Serum Beta-Glükuronidaz Anzim Aktivitesinin Klinik Uygulamada Önemi (I. Karaciğer Hastalıkları ile İlgisi)
Abstract
This study investigates the diagnostic and prognostic value of serum beta-glucuronidase activity in various liver diseases. Thirty-one patients diagnosed with liver and biliary conditions, confirmed via biopsy or surgery, and twenty healthy controls were analyzed. Enzyme levels were significantly elevated in mild-to-moderate portal cirrhosis, chronic active hepatitis, and obstructive jaundice cases. Serial measurements in selected patients demonstrated correlations with hepatic regeneration or failure. Statistical comparisons revealed highly significant differences (e.g., p < 0.0001 in acute hepatitis). The results support beta-glucuronidase activity as a valuable marker in assessing liver function, disease severity, and clinical course.
Keywords
Beta-glucuronidase Liver disease Portal cirrhosis Hepatitis Liver function tests Enzyme activity
References
- 1 - HAGENFELDT, L.: Serum beta-glucuronidase, glucose tolerance and atheroclerotic disease. Lancet, 1:788, 1965.
- 2 - UZUNALİMOĞLU, A.: Aterosklerozda glükoz tolerans ile serum beta glükuronidaz ve total kolesterolün mukayeseli incelenmesi (Doçentlik tezi, 1967).
- 3 - BRICAIRE, H.: Estimation de l'activité beta-glucuronidasique du sérum au cours des atteintes parenchimateuses hépatiques. Annal. Endocrinol., 25:343, 1964.
- 4 - PINEDA, E.P.: The significance of serum beta-glucuronidase activity in patients with liver disease. Gastroenterology, 36:202, 1959.
- 5 - NILIUS, R.: The serum beta-glucuronidase in liver disease. Med. Clin., 62:1082, 1967.
- 6 - GOLDBARG, J.A.: Colorimetric determination of beta-glucuronidase. Gastroenterology, 36:193, 1959.
- 7 - ERTAN, A.; PAYKOÇ, Z.; AKTAN, H.: Mide karsinomalarında mide suyundaki beta glükuronidaz aktivitesinin değeri. Ankara Üniv. Tıp Fak. Mec., 20:552, 1967.
- 8 - YOUNG, S.K.: Beta-glucuronidase studies in patients with gastric cancers. Gastroenterology, 49:50, 1965.
- 9 - PLAICE, C.H.J.: Serum beta-glucuronidase activity determination. J. Clin. Path., 14:661, 1961.
- 10 - HERINGOVA, A.: Beta-glucuronidase activity in infant serum. Acta Paediat. Scand., 55:398, 1966.
- 11 - FISHMAN, W.H.: Measurement and properties of human serum beta-glucuronidase. Clin. Chim. Acta, 15:435, 1967.
- 12 - SHERLOCK, S.: Selection of biochemical tests and active chronic hepatitis. Diseases of the Liver and Biliary System, 4th Ed., Blackwell, 1968.
- 13 - Sigma Chemical Company: Preparation of phenolphtalein glucuronidate solution. Bulletin 105-5, 1958.
- 14 - BERGMEYER, H.U.: Methods of Enzymatic Analysis, Academic Press, 1965.
- 15 - LEVY, G.A.: The Enzymes, Vol IV, Academic Press, 1960.
- 16 - MUSA, B.U.: Purification and properties of human liver beta-glucuronidase. J. Biol. Chem., 240:2811, 1965.
- 17 - KUSHINSKY, S.: Activity of beta-glucuronidase. Nature, 214:142, 1967.
- 18 - MILLS, G.T.: Factors affecting beta-glucuronidase in rat liver. Biochem. J., 53:245, 1953.
- 19 - DOHRMANN, R.: Serum beta-glucuronidase activity in internal diseases. Z. Ges. Exp. Med., 132:585, 1960.
Clinical Significance of Serum Beta-Glucuronidase Enzyme Activity (I. Its Relevance to Liver Diseases)
Abstract
Bu çalışmada, karaciğer ve safra yolu hastalıklarında serum beta-glükuronidaz aktivitesinin teşhis ve prognoz açısından önemi araştırılmıştır. Biyopsi veya cerrahi müdahale ile teşhisi doğrulanan 31 hasta ve 20 sağlıklı kontrol grubu değerlendirilmiştir. Portal sirozun hafif ve orta dereceli formlarında, kronik aktif hepatit vakalarında ve tam tıkanma sarılığı gösteren hastalarda enzim seviyeleri belirgin olarak yüksek bulunmuştur. Seri ölçümlerle yapılan takiplerde, karaciğer rejenerasyonu veya fonksiyon kaybı ile uyumlu değişimler gözlemlenmiştir. İstatistiksel analizler, bazı hasta grupları ile normaller arasında anlamlı farklılıklar olduğunu göstermiştir (örn. akut hepatit için p < 0,0001). Bulgular, serum beta-glükuronidaz aktivitesinin karaciğer hastalıklarının takibi ve değerlendirilmesinde değerli bir biyokimyasal belirteç olduğunu ortaya koymaktadır.
References
- 1 - HAGENFELDT, L.: Serum beta-glucuronidase, glucose tolerance and atheroclerotic disease. Lancet, 1:788, 1965.
- 2 - UZUNALİMOĞLU, A.: Aterosklerozda glükoz tolerans ile serum beta glükuronidaz ve total kolesterolün mukayeseli incelenmesi (Doçentlik tezi, 1967).
- 3 - BRICAIRE, H.: Estimation de l'activité beta-glucuronidasique du sérum au cours des atteintes parenchimateuses hépatiques. Annal. Endocrinol., 25:343, 1964.
- 4 - PINEDA, E.P.: The significance of serum beta-glucuronidase activity in patients with liver disease. Gastroenterology, 36:202, 1959.
- 5 - NILIUS, R.: The serum beta-glucuronidase in liver disease. Med. Clin., 62:1082, 1967.
- 6 - GOLDBARG, J.A.: Colorimetric determination of beta-glucuronidase. Gastroenterology, 36:193, 1959.
- 7 - ERTAN, A.; PAYKOÇ, Z.; AKTAN, H.: Mide karsinomalarında mide suyundaki beta glükuronidaz aktivitesinin değeri. Ankara Üniv. Tıp Fak. Mec., 20:552, 1967.
- 8 - YOUNG, S.K.: Beta-glucuronidase studies in patients with gastric cancers. Gastroenterology, 49:50, 1965.
- 9 - PLAICE, C.H.J.: Serum beta-glucuronidase activity determination. J. Clin. Path., 14:661, 1961.
- 10 - HERINGOVA, A.: Beta-glucuronidase activity in infant serum. Acta Paediat. Scand., 55:398, 1966.
- 11 - FISHMAN, W.H.: Measurement and properties of human serum beta-glucuronidase. Clin. Chim. Acta, 15:435, 1967.
- 12 - SHERLOCK, S.: Selection of biochemical tests and active chronic hepatitis. Diseases of the Liver and Biliary System, 4th Ed., Blackwell, 1968.
- 13 - Sigma Chemical Company: Preparation of phenolphtalein glucuronidate solution. Bulletin 105-5, 1958.
- 14 - BERGMEYER, H.U.: Methods of Enzymatic Analysis, Academic Press, 1965.
- 15 - LEVY, G.A.: The Enzymes, Vol IV, Academic Press, 1960.
- 16 - MUSA, B.U.: Purification and properties of human liver beta-glucuronidase. J. Biol. Chem., 240:2811, 1965.
- 17 - KUSHINSKY, S.: Activity of beta-glucuronidase. Nature, 214:142, 1967.
- 18 - MILLS, G.T.: Factors affecting beta-glucuronidase in rat liver. Biochem. J., 53:245, 1953.
- 19 - DOHRMANN, R.: Serum beta-glucuronidase activity in internal diseases. Z. Ges. Exp. Med., 132:585, 1960.
Details
| Primary Language | English |
|---|---|
| Subjects | Gastroenterology and Hepatology, Medical Biochemistry - Amino Acids and Metabolites |
| Journal Section | Articles |
| Authors | |
| Publication Date | March 31, 1970 |
| Published in Issue | Year 1970 Volume: 23 Issue: 1 |