Abstract
This study analyzes serum protein profiles via cellulose acetate electrophoresis in 75 patients with malignant diseases, categorized into lymphomas/Hodgkin's disease, leukemia, and other malignancies. Compared to 25 healthy controls, patients displayed reductions in albumin and elevations in alpha and gamma globulin fractions. Atypical findings such as gamma peak broadening (non-homogeneity) were observed across disease groups. These alterations, while not disease-specific, reflect tumor progression and treatment response, underscoring their clinical relevance.
Keywords
Malignant diseases Serum protein electrophoresis Gamma globulin Non-homogeneous peaks Lymphoma Leukemia
References
- 1 - Cantarow A., Trumper M.: Clinical Biochemistry, 1968, London.
- 2 - Cantarow A., Schepartz B.: Biochemistry, 1967, London.
- 3 - Annino J.: Clinical Chemistry, 1964, Boston.
- 4 - Azar H.A., Hill W.T., Osserman E.F.: Malignant lymphoma and lymphatic leukemia associated with myeloma-type serum proteins. Am. J. Med. 23:239, 1967.
- 5 - Boggs D.R., Fahey J.L.: Serum protein changes in malignant diseases. J. Nat. Cancer Inst. 25:1381, 1960.
- 6 - Eastham R.D.: Biochemical values in clinical medicine, 1967.
- 7 - Koh N.J.: Das Ärztliche Laboratorium: 10:233, Berlin, 1964.
- 8 - Jim R.T.S.: Serum gamma globulin levels in chronic lymphocytic leukemia. Am. J. 234:44, 1957.
- 9 - Lohmann D., Zimmermann S., Glaser A.: Elektrophoretische Befunde bei Tumorpatienten. Dtsch. Med. Wschr. 94:213, 1969.
- 10 - Onat A.J., Cooper T.: Relation of bone marrow findings to serum protein changes in lymphosarcoma, chronic lymphocytic leukemia and Hodgkin's disease. Blood: 15:114, 1960.
- 11 - Ritzman S.E. et al.: Characterisation of paraproteins associated with malignant lymphoma. J. Lab. Clin. Med. 60:1011, 1962.
- 12 - Thomson R.H.S., King E.J.: Biochemical Disorders in Human Diseases, 1964, London.
- 13 - Ivor-Smith: Chromatographic and Electrophoretic Techniques, 1968, London.
- 14 - Tombs M., Busston D., MacLagan N.F.: Tumor proteins in human tissues. Brit. J. Cancer. 16:782, 1963.
- 15 - Viallet A. et al.: Primary carcinoma of the liver and dysproteinemia. Gastroenterology 43:88, 1962.
- 16 - Wall R.L.: Use of serum protein electrophoresis in clinical medicine. Arch. Int. Med. 102:618, 1958.
- 17 - Sunderman W., Sunderman F.W.: Serum proteins and dysproteinemias, 1964.
Abstract
Bu çalışmada, GATA Biokimya Enstitüsü laboratuvarında uygulanan cellulose acetate elektroforez tekniğiyle, 75 malign hastanın serum proteinleri incelenmiş; hastalar üç gruba ayrılmıştır: Lymphoma/Hodgkin, leukemia ve diğer malign hastalıklar. Kontrol grubu olarak 25 sağlıklı bireyin serumları da değerlendirilmiştir. Malign hastalıklarda albuminde azalma, alfa ve gamma globulin fraksiyonlarında belirgin artışlar gözlemlenmiştir. Gamma globulin piklerindeki yaygınlık, bu fraksiyonun homojen olmadığını göstermektedir. Bulgular hastalıkların ilerleyişi ve tedaviye yanıt hakkında klinik bilgi sunmakta olup, spesifik olmamakla birlikte önemli birer göstergedir.
Keywords
References
- 1 - Cantarow A., Trumper M.: Clinical Biochemistry, 1968, London.
- 2 - Cantarow A., Schepartz B.: Biochemistry, 1967, London.
- 3 - Annino J.: Clinical Chemistry, 1964, Boston.
- 4 - Azar H.A., Hill W.T., Osserman E.F.: Malignant lymphoma and lymphatic leukemia associated with myeloma-type serum proteins. Am. J. Med. 23:239, 1967.
- 5 - Boggs D.R., Fahey J.L.: Serum protein changes in malignant diseases. J. Nat. Cancer Inst. 25:1381, 1960.
- 6 - Eastham R.D.: Biochemical values in clinical medicine, 1967.
- 7 - Koh N.J.: Das Ärztliche Laboratorium: 10:233, Berlin, 1964.
- 8 - Jim R.T.S.: Serum gamma globulin levels in chronic lymphocytic leukemia. Am. J. 234:44, 1957.
- 9 - Lohmann D., Zimmermann S., Glaser A.: Elektrophoretische Befunde bei Tumorpatienten. Dtsch. Med. Wschr. 94:213, 1969.
- 10 - Onat A.J., Cooper T.: Relation of bone marrow findings to serum protein changes in lymphosarcoma, chronic lymphocytic leukemia and Hodgkin's disease. Blood: 15:114, 1960.
- 11 - Ritzman S.E. et al.: Characterisation of paraproteins associated with malignant lymphoma. J. Lab. Clin. Med. 60:1011, 1962.
- 12 - Thomson R.H.S., King E.J.: Biochemical Disorders in Human Diseases, 1964, London.
- 13 - Ivor-Smith: Chromatographic and Electrophoretic Techniques, 1968, London.
- 14 - Tombs M., Busston D., MacLagan N.F.: Tumor proteins in human tissues. Brit. J. Cancer. 16:782, 1963.
- 15 - Viallet A. et al.: Primary carcinoma of the liver and dysproteinemia. Gastroenterology 43:88, 1962.
- 16 - Wall R.L.: Use of serum protein electrophoresis in clinical medicine. Arch. Int. Med. 102:618, 1958.
- 17 - Sunderman W., Sunderman F.W.: Serum proteins and dysproteinemias, 1964.
Details
| Primary Language | English |
|---|---|
| Subjects | Medical Biochemistry - Inorganic Elements and Compounds |
| Journal Section | Articles |
| Authors | |
| Publication Date | March 31, 1970 |
| Published in Issue | Year 1970 Volume: 23 Issue: 1 |