İzole Büyüme Hormonu Yetersizliği (Tip 1) Gösteren Bir Ailede Büyüme Hormonu Ve Anabolik Steroidlerle Kombine Tedaviden Alınan Sonuçlar

Year 1984, Volume: 37 Issue: 3, 227 - 236, 30.09.1984

Ayten İmamoğlu

Abstract

İzole büyüme hormonu yetersizliği gösteren bir ailenin yaşları 7-15 arasında değişen 4 çocuğunda, büyüme hormonu (Crescormone) anabolik steroidlerle (Fluoxymesterone) kombine olarak sürekli ve kesintili tedavi biçimlerinde, birbirini izleyen evrelerde, total 32 aylık bir sürede uygulanmıştır. Sürekli tedavide büyüme hormonu normal dozda (haftada/kg/03-0.4 ünite) 11-17 ay verilmiştir. Yedi aylık te davisiz bir evreden sonra, düşük dozlarda kesintili tedavi (günde 1 İU, 16 günlük 2 kür) uygulanmıştır. Bütün çocuklarda büyüme velositesi artmış, bu artış sürekli tedavide kesintili tedaviye oranla çok daha belirgin olmuştur. (7.7 1.2 cm/yıl 4.6 ş- 0.9 cm/yıl) Bu değer- ler, literatürde bazı araştırıcılar tarafından yüksek doz büyüme hormonu uygulanan hastalardan elde edilen değerler ile paralellik göstermektedir. Anabolik steroidlerle kombine olarak düşük dozlarda uygulanan hormon tedavisi, hem tedavi masrafım azalttığından, hem de kemik yaşında istenmiyen bir etki oluşturmadığından, bu tip has italarda üstün tutulmalıdır

Keywords

zole büyüme hormonu , büyüme hormonu (Crescormone , yüksek doz

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Results of Combined Treatment with Growth Hormone and Anabolic Steroids in a Family with Isolated Growth Hormone Deficiency (Type 1)

Abstract

Four sibs with isolated growth hormone deficeincy ranging in age from 7 to 15 years were treated with a combination of growth hormone (Crescormone) and anabolic steroids (Fluoxymesterone) in a continous and intermittent regimen for 32 months. In continous therapy, growth hormone has been administered (0.3-0.4 IU/kg/week) for 11 to 17 months. For intermittent regimen human growth hormone was given in two courses (1 IU daily for 16 days) The growth velocity improved in all children. Mean growth velocity was 7.7 + 1.2 cm/year and 4.6 + 0.9 cm/year, for continous and intcrmittont therapy, respectively. Since these values were in accor dance with the results obtained by administering higher doses of growth hormone, we concluded that the combination of hGH with anabolic steroids in treatment of growth hormone deficiencies should be preferred. This low dose human growth hormone regimen also permits a significant reduction in the cost of hGH without causing un due advance in bone age.

Keywords

hormone , anabolic steroids , growth hormone

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