Investigation of Immunoglobulin Levels in Cord Serum of Infants Born to Socioeconomically Disadvantaged Mothers
Abstract
Bu çalışma, sosyo-ekonomik düzeyi düşük olan 30 annenin doğumunda hem annelerin hem de 31 yenidoğanın kordon serumlarındaki IgG, IgM ve IgA seviyelerini karşılaştırmalı olarak incelemektedir. Bulgular, IgG seviyelerinin anne ve çocuk arasında anlamlı fark göstermediğini ortaya koymuştur; bu, IgG’nin transplasental geçişini yansıtan beklenen bir durumdur. IgM seviyeleri büyük ölçüde düşük bulunmuş, yalnızca dört vakada 20–31 mg/100 ml arasında değerler gözlemlenmiştir. IgA ise yalnızca iki vakada yüksek düzeyde saptanmıştır ve bu yükseklik plasental hasar sonucu anne IgA’sının fetal dolaşıma geçmesi olasılığıyla açıklanmıştır. Çalışma, kordon serumundaki immünoglobulinlerin analizinin intrauterin enfeksiyon varlığına dair ipuçları sunabileceğini vurgulamaktadır.
References
- 1 - Allansmith, M., McLellan, B. H., Butterworth, M. and Malomey, J. R.: The development of immunoglobulin levels in man. J. Pediatrics, 72: 276, 1968.
- 2 - Eichenwald, H. F. and Shinefield, H. R.: Antibody Production by the human fetus. J. Pediatrics, 63: 870, 1973.
- 3 - Fahey, J. L.: Antibodies and immunoglobulins. Normal development and changes in disease. J.A.M.A., 194: 255, 1965.
- 4 - Fulginity, V. A., Sieber, O. F., Claman, H. N. and Merrill, D.: Serum immunoglobulin measurement during the first year of life and in immunoglobulin deficiency states. J. Pediatrics, 68: 723, 1966.
- 5 - Gitlin, D.: Protein metabolism, cell formation and immunity. Pediatrics, 34: 198, 1964.
- 6 - Hardy, J. B., McCracken, G. H., Mellitis, E. D., Gilkeson, M. R. and Sever, J. I.: Serum immunoglobulin levels in newborn infants. J. Pediatrics, 75: 1211, 1969.
- 7 - McCracken, G. H., Chen, T. C., Hardy, J. B. and Tzan, N.: Serum immunoglobulin levels in newborn infants I. evaluation of a radial diffusion plate method. J. Pediatrics, 74: 378, 1969.
- 8 - McCracken, G. H., Hardy, J. B., Chen, T. C., Hoffman L. S., Gilkeson M. R. and Sever J. I.: Serum immunoglobulin levels in newborn infants II. Survey of cord and follow-up sera from 123 infants with congenital rubella. J. Pediatrics, 74: 383, 1969.
- 9 - McCracken, G. H., Shinefield H. R.: Immunoglobulin concentration in newborn infants with congenital cytomegalic inclusion disease. Pediatrics, 36: 933, 1965.
- 10 - McKay E., Thom H. and Gray, D.: Immunoglobulins in umbilical cord plasma. Congenital deformities, other abnormalities and multiple pregnancies. Arch. Dis. Childh., 42: 264, 1967.
- 11 - Sever, J. I., Hardy, J. B., Korones S. B., Gilkeson M. R., Corridon L., Let A., Tzan N. and Yarnick D.: Cord immunoglobulins in a middle class Caucasian population. J. Pediatrics, 75: 1224, 1969.
- 12 - Stiehm E. R., Ammann A. J. and Cherry J. D.: Elevated cord macroglobulins in the diagnosis of intrauterine infections. New England J. Med., 275: 971, 1966.
- 13 - Stiehm E. R., and Fudenberg H. H.: Serum levels of immunoglobulins in health and disease. A survey. Pediatrics, 37: 715, 1966.
- 14 - Susan, P. W.: The transplacental passage of immunoglobulins. Hospital Bulletin, 27: 10, 1972.
- 15 - Thom, H., McKay E., Gray D.: Immunoglobulins in umbilical cord plasma of healthy infants. Arch. Dis. Childh., 42: 259, 1967.
Sosyo-Ekonomik Durumu İyi Olmayan Annelerden Doğan Çocukların Kordon Serumunda İmmunoglobulin Seviyelerinin Tetkiki
Abstract
This study examines and compares IgG, IgM, and IgA levels in cord serum of 31 newborns and serum of 30 mothers with low socioeconomic status. Findings show no significant difference in IgG levels between mothers and infants, reflecting expected transplacental transfer. IgM levels were generally low, with only four cases presenting values between 20–31 mg/100 ml. IgA was detected in only two cases, with elevated levels possibly due to placental damage allowing maternal IgA to enter fetal circulation. The study highlights the potential role of cord serum immunoglobulin profiling in indicating intrauterine infection or transplacental protein transfer anomalies.
References
- 1 - Allansmith, M., McLellan, B. H., Butterworth, M. and Malomey, J. R.: The development of immunoglobulin levels in man. J. Pediatrics, 72: 276, 1968.
- 2 - Eichenwald, H. F. and Shinefield, H. R.: Antibody Production by the human fetus. J. Pediatrics, 63: 870, 1973.
- 3 - Fahey, J. L.: Antibodies and immunoglobulins. Normal development and changes in disease. J.A.M.A., 194: 255, 1965.
- 4 - Fulginity, V. A., Sieber, O. F., Claman, H. N. and Merrill, D.: Serum immunoglobulin measurement during the first year of life and in immunoglobulin deficiency states. J. Pediatrics, 68: 723, 1966.
- 5 - Gitlin, D.: Protein metabolism, cell formation and immunity. Pediatrics, 34: 198, 1964.
- 6 - Hardy, J. B., McCracken, G. H., Mellitis, E. D., Gilkeson, M. R. and Sever, J. I.: Serum immunoglobulin levels in newborn infants. J. Pediatrics, 75: 1211, 1969.
- 7 - McCracken, G. H., Chen, T. C., Hardy, J. B. and Tzan, N.: Serum immunoglobulin levels in newborn infants I. evaluation of a radial diffusion plate method. J. Pediatrics, 74: 378, 1969.
- 8 - McCracken, G. H., Hardy, J. B., Chen, T. C., Hoffman L. S., Gilkeson M. R. and Sever J. I.: Serum immunoglobulin levels in newborn infants II. Survey of cord and follow-up sera from 123 infants with congenital rubella. J. Pediatrics, 74: 383, 1969.
- 9 - McCracken, G. H., Shinefield H. R.: Immunoglobulin concentration in newborn infants with congenital cytomegalic inclusion disease. Pediatrics, 36: 933, 1965.
- 10 - McKay E., Thom H. and Gray, D.: Immunoglobulins in umbilical cord plasma. Congenital deformities, other abnormalities and multiple pregnancies. Arch. Dis. Childh., 42: 264, 1967.
- 11 - Sever, J. I., Hardy, J. B., Korones S. B., Gilkeson M. R., Corridon L., Let A., Tzan N. and Yarnick D.: Cord immunoglobulins in a middle class Caucasian population. J. Pediatrics, 75: 1224, 1969.
- 12 - Stiehm E. R., Ammann A. J. and Cherry J. D.: Elevated cord macroglobulins in the diagnosis of intrauterine infections. New England J. Med., 275: 971, 1966.
- 13 - Stiehm E. R., and Fudenberg H. H.: Serum levels of immunoglobulins in health and disease. A survey. Pediatrics, 37: 715, 1966.
- 14 - Susan, P. W.: The transplacental passage of immunoglobulins. Hospital Bulletin, 27: 10, 1972.
- 15 - Thom, H., McKay E., Gray D.: Immunoglobulins in umbilical cord plasma of healthy infants. Arch. Dis. Childh., 42: 259, 1967.
Details
| Primary Language | English |
|---|---|
| Subjects | Disease Surveillance |
| Journal Section | Articles |
| Authors | |
| Publication Date | December 31, 1973 |
| Published in Issue | Year 1973 Volume: 26 Issue: 5-6 |