Hepatit B Antijenemisi (HBAg) ile Birlikte Olan Glomerulopatiler (2 Olgu Nedeniyle)

Year 1981, Volume: 34 Issue: 4, 715 - 720, 31.12.1981

Necmiye / Nurten / Ayşe F. / Ayşe / Saadet Tümer / Girgin / Yüksel / Pekyılmaz / Deniz

Abstract

Two male pediatric patients (aged 8 and 4) presenting with nephrotic syndrome and macroscopic hematuria were investigated for renal and hepatic pathology. Both cases tested positive for hepatitis B surface antigen (HBAg). Renal biopsies revealed membranoproliferative glomerulonephritis in one patient and membranous nephropathy in the other. Liver biopsies in both cases demonstrated cirrhosis. Laboratory findings showed proteinuria, hematuria, normal complement levels, and elevated serum lipids. Although immunofluorescent detection of HBsAg complexes was not performed, the clinicopathologic correlation supports the possibility that immune complexes formed by hepatitis B viral antigens may play a role in the development of secondary glomerular pathology.

Keywords

hepatitis B antigen, nephrotic syndrome, glomerulonephritis, membranous nephropathy, membranoproliferative glomerulonephritis, liver cirrhosis

Glomerulopathies Associated With Positive HBAg (2 Cases)

Abstract

Nefrotik sendrom ve belirgin hematüri bulguları ile başvuran biri 8 yaşında, diğeri 4 yaşında olan iki erkek çocukta hepatit B yüzey antijeni (HBAg) pozitif bulunmuştur. Her iki olguya böbrek ve karaciğer biyopsisi uygulanmıştır. İlk olguda membranoproliferatif glomerülonefrit ve siroz, ikinci olguda ise membranöz nefropati ve siroz saptanmıştır. Laboratuvar bulgularında ileri derecede proteinüri, hematüri, normal serum kompleman düzeyleri ve yüksek serum lipidleri izlenmiştir. Her ne kadar immün floresan çalışması yapılamamış olsa da, klinik ve histopatolojik bulgular hepatit B antijen-antikor komplekslerinin ikincil glomerülopatilere neden olabileceğini düşündürmektedir.

Keywords

hepatit B antijeni, nefrotik sendrom, glomerülonefrit, membranöz nefropati, membranoproliferatif glomerülonefrit, karaciğer sirozu

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