonu bu konuda esas önemli unsurlar olarak ortaya çıkmaktadır. Ayrıca yüksek riskli hastalarda ekstra önlem olarak antifungal profilaksi yararlıdır.

Sonuç: Bu hastalarda infeksiyon kontrolünde risk odaklı multidisipliner bir yaklaşım etkin görünmekte ve infeksiyon kontrol ekibi de kritik bir rol oynamaktadır.

Ethical Statement

Yazarlar, yazı ile ilgili herhangi bir destek almadıklarını ve herhangi bir çıkar çatışması olmadığını bildirmektedirler.

Project Number

-

References

  • 1. Clair JD, Colatrella S. Opening Pandora's (tool) Box: health care construction and associated risk for nosocomial infection. Infect Disord Drug Targets. 2013;13:177-183.
  • 2. Loo VG, Bertrand C, Dixon C, et al. Control of construction-associated nosocomial aspergillosis in an antiquated hematology unit. Infect Control Hosp Epidemiol.1996;17:360-364.
  • 3. Haiduven D. Nosocomial aspergillosis and building construction. Med Mycol. 2009;47 Suppl 1:S210-216
  • 4. Garnaud C, Brenier-Pinchart MP, Thiebaut-Bertrand A, ve ark. Seven-year surveillance of nosocomial invasive aspergillosis in a French University Hospital. J Infect. 2012;65:559-567.
  • 5. Berger J, Willinger B, Diab-Elschahawi M, et al. Effectiveness of preventive measures for hemato-oncologic patients undergoing stem cell transplantation during a period of hospital construction. Am J Infect Control. 2011;39:746-751.
  • 6. Etancelin P, Silly S, Merle V, et al. Efficacy of a multidisciplinary team for preventing hospital-acquired invasive aspergillosis: five years' experience. Pathol Biol (Paris). 2009;57:71-75.
  • 7. Klingspor L, Saaedi B, Ljungman P, Szakos A. Epidemiology and outcomes of patients with invasive mould infections: a retrospective observational study from a single centre (2005-2009).Mycoses.2015; 58:470-477.
  • 8. Neofytos D, Treadway S, Ostrander D, et al. Epidemiology, outcomes, and mortality predictors of invasive mold infections among transplant recipients: a 10-year, single-center experience. Transpl Infect Dis. 2013;15:233-242.
  • 9. Pagano L, Caira M, Nosari A, et al. Fungal infections in recipients of hematopoietic stem cell transplants: results of the SEIFEM B-2004 study--Sorveglianza Epidemiologica Infezioni Fungine Nelle Emopatie Maligne. Clin Infect Dis. 2007;45:1161-1170.
  • 10. Bassetti M, Righi E. Overview of Fungal Infections--The Italian Experience. Semin Respir Crit Care Med. 2015;36:796-805.
  • 11. Özen M, Yılmaz G, Coşkun B, ve ark. İnşaat sırasında meydana gelebilecek hematolojik enfeksiyonların engellenmesi. In: İnfeksiyon dünyası çalıştayı (20-23 Mart 2014, Ankara) Kitabı. 2014: 21.
  • 12. HolýO, Matoušková I. The importance of cleanrooms for the treatment of haematooncological patients. Wspolczesna Onkol 2012;16: 266–272.
  • 13. Özen M, Yılmaz G, Coşkun B, ve ark. A quasi-experimental study analyzing the effectiveness of portable high efficiency particulate absorption filters in preventing infections in hematology patients during construction. Turk J Hematol 2016;33:41-47
  • 14. Yılmaz Bozkurt G, Civriz Bozdag S, Topcuoglu P, ve ark. Invasive fungal infections during a construction period. Bone Marrow Transplantation. 2011; 46(Suppl. 1): 232.
  • 15. Koehler P, Cornely OA. Contemporary Strategies in the Prevention and Management of Fungal Infections. Infect Dis Clin North Am. 2015 Dec 28. pii: S0891-5520(15)00092-6.
  • 16. Ruhnke M, Arnold R, Gastmeier P. Infection control issues in patients with haematological malignancies in the era of multidrug-resistant bacteria. Lancet Oncol.2014 Dec;15(13):e606-19.
  • 17. Alothman A. Infection control and the immunocompromised host. Saudi J Kidney Dis Transpl. 2005;16:547-555.
  • 18. Simon A, Fleischhack G. Non-pharmacologic strategies to prevent and control infectious complications in pediatric hematology/oncology patients. Klin Padiatr. 2001 Sep;213 Suppl 1:A9-A21.
  • 19. Godbole G, Gant V. Respiratory tract infections in the immunocompromised.Curr Opin Pulm Med. 2013;19:244-250.
  • 20. Risi GF, Tomascak V. Prevention of infection in the immunocompromised host, Am J Infect Control 1998;26:594-606.
  • 21. Garner JS. Guideline for isolation precaution in hospitals. The Hospital Infection Control Practices Advisory Committee. Infect Control Hosp Epidemiol 1996;17:53-80.
  • 22. Oren I, Haddad N, Finkelstein R, Rowe JM. Invasive pulmonary aspergillosis in neutropenic patients during hospital construction: before and after chemoprophylaxis and institution of HEPA filters. Am J Hematol. 2001;66:257-262.
  • 23. Menegueti MG, Ferreira LR, Silva MF, et al. Assessment of microbiological air quality in hemato-oncology units and its relationship with the occurrence of invasive fungal infections: an integrative review. Rev Soc Bras Med Trop. 2013;46:391-396.
  • 24. Chang CC, Ananda-Rajah M, Belcastro A, et al. Consensus guidelines for implementation of quality processes to prevent invasive fungal disease and enhancedsurveillance measures during hospital building works, 2014. Intern Med J. 2014 Dec;44(12b):1389-1397.
  • 25. Akan H, Antia VP, Kouba M, et al. Preventing invasive fungal disease in patients with haematological malignancies and the recipients of haematopoietic stem cell transplantation: practical aspects. J Antimicrob Chemother. 2013 Nov; 68 Suppl 3:iii5-16.
  • 26. Kung HC, Johnson MD, Drew RH, et al.Clinical effectiveness of posaconazole versus fluconazole as antifungal prophylaxis in hematology-oncology patients: a retrospective cohort study. Cancer Med. 2014;3:667-673.
  • 27. Metan G, Türe Z, Pala Ç, et al. A Single Center Experience for Antifungal Prophylaxis in Patients with Acute Myelogenous Leukemia. Indian J Hematol Blood Transfus. 2015;31:339-345.
  • 28. Kidd F, Buttner C, Kressel AB. Construction: a model program for infection control compliance. Am J Infect Control. 2007;35:347-350.
  • 29. Centers for Disease Control and Prevention; Infectious Disease Society of America; American Society of Blood and Marrow Transplantation. Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. MMWR Recomm Rep. 2000 Oct;49(RR-10):1-125, CE1-7.
  • 30. Tomblyn M, Chiller T, Einsele H, et al.Center for International Blood and Marrow Transplant Research (CIBMTR); National Marrow Donor Program (NMDP); European Blood and Marrow Transplant Group (EBMT); American Society of Blood and Marrow Transplantation (ASBMT); Canadian Blood and Marrow Transplant Group (CBMTG); Infectious Disease Society of America (IDSA); Society for Healthcare Epidemiology of America (SHEA); Association of Medical Microbiology and Infectious Diseases Canada (AMMI); Centers for Disease Control and Prevention (CDC). Guidelines for preventing infectious complications among hematopoietic cell transplant recipients: a global perspective. Bone Marrow Transplant. 2009;44:453-558.
There are 30 citations in total.

Details

Primary Language English
Subjects Haematology, Infectious Diseases, Clinical Microbiology
Journal Section Articles
Authors

Mehmet Özen

Project Number -
Publication Date December 21, 2016
Published in Issue Year 2016 Volume: 69 Issue: 3

Cite

APA Özen, M. (2016). Protective Measures Against Infection During Construction in Hematology Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 69(3), 167-171.
AMA Özen M. Protective Measures Against Infection During Construction in Hematology Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası. December 2016;69(3):167-171.
Chicago Özen, Mehmet. “Protective Measures Against Infection During Construction in Hematology Patients”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 69, no. 3 (December 2016): 167-71.
EndNote Özen M (December 1, 2016) Protective Measures Against Infection During Construction in Hematology Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası 69 3 167–171.
IEEE M. Özen, “Protective Measures Against Infection During Construction in Hematology Patients”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 69, no. 3, pp. 167–171, 2016.
ISNAD Özen, Mehmet. “Protective Measures Against Infection During Construction in Hematology Patients”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 69/3 (December2016), 167-171.
JAMA Özen M. Protective Measures Against Infection During Construction in Hematology Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2016;69:167–171.
MLA Özen, Mehmet. “Protective Measures Against Infection During Construction in Hematology Patients”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 69, no. 3, 2016, pp. 167-71.
Vancouver Özen M. Protective Measures Against Infection During Construction in Hematology Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2016;69(3):167-71.