Testosteronun Kardiovasküler Sisteme Etkileri Üzerine Deneysel Bir Çalışma

Year 1986, Volume: 39 Issue: 2, 147 - 158, 30.06.1986

Havvanur Turgutalp

Abstract

Testesteronun meydana getirebileceği damar duvarı değişikliklerini incelemek üzere 60 deney grubu, 18 kontrol grubu sıçan üzerinde çalışıldı. Deney grubuna haftada bir kez 3,3 mg testosteron ihtiva eden
0,1 cc solüsyon, kontrol grubuna da 0,1 cc zeytinyağı intramuskuler olarak verildi.

Sıçanlar 1,2,3,4,5. ve 6. ayların sonunda eter anestezisi ile öldürülüp, kafa, göğüs ve karın boşluğundaki organlardan parçalar alındı.

Damar duvarı değişiklikleri olarak; endotelde belirginlik ve proliferasyon, intimada fokal proliferasyon ve lümene papiler çıkıntı, subadventisyal kalınlaşma, büyük damar çeperi ve endokard altında mukopolisakkarit birikiminde artma bulundu.

Keywords

testesteron , KARDİOVASKÜLER SİSTEM , Seks steroidlerin

Ethical Statement

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Supporting Institution

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Project Number

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Thanks

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An Experimental Work Concerning The Effects Of Testosterone On Cardiovascular System

Abstract

An experiment group of 60 and a control group of 18 rats were worked on to examine the alterations on vessel walls that might be caused by testosterone. A O,i cc solution containing 3,3 mg testosterone was given weekly through the i.m. route to the experiment group, whereas O,1 cc olive oil was given in the same way to the control group.

The rats were put to death with ether anesthesia at the end of Ist, 2nd, 3rd,4th, Sthand6th months and tissue examples were rereatiend from intracranial, intrathoracal and intraabdominal organs.

The vessel wall alterations which were observed; swelling and proliferation of the endothelium, papillary growth into the lumen and focal proliferation concerning the intima, subadventitial thickening, increased mucopolysaccaride accumulation on the walls of greater vessels and subendocardialIy,

As the result; it was concluded that such alterations on the: vessel walls give rise to cardiovascular disease, especially to thrombus formation.

Keywords

testosterone , CARDIOVASCULAR SYSTEM , sex steroids

Ethical Statement

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Supporting Institution

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Project Number

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Thanks

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References

• 1. Ashford TP, Freimann DG : The role of the endothelium in the initial phases of thrombosis. Am J Pathol, 506 : 253-273, 1967.
• 2. Baker PJ, Ramey ER, Ramwell PW : Androgen-mediated sex differences of cardiovascular responses in rats. Am J Physiol, 235 ; 242-246, 1978.
• 3. Bancroft JD, Stevent A : Theory and Practice of Histological oTechnigues. Churchili-Livingstone, Edinburg London, New York, 1970.
• 4. Bergentz SE : Etiology, pathogenesis and freguency of thromboembolic disease. Acta Chir Scand Suppl, 387 ; 11-14, 1968.
• 5.Bhargava KP, Dhawan KN, SaJlena ARC : Enhancement of noradrenaline pressor responses in testosterone-treated cats. Br J Pharmac Chemother, 31 : 26-31, 1967.
• 6. Campbell RSF, Lavrie TDV : The effect of 19 norandrostenolone on experimentally-induced atheroma in cockerels, Circulation Research 8 : 78-81, 1960.
• 7. Derwael E, Potuliege P, Six F,etal: A method for induction of thrombi in the rat. Arc Int Physiol Biochim, 83 : 345-348, 1975.
• 8. Deykin D : Thrombogenesis. N Eng J Med, 276 : 622-628, 1967.
• 9. Fischer GM, Swain ML : Effec tof hormones on blood pressure and vascular connective tissue in castrated and noncastrated male rats. Am J 232 : 617-621, 1977.
• 10. Goldzieher JW, Dozier TS : Oral contraceptives and thromboembolism : A reassessment. Am J Obstet Gynecol, 123 : 878-894, 1975.
• 11. Greenberg S, Heitz DC, Long JP : Testosteron-induced depressio nol adrenergic activity in the perfused canine hindlamb. Proc Soc Exptl Biol Med, 142 : 883-888, 1973.
• 12. Irey NS, Norris HJ : Intimal vascular lesions associated with female reproductive streoids. Arch Pathol, 96 ; 227-234, 1973.
• 13. Johnson M, Ramey E, Ramwell PW : Sex and age differences in human pla telet aggregation. Nature, 253-357, 1975.
• 14. Johnson M, Ramey E, Ramwell PW : Androgen-mediated sensitivity in platelet aggregation. Am J Physiol, 232 : 381-385, 1977.
• 15. Jorgenson L, Hoving T, Rowsell HC, etal: Adensine diphosphate induced pla telet aggregation and vascular injury in swine and rabbits. Am J Pathol, 61 : 161176, 1970.
• 16. Lough J, Moore S : Endotelial injury induced by thrombin or thrombi. Lab Invest, 33 : 130-135, 1975.
• 17. Marçheri VC : Disturbances of body water and circulation of blood. In : Pathology, Anderson WAD, Kissane JM, Vol: 1, 7 th Ed. The C.V. Mosby Company, Saint Louis, 1977, pp : 163-176.
• 18. Murat F, Haynes RC : Androgenes and Anabolic Steroids. In : The Pharmacological Basis of Therapeutics. 6 ih Ed. The Macmillan Company, London Toronto, 1974, pp : 1448-1465.
• 19. Patıroğlu TE : Oral Kontraseptiflerin Damar Duvarna Etkisi (Histolojik ve Histokimyasal Yöntemlerle Deneysel Çalışma), Doçentlik Tezi, Kayseri, 1980,
• 20. Uzunova A, Ramey E, Ramvwell PW : Effect of testosterone, sex and age on experimentaliy induced arterial thromosis. Nature, 261 : 712-713, 1976.
• 21. Uzunova A, Ramey E, Ramwell PW : Arachidonate-induced thrombosis in mice : Effects of gander or testosterone and eştradiol administration. Prostoglandins, 13 : 995-1003, 1977. i
• 22. Uzunova A, Ramey E, Ramwell RW : Gonadal hormones and pathogenesis of occlusive arterial thrombosis. Am J Physiol, 234 : 454-459, 1978.