Ağrı Mediatörleri

Year 1981, Volume: 34 Issue: 1, 159 - 166, 11.08.1981

Şükrü Kaymakçalan

Abstract

Ağrı mediyatörleri, vücutta ağrı hissinin doğmasında ve santral sinir sisteminde iletilmesinde rol alp kimyasal maddeler anlamına gelir, Gerek vejetatif sinir sisteminden İnnervc olan düz adale ve glandlarda, gerekse iradi sinir sisteminden inncrve olan çizgili adelelerde merkezden gclcn effercnt impulslarm nöromediatör adı verilen kimyasal maddeler aracılığı ile olduğu bilinmektedir. Her iki sistemin periferideki duraklama yerleri olan ganglionlarda ve santral sinir sistemindeki sinapsTarda da muhtelif nöromcdiatörlerin görev aldığı kabul edilir, Bunun gibi periferiden merkeze giden affercnt sinirlerdeki iletimde de kimyasal maddelerin aracılık yapması beklenirse de bu husus henüz tam olarak aydınlanmış değildir. Görme, işitme, koku, tad ve temas duyguları ile çevreden gelen diğer çeşitli stimuluslara ait hislerin santral sinir sistemine hangi kimyasal maddeler aracılığı ile ulaştığı henüz kesinlikle bilinmemektedir.

Keywords

ağrı mediatörleri , kimyasal maddeler , düz adele

PAIN MEDIATORS

Abstract

Pain mediators are chemical substances that play a role in the emergence of the feeling of pain in the body and its transmission to the central nervous system. It is known that efferent impulses from the center are mediated by chemical substances called neuromediators in both smooth muscles and glands innervated by the vegetative nervous system and striated muscles innervated by the voluntary nervous system. It is accepted that various neuromediators are involved in the ganglia, which are the stopping points in the periphery of both systems, and in the synapses in the central nervous system. Similarly, although it is expected that chemical substances mediate the transmission in afferent nerves going from the periphery to the center, this issue has not yet been fully elucidated. It is not yet known for certain which chemical substances reach the central nervous system by means of the senses of vision, hearing, smell, taste and contact, as well as other various stimuli coming from the environment.

Keywords

pain mediators , chemicals , smooth muscle

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