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Morfine Karşı Tolerans ve İptila Mekanizması

Year 1970, Volume: 23 Issue: 3, 914 - 930, 30.06.1970

Cankat Tulunay

Abstract

Morfin toleransı ve addiction hakkında literatür malümatı toplandı ve bu hadiselerin mekanizmasında rol oynayan biyojen aminler münakaşa edildi. Bilhassa beyin katekolaminleri ve serotonin ile
“morfin toleransı ve addiction arasındaki ilgi üzerinde duruldu. Son
zamanlarda büyük bir önem kazanan protein sentezi ve morfin toleransı arasındaki ilişkiden bahsedildi.

Keywords

morfin mekanizma addiction

References

  • 1-ADAMS, S. Y. YEH, L. A., WOODS, A., MITCHELL, C.L.: Drug-tesi interaction as a factor in the development of tolerance to the analgesic effect of morphine. J.P.R.T., 168: 251, 1969.
  • 2-AKERA, T.. BRODY, T. M.: 'The addiction cycle to narcotics in the rat and its relation to cathecholamines. Biochem. Pharmac., 17: 675, 1968.
  • 3-COHEN, M., KEATS, A. S., KRİVORY, W. UNGAR, G.: Efect of actinomycin D on morphine tolerance, Proc. Soc. Exp. Biol. Med, 119: 381, 1965.
  • 4-COLLIER, H. O. J.: Humoral transmitters, supersensivity, Teceptors and dependence, Scientific Basis of Drug Dependence. 5. 49-66. ed. Steinberg, H. Ghurchill L4d. 1969.
  • 5-COLLIER, H. 0. J.: Tolerance, physical dependence and receptors. Advances in Drug Research. vol. 8: 171-187, ed. Harper, N. J., Simmeonds, A. B., Acadecic Press, London, 1966.
  • 6-CONIRERAS, EH. 'TAMAYO, L.: Iofluence of changes on brain 5-hydroxytriptamine on morphine &nalgesia. Arch. Biol. Med. Exper, 4: 69, 1967.
  • 7-COX, B. M., GINSBURG, M., OSMAN, O. H.: Acute tolerance to narcotic analgesic drugs in rats. Br. J. Phanmac. Chemother. 88: 245, 1968.
  • 8-COX, B. M., GINSBURG, M.: Is there a relationship between protein synihesis and tolerance to analgesic drug. Scientific of Drug Dependence. s. 77-86, ed. Steinberg, H. Churchill Ltd. 1969.
  • 9-EDDY, N.B.: Action on the nervous system. The Pharmacology of the Opium Alkaloids, I, U.S.A. Pub. Health Rep. Supp. 165. ed. Kruger, H. Edy, N. B., Sumwalt, M., Weshington, 1941.
  • 10-EDDI, N. B.: Tolerance and adiction. The Pharmacology of the Opium Alkaloids, 1. s. 719-757. Ed. Kruger, H., Eddy, N. B., Sumwalt M., U.S.A. Pub. Hip. Rep. Supp. 165, Washington, 1941.
  • 11-EISENMAN, A.J. SLOAN, J. W. MARTIN, W.R. JASINSKI, D.R,,
  • 12-BROOKS, J. W.: Catecholamines and 17-hydroxycorticosteroid excretion during a cycle of morphine dependence in man, Nat. Res. Coun. Rep. &. 5412, 1968.
  • 13-FERGUSON, R. K.,, ADAMS, W. J., MITCHELL, C, L.: Studies of tolerance development to morphine analgesia in rets tested on the hot plate. Burop. J. Pharmacol. 8: 83, 1969.
  • 14-FERGUSON, R. K., MITCHELL, C. L.: Pain asa factor in the development of tolerance to morphine analgesia in man. Clin. Pharm. Therap, 10: 372, 1969.
  • 15-GUNNE, L. M.: Cathecolamines and 5-hydroxytryptamine in morphine tolarence and withdraval, Acta Physiol. Scand. 58: supp. 204, 1968.
  • 16-GUNNE, L.M.: Some pharmacological agents modifying the morphine abstinence syndrome in dogs. Arch, İnt. Pharmacodyn, 157: 293, 1965.
  • 17-GUNNE, L. M., JONSSON, J., FUXE, K.: Effects of morphine intoxication on brain catecholamine neurons. Europ. J. Pharmacol, 5: 388, 1969.
  • 18-JACOP, J,, LOISEU, G,, GARIN, P.E, BARTHELEMY, C., LAJIFIRLLE, C.: Antagonismes vis-a-vis de la morphine ches la souris. Arch. int. Pharmacodyn. 148: 14, 1964.
  • 19-KAYAN, S. MITCHELL, C. L.: Further studies on the development if tolerance to the analgesic effect of morphine, Arch. int. Pharmacodyn. 182: 287, 1969.
  • 20-LOH, H. H. SHEN, F. H., WAY, E. 1: İnhibition of morphine tolerance and physical depedence development and brain serotoin synthesis by eycloheximide. Biochem. Pharmaco., 18: 2711, 1969.
  • 21-LOMAX, P., KIRKPATRICK, W. B.: The effect of N-aliyi normorphine on the development of acute tolerance to the analgesic and hypothermic effects of morphine in the rat. Med. Pharmacol, exp. 16: 165, 1967.
  • 22-LOTTI, V.J., LOMAX, P., GEORGE, R.: Acute tolerance to morphine following systemic and intracerebral injection in the rat. Int, J. Neuropharmacol. 5: 35, 1966.
  • 23-MARTIN, W. R, EADES, G..G.: oDemonstration of tolerance and physical dependence in the dog following a short-term infusion of morphine. J.P.R,T. 133: 262, 1961.
  • 24-MAYNERT, E. W.: Some aspects of the comparative pharmacology of morphine. Fed. Proc., 26: 1111, 1967.
  • 25-NEAL, M.J.: Failure of morphine dependence in rats to influence brain noradrenaline turnover. J. Pharm, Pharmac. 20: 950, 1968.
  • 26-REYNOLDS, A. K., RANDALL, L. O.: Morphine ând alilied drugs. S5. 124-144, Univ. Toronto Press, 1957. i
  • 27-SEBVERS, M. H. DENEAU, G, A.: Physiological aspects of tolerance and physical dependence. Physiological Pharmacology, 1: 565, 1963.
  • 28-SEEVERS, M.H., WOODS, L. A.: The phenomena of tolerance, Am, J. Med. 14; 546, 1953,
  • 29-SHEN, EF. LOH, H.H. WAY, E. 1L.: Brain serotonin turnover and tolerance development to morphine. Pharmacologist, 2: 323, 1968. TAKAGI, Hİ, TAKASHIMA, T., KIMURA, K.: Antegonism of theanalgetic effect of morphine in.mice by tetrabenazine and reserpine.Areh. int. Pharmacodyn. 149: 484, 1964.
  • 30 — TATUM, A 1., SEBEVERS, M. H.: Theories of drug addiction. Physiol.Rev. 40: 107, 1931.
  • 31 — TATUM, A. L. SEEVERS, M. H., COLLINS:. Theories of drug addiction. J.P.E.T., 36: 447, 1929.
  • 32 — 'TENEN, S. S.:Antagonism, of the analgesic effect of morphine and other | drugs by p-chiorophenylalanine, a serotonin depletor, Psychopharmacol.(Berlin), 1Z: 218, 1968
  • 33-,'TIRRI, R.: Transfer of induced tolerance to morphine and promazine by brain homogenate. Experientia. 23: 278, 1967.
  • 34 — TÜRKER, K., AKÇASU, A.: The öffect of morphine on serotonin *'coh-. tent of cats brain, New İstanbul Contr. Clin. Scien. 5: 89, 1962.
  • 35 — UNGAR,. G, COHEN, MM. Induction of morphine tolerance material© extracted from prâin of tolerant animals, Int. J. Neuropharmacot. 5: 163, 1966, i
  • 36 — VOGT M.: Catecholamines in brain, Pharmacol, Rev. 11: 483, 1959,
  • 37-WAY, E. L., LOH.H,, SHEN, F.H.: . Simultaneous guantitative assess- ment of morphine : tolarence and physical dependence, J.P.E,T. 167: 1, 1969.
  • 38-WAX, B.L, LOH, H.H. SHEN, EF, H.: Morphine tolerance, physical Na dependence, and synthesis of brain © AydrGkytiyptamine, Science. 162: 1290, 1968.
  • 39 — Wild. Hith, Org. Techn. Rep. Ser. 273: 9, 1964,
  • 40 — Wid. Hith, Org. Techn. Rep. Ser. 287: 4, 1964.
  • 41 -— WOODS, L.A.: Distribution and fate of mef'phine in non- wtolerant and tolerant dogs, and rats. J.P.R:T. 112: 158, 1954.
  • 42 — VEDERNIKOV, YU. P., AFRIKANOV, 1. 1:, On'the role of a central adrenergic mechanism in morphine analgesic action. J. Pharm. Pharmac. 21: 845, 1969,

Mechanism of Tolerance and Addiction to Morphine

Year 1970, Volume: 23 Issue: 3, 914 - 930, 30.06.1970

Cankat Tulunay

Abstract

Literature information on morphine tolerance and addiction was collected and biogenic amines involved in the mechanism of these events were discussed. In particular, the relationship between brain catecholamines and serotonin and morphine tolerance and addiction was emphasized. The relationship between protein synthesis and morphine tolerance, which has recently gained great importance, was mentioned.

Keywords

addiction mekanizma morfin

References

  • 1-ADAMS, S. Y. YEH, L. A., WOODS, A., MITCHELL, C.L.: Drug-tesi interaction as a factor in the development of tolerance to the analgesic effect of morphine. J.P.R.T., 168: 251, 1969.
  • 2-AKERA, T.. BRODY, T. M.: 'The addiction cycle to narcotics in the rat and its relation to cathecholamines. Biochem. Pharmac., 17: 675, 1968.
  • 3-COHEN, M., KEATS, A. S., KRİVORY, W. UNGAR, G.: Efect of actinomycin D on morphine tolerance, Proc. Soc. Exp. Biol. Med, 119: 381, 1965.
  • 4-COLLIER, H. O. J.: Humoral transmitters, supersensivity, Teceptors and dependence, Scientific Basis of Drug Dependence. 5. 49-66. ed. Steinberg, H. Ghurchill L4d. 1969.
  • 5-COLLIER, H. 0. J.: Tolerance, physical dependence and receptors. Advances in Drug Research. vol. 8: 171-187, ed. Harper, N. J., Simmeonds, A. B., Acadecic Press, London, 1966.
  • 6-CONIRERAS, EH. 'TAMAYO, L.: Iofluence of changes on brain 5-hydroxytriptamine on morphine &nalgesia. Arch. Biol. Med. Exper, 4: 69, 1967.
  • 7-COX, B. M., GINSBURG, M., OSMAN, O. H.: Acute tolerance to narcotic analgesic drugs in rats. Br. J. Phanmac. Chemother. 88: 245, 1968.
  • 8-COX, B. M., GINSBURG, M.: Is there a relationship between protein synihesis and tolerance to analgesic drug. Scientific of Drug Dependence. s. 77-86, ed. Steinberg, H. Churchill Ltd. 1969.
  • 9-EDDY, N.B.: Action on the nervous system. The Pharmacology of the Opium Alkaloids, I, U.S.A. Pub. Health Rep. Supp. 165. ed. Kruger, H. Edy, N. B., Sumwalt, M., Weshington, 1941.
  • 10-EDDI, N. B.: Tolerance and adiction. The Pharmacology of the Opium Alkaloids, 1. s. 719-757. Ed. Kruger, H., Eddy, N. B., Sumwalt M., U.S.A. Pub. Hip. Rep. Supp. 165, Washington, 1941.
  • 11-EISENMAN, A.J. SLOAN, J. W. MARTIN, W.R. JASINSKI, D.R,,
  • 12-BROOKS, J. W.: Catecholamines and 17-hydroxycorticosteroid excretion during a cycle of morphine dependence in man, Nat. Res. Coun. Rep. &. 5412, 1968.
  • 13-FERGUSON, R. K.,, ADAMS, W. J., MITCHELL, C, L.: Studies of tolerance development to morphine analgesia in rets tested on the hot plate. Burop. J. Pharmacol. 8: 83, 1969.
  • 14-FERGUSON, R. K., MITCHELL, C. L.: Pain asa factor in the development of tolerance to morphine analgesia in man. Clin. Pharm. Therap, 10: 372, 1969.
  • 15-GUNNE, L. M.: Cathecolamines and 5-hydroxytryptamine in morphine tolarence and withdraval, Acta Physiol. Scand. 58: supp. 204, 1968.
  • 16-GUNNE, L.M.: Some pharmacological agents modifying the morphine abstinence syndrome in dogs. Arch, İnt. Pharmacodyn, 157: 293, 1965.
  • 17-GUNNE, L. M., JONSSON, J., FUXE, K.: Effects of morphine intoxication on brain catecholamine neurons. Europ. J. Pharmacol, 5: 388, 1969.
  • 18-JACOP, J,, LOISEU, G,, GARIN, P.E, BARTHELEMY, C., LAJIFIRLLE, C.: Antagonismes vis-a-vis de la morphine ches la souris. Arch. int. Pharmacodyn. 148: 14, 1964.
  • 19-KAYAN, S. MITCHELL, C. L.: Further studies on the development if tolerance to the analgesic effect of morphine, Arch. int. Pharmacodyn. 182: 287, 1969.
  • 20-LOH, H. H. SHEN, F. H., WAY, E. 1: İnhibition of morphine tolerance and physical depedence development and brain serotoin synthesis by eycloheximide. Biochem. Pharmaco., 18: 2711, 1969.
  • 21-LOMAX, P., KIRKPATRICK, W. B.: The effect of N-aliyi normorphine on the development of acute tolerance to the analgesic and hypothermic effects of morphine in the rat. Med. Pharmacol, exp. 16: 165, 1967.
  • 22-LOTTI, V.J., LOMAX, P., GEORGE, R.: Acute tolerance to morphine following systemic and intracerebral injection in the rat. Int, J. Neuropharmacol. 5: 35, 1966.
  • 23-MARTIN, W. R, EADES, G..G.: oDemonstration of tolerance and physical dependence in the dog following a short-term infusion of morphine. J.P.R,T. 133: 262, 1961.
  • 24-MAYNERT, E. W.: Some aspects of the comparative pharmacology of morphine. Fed. Proc., 26: 1111, 1967.
  • 25-NEAL, M.J.: Failure of morphine dependence in rats to influence brain noradrenaline turnover. J. Pharm, Pharmac. 20: 950, 1968.
  • 26-REYNOLDS, A. K., RANDALL, L. O.: Morphine ând alilied drugs. S5. 124-144, Univ. Toronto Press, 1957. i
  • 27-SEBVERS, M. H. DENEAU, G, A.: Physiological aspects of tolerance and physical dependence. Physiological Pharmacology, 1: 565, 1963.
  • 28-SEEVERS, M.H., WOODS, L. A.: The phenomena of tolerance, Am, J. Med. 14; 546, 1953,
  • 29-SHEN, EF. LOH, H.H. WAY, E. 1L.: Brain serotonin turnover and tolerance development to morphine. Pharmacologist, 2: 323, 1968. TAKAGI, Hİ, TAKASHIMA, T., KIMURA, K.: Antegonism of theanalgetic effect of morphine in.mice by tetrabenazine and reserpine.Areh. int. Pharmacodyn. 149: 484, 1964.
  • 30 — TATUM, A 1., SEBEVERS, M. H.: Theories of drug addiction. Physiol.Rev. 40: 107, 1931.
  • 31 — TATUM, A. L. SEEVERS, M. H., COLLINS:. Theories of drug addiction. J.P.E.T., 36: 447, 1929.
  • 32 — 'TENEN, S. S.:Antagonism, of the analgesic effect of morphine and other | drugs by p-chiorophenylalanine, a serotonin depletor, Psychopharmacol.(Berlin), 1Z: 218, 1968
  • 33-,'TIRRI, R.: Transfer of induced tolerance to morphine and promazine by brain homogenate. Experientia. 23: 278, 1967.
  • 34 — TÜRKER, K., AKÇASU, A.: The öffect of morphine on serotonin *'coh-. tent of cats brain, New İstanbul Contr. Clin. Scien. 5: 89, 1962.
  • 35 — UNGAR,. G, COHEN, MM. Induction of morphine tolerance material© extracted from prâin of tolerant animals, Int. J. Neuropharmacot. 5: 163, 1966, i
  • 36 — VOGT M.: Catecholamines in brain, Pharmacol, Rev. 11: 483, 1959,
  • 37-WAY, E. L., LOH.H,, SHEN, F.H.: . Simultaneous guantitative assess- ment of morphine : tolarence and physical dependence, J.P.E,T. 167: 1, 1969.
  • 38-WAX, B.L, LOH, H.H. SHEN, EF, H.: Morphine tolerance, physical Na dependence, and synthesis of brain © AydrGkytiyptamine, Science. 162: 1290, 1968.
  • 39 — Wild. Hith, Org. Techn. Rep. Ser. 273: 9, 1964,
  • 40 — Wid. Hith, Org. Techn. Rep. Ser. 287: 4, 1964.
  • 41 -— WOODS, L.A.: Distribution and fate of mef'phine in non- wtolerant and tolerant dogs, and rats. J.P.R:T. 112: 158, 1954.
  • 42 — VEDERNIKOV, YU. P., AFRIKANOV, 1. 1:, On'the role of a central adrenergic mechanism in morphine analgesic action. J. Pharm. Pharmac. 21: 845, 1969,
There are 42 citations in total.

Details

Primary Language English
Subjects Basic Pharmacology
Journal Section Articles
Authors

Cankat Tulunay This is me

Publication Date June 30, 1970
Published in Issue Year 1970 Volume: 23 Issue: 3

Cite

APA Tulunay, C. (1970). Mechanism of Tolerance and Addiction to Morphine. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 23(3), 914-930.
AMA Tulunay C. Mechanism of Tolerance and Addiction to Morphine. Ankara Üniversitesi Tıp Fakültesi Mecmuası. June 1970;23(3):914-930.
Chicago Tulunay, Cankat. “Mechanism of Tolerance and Addiction to Morphine”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 23, no. 3 (June 1970): 914-30.
EndNote Tulunay C (June 1, 1970) Mechanism of Tolerance and Addiction to Morphine. Ankara Üniversitesi Tıp Fakültesi Mecmuası 23 3 914–930.
IEEE C. Tulunay, “Mechanism of Tolerance and Addiction to Morphine”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 23, no. 3, pp. 914–930, 1970.
ISNAD Tulunay, Cankat. “Mechanism of Tolerance and Addiction to Morphine”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 23/3 (June1970), 914-930.
JAMA Tulunay C. Mechanism of Tolerance and Addiction to Morphine. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1970;23:914–930.
MLA Tulunay, Cankat. “Mechanism of Tolerance and Addiction to Morphine”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 23, no. 3, 1970, pp. 914-30.
Vancouver Tulunay C. Mechanism of Tolerance and Addiction to Morphine. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1970;23(3):914-30.