Esansiyel Hipertansiyonlu Hastalarda Enalapril Tedavisinin Böbrek Fonksiyonlarına etkisi

Year 1992, Volume: 45 Issue: 3, 517 - 528, 30.09.1992

Kenan Ateş

Abstract

We have studied the effects of an angiotensin-converting enzyme inhibitor, enalapril on systemic blood pressure and renal function in 15 patients with essential hypertension without clinical renal involvement. Systolic and diastolic blood pressures were significantly reduced during the study compared with pretreatment values (respectively p< 0.01 and p = 0.001). After a mean of 3.2 months of therapy, enalapril caused significantly decrease in microproteinuria (from 188.00 + 88.12 to 159.47 + 79.57 mg/giin, p< 0.01), and in serum uric acid (from 6.05 = 1.07 to 5.87 + 1.09 mg/dl, p< 0.05). Serum creatinine, blood urea nitrogen, and creatinine clearance were remained unchanged. By the enalapril therapy, serum sodium level was significantly decreased (p< 0.05), and serum potassium level was increased (p = 0.05). The changes in microproteinuria values during the study were significantly and positively correlated with concurrent changes in serum uric acid levels (r = 0.621, p= 0.01), However, the changes in microproteinuria and serum uric acid were not correlathe declines of systolic and diastolic blood pressure. Our data suggest that in addition to lowering and controlling systemic blood pressure, enalapril therapy may provide a renal protective effect.

Keywords

Essential hypertension , Enalapril , Serum uric acid , Microproteinuria.

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Esansiyel Hipertansiyonlu Hastalarda Enalapril Tedavisinin Böbrek Fonksiyonlarına etkisi

Abstract

Biz, klinik bébrek tutulumu bulunmayan 15 esansiyel hipertansiyonlu hastada bir «anjiotensin converting enzim» inhibitérii olan enalaprilin sistemik kan basinci ve bébrek fonksiyonlar: Uzerine etkilerini inceledik. Calisma esnasinda sistolik ve diastolik kan basinglarin da tedavi öncesi değerlere göre anlamlı azalma olmuştur {sırasıyla p< 0.01 ve p = 0.001). Ortalama 3.2 ayhk tedaviden sonra, enalapril mikroproteintiride (188.00 + 88.12’den 159.47 + 79.57 mg/gtn’e, p<0.01) ve serum tirik asitinde (6.05 + 1.07'den 5.87 = 1.09 mg/dl’ye, p<0.05) anlamli azalmalara yol acmuistir. Serum kreatinin, BUN ve kreatinin klirenste degisiklik olmamustir. Enalapril tedavisi ile serum sodyum düzeyi anlamlı olarak azalmış (p< 0.05), serum potasyum düzeyi ise artmıştır (p = 0.05), Calisma esnasinda mikroproteinuri degerlerinde gözlenen değişiklikler serum ürik asit dizeyindeki eş zamanlı degisikliklerle anlam ve pozitif olarak korelasyon göstermektedir (r = 0.621, p = 0.01). Ancak, mikroproteinuri ve serum lirik asitindeki değişiklikler sistolik ve diastolik kan basınlarındaki azalmalar ile korelasyon göstermemektedir, Verilerimiz, sistemik kan basıncının, azalması ve kontrolüne ilave olarak, enalaprilin böbrek koruyucu bir etki gösterebildiğini düşündürmektedir.

Keywords

Esansiyel hipertansiyon , Enalapril , Serum irik asiti , Mikroproteintri.

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