Abstract
A 33-year-old man presented with a two-year history of right lower quadrant pain and episodes of bloody diarrhea. He had previously undergone an appendectomy and an unspecified laparotomy without resolution of symptoms. Suspected Crohn’s disease prompted a third laparotomy at our center, during which 120 cm of terminal ileum and adjacent mesentery were resected. Grossly, the ileal wall was thickened up to 2 cm, the lumen narrowed, and the mucosa exhibited pseudopolypoid projections and superficial ulcers. Histologically, a diffuse proliferation of spindle-shaped cells and mature ganglion-like elements infiltrated from the submucosa through the muscularis into the serosa, consistent with ganglioneuromatosis. A cutaneous neurofibroma excised three months earlier suggests an association with neurofibromatosis. We review the clinical presentation, pathology and management of gastrointestinal ganglioneuromas.
References
- 1. McCrea WBE.: A case of ganglioneuroma of the retina. Trans. Ophthalm. Soc. U. Kingd. 72:235, 1952.
- 2. Jozsa L, Steczik A, Lusztig G.: Über das primäre Ganglioneuron des Herzens. Zbl. Allg. Path. Anat. 104:257, 1963.
- 3. Willis RA.: Pathology of Tumours, 4th ed. Butterworths, London, 1967.
- 4. Henke F, Lubarsch O.: Handbuch der Speziellen Pathologischen Anatomie und Histologie: Verdauungsschlauch, Teil 3. Springer, Berlin, 1929.
- 5. Dahl EV, Waugh JM, Dahlin DC.: Gastrointestinal ganglioneuromas: brief review with report of a duodenal ganglioneuroma. Am. J. Pathol. 33:935, 1957.
- 6. Donnelly WH, Sieber WK, Yunis E.: Polypoid ganglioneurofibromatosis of the large bowel. Arch. Pathol. 87:537, 1969.
- 7. Karl JS, Shaalan AK, Horn RC Jr.: Malignant ganglioneuroma: report of an aggressively growing immature ganglioneuroma. Can. Med. Assoc. J. 85:135, 1961.
- 8. Beryl JR, Engelman K.: Diarrhea in a child with a catecholamine-secreting ganglioneuroma. J. Pediatr. 63:217, 1963.
- 9. Poate H, Inglis K.: Ganglioneuromatosis of the alimentary tract. Br. J. Surg. 16:221, 1928–29.
- 10. MacMahon JS, Davies GFS.: Plexiform ganglioneuroma of the small intestine. Aust. N. Z. J. Surg. 15:50, 1945–46.
- 11. Russell DS, Rubinstein LJ.: Pathology of Tumours of the Nervous System. Edward Arnold, London, 1960.
Abstract
References
- 1. McCrea WBE.: A case of ganglioneuroma of the retina. Trans. Ophthalm. Soc. U. Kingd. 72:235, 1952.
- 2. Jozsa L, Steczik A, Lusztig G.: Über das primäre Ganglioneuron des Herzens. Zbl. Allg. Path. Anat. 104:257, 1963.
- 3. Willis RA.: Pathology of Tumours, 4th ed. Butterworths, London, 1967.
- 4. Henke F, Lubarsch O.: Handbuch der Speziellen Pathologischen Anatomie und Histologie: Verdauungsschlauch, Teil 3. Springer, Berlin, 1929.
- 5. Dahl EV, Waugh JM, Dahlin DC.: Gastrointestinal ganglioneuromas: brief review with report of a duodenal ganglioneuroma. Am. J. Pathol. 33:935, 1957.
- 6. Donnelly WH, Sieber WK, Yunis E.: Polypoid ganglioneurofibromatosis of the large bowel. Arch. Pathol. 87:537, 1969.
- 7. Karl JS, Shaalan AK, Horn RC Jr.: Malignant ganglioneuroma: report of an aggressively growing immature ganglioneuroma. Can. Med. Assoc. J. 85:135, 1961.
- 8. Beryl JR, Engelman K.: Diarrhea in a child with a catecholamine-secreting ganglioneuroma. J. Pediatr. 63:217, 1963.
- 9. Poate H, Inglis K.: Ganglioneuromatosis of the alimentary tract. Br. J. Surg. 16:221, 1928–29.
- 10. MacMahon JS, Davies GFS.: Plexiform ganglioneuroma of the small intestine. Aust. N. Z. J. Surg. 15:50, 1945–46.
- 11. Russell DS, Rubinstein LJ.: Pathology of Tumours of the Nervous System. Edward Arnold, London, 1960.
Details
| Primary Language | English |
|---|---|
| Subjects | Pathology |
| Journal Section | Articles |
| Authors | |
| Publication Date | October 31, 1970 |
| Published in Issue | Year 1970 Volume: 23 Issue: 5 |