Abstract
Inulin is widely accepted for measuring glomerular filtration rate (GFR), but its quantification poses technical and time-related difficulties. This study evaluates 131I-labeled sodium diatrizoate as an alternative for GFR determination. Eleven patients—five healthy and six with confirmed renal pathology—underwent simultaneous testing with inulin and 131I-diatrizoate. Clearance rates were calculated using plasma and urine radioactivity measurements, applying standardized equations. Mean clearance values were 108.5 mL/min for inulin and 105.7 mL/min for 131I-diatrizoate, with a mean ratio of 1.02. Results support the use of 131I-diatrizoate as a reliable and easier method for GFR assessment compared to inulin.
Keywords
Glomerular filtration rate Inulin clearance Diatrizoate Renal function Radiolabeled markers
References
- 1 - Brooks, S. A., Davies, J. W. L., Graber, I. G., Richets, C. E.: Labelling of inulin with Radioactive Iodine. Nature 188: 675.
- 2 - Burbank, M. K., Tauxe, W. N., Maher, F. T., Hunt, J. C.: Utilisation des substances marquées dans épreuves classiques de clearance rate determination. Radiology 81: 974, 1963.
- 3 - Concannon, J. P., Summers, R. F., Brewer, R., Cole, C., Wiel, C., Foster, W. D.: I125 Allyl Inulin for the determination of glomerular filtration rate. Am. J. Roentgenology 92: 302, 1964.
- 4 - Levinson, MacFate: Clinical Laboratory Diagnosis. Lea and Febiger. p. 522.
- 5 - Morris, A. M., Elwood, C., Sigman, M., Catanzaro, A.: Renal clearance of I131 labeled Meglumine Diatrizoate (Renografin) in man. J. Nucl. Med. 6: 183, 1965.
- 6 - Nelp, W. B., Wagner, H. N., Reba, R. C.: Renal excretion of vitamin B12 and its use in measurement of glomerular filtration rate in man. J. Lab. Clin. Med. 63: 103, 1964.
- 7 - Ram, M. D., Holroyd, M., Chisholm, G. D.: Measurement of glomerular filtration rate using I131-diatrizoate. Lancet. I: 7591-397, 1969.
- 8 - Sigman, E. M., Elwood, C., Reagon, M. E., Morris, A. M., Catanzaro, A.: Renal clearance of I131 labeled sodium Iothalamate in man. Investigative Urology, Aug. 1964.
- 9 - Smith, H. W.: Principles of Renal Physiology. Oxford Univ. Press, 1956.
- 10 - Tauxe, W. N., Burbank, M. K., Maher, F. T., Hunt, J. C.: Renal clearance of Radioactive Ortho-iodohippurate and diatrizoate. Mayo Clin. Proc. 39(10): 761, 1964.
- 11 - Wesson, L. G., Jr.: Glomerular and tubular factors in the excretion of sodium chloride.
- 12 - Woodruff, M. W., Malvin, R. L.: Localization of renal contrast media excretion by stop flow Analysis. J. Urol. 84: 677, 1960.
- 13 - Meschan, I., Dayton, W. E., Schmid, H. E., Watts, F. C.: Utilization of I131 labeled Renografin as an inulin substitute for renal clearance rate determination. Radiology 81: 974, 1963.
Abstract
İnülin ile glomerüler filtrasyon süratinin ölçümü yaygın bir metot olmakla birlikte, bu yöntemin teknik zorlukları ve zaman alıcı olması yeni arayışları gündeme getirmiştir. Bu çalışmada 131I ile işaretlenmiş sodium diatrizoate’ın inüline alternatif olarak glomerüler filtrasyon süratini ölçme potansiyeli değerlendirilmiştir. Beşi sağlıklı, altısı renal patolojili 11 vakada simültane olarak inülin ve 131I-diatrizoate kullanılarak plazma ve idrar örneklerinden elde edilen radyoaktivite değerleriyle klerens hesaplamaları yapılmıştır. Ortalama klerens değerleri inülin için 108.5 cc/dakika, 131I-diatrizoate için 105.7 cc/dakika olarak bulunmuş; iki yöntem arasındaki oran 1.02 olarak hesaplanmıştır. Bu sonuçlar, 131I-diatrizoate’ın glomerüler filtrasyon süratini ölçmede güvenilir ve pratik bir yöntem olduğunu göstermektedir.
References
- 1 - Brooks, S. A., Davies, J. W. L., Graber, I. G., Richets, C. E.: Labelling of inulin with Radioactive Iodine. Nature 188: 675.
- 2 - Burbank, M. K., Tauxe, W. N., Maher, F. T., Hunt, J. C.: Utilisation des substances marquées dans épreuves classiques de clearance rate determination. Radiology 81: 974, 1963.
- 3 - Concannon, J. P., Summers, R. F., Brewer, R., Cole, C., Wiel, C., Foster, W. D.: I125 Allyl Inulin for the determination of glomerular filtration rate. Am. J. Roentgenology 92: 302, 1964.
- 4 - Levinson, MacFate: Clinical Laboratory Diagnosis. Lea and Febiger. p. 522.
- 5 - Morris, A. M., Elwood, C., Sigman, M., Catanzaro, A.: Renal clearance of I131 labeled Meglumine Diatrizoate (Renografin) in man. J. Nucl. Med. 6: 183, 1965.
- 6 - Nelp, W. B., Wagner, H. N., Reba, R. C.: Renal excretion of vitamin B12 and its use in measurement of glomerular filtration rate in man. J. Lab. Clin. Med. 63: 103, 1964.
- 7 - Ram, M. D., Holroyd, M., Chisholm, G. D.: Measurement of glomerular filtration rate using I131-diatrizoate. Lancet. I: 7591-397, 1969.
- 8 - Sigman, E. M., Elwood, C., Reagon, M. E., Morris, A. M., Catanzaro, A.: Renal clearance of I131 labeled sodium Iothalamate in man. Investigative Urology, Aug. 1964.
- 9 - Smith, H. W.: Principles of Renal Physiology. Oxford Univ. Press, 1956.
- 10 - Tauxe, W. N., Burbank, M. K., Maher, F. T., Hunt, J. C.: Renal clearance of Radioactive Ortho-iodohippurate and diatrizoate. Mayo Clin. Proc. 39(10): 761, 1964.
- 11 - Wesson, L. G., Jr.: Glomerular and tubular factors in the excretion of sodium chloride.
- 12 - Woodruff, M. W., Malvin, R. L.: Localization of renal contrast media excretion by stop flow Analysis. J. Urol. 84: 677, 1960.
- 13 - Meschan, I., Dayton, W. E., Schmid, H. E., Watts, F. C.: Utilization of I131 labeled Renografin as an inulin substitute for renal clearance rate determination. Radiology 81: 974, 1963.
Details
| Primary Language | English |
|---|---|
| Subjects | Internal Diseases |
| Journal Section | Articles |
| Authors | |
| Publication Date | June 30, 1970 |
| Published in Issue | Year 1970 Volume: 23 Issue: 2 |