Systematic Reviews and Meta Analysis
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Erythroleukemia Associated with Fetal Pattern of Erythropoiesis: A Case Characterized by Elevated Fetal Hemoglobin and Decreased A. Hemoglobin

Year 1973, Volume: 26 Issue: 5-6, 1267 - 1276, 31.12.1973

Ayten Arcasoy

Abstract

Bu çalışma, ileri düzeyde fötal hemoglobin artışı (%56) ve A. hemoglobinde ciddi azalma (%0.25–0.26) ile karakterize, akut myeloblastik lösemiye dönüşen nadir bir eritrolösemi vakasını sunmaktadır. Altı yaşındaki erkek çocukta hepatosplenomegali, anemi, trombositopeni ve periferik kanda %20 oranında çekirdekli eritrosit gözlemlenmiştir. Kemik iliğinde eritroid hiperplazi saptanmış, vakada thalassemia majoru düşündürecek şekilde yüksek HbF düzeyi bulunmuş; ancak lösemiye özgü blast hücre varlığı tanıda ayırıcı olmuştur. Dörtlü kemoterapiye yanıt yetersiz olmuş ve hasta 19. günde kontrolsüz kanamalar nedeniyle exitus olmuştur. Bulgular, edinilmiş hematolojik hastalıklarda fötal eritropoezin devam edebileceğini ve bunun lösemi patogeneziyle ilişkili olabileceğini göstermektedir.

Keywords

hemoglobin eritropoez fötal

References

  • 1 - Weatherall, D. J., and Clegg, J. B.: The Thalassemia Syndromes, p.140. Blackwell Scientific Publications, London-Edinburgh, 1972.
  • 2 - Mauer, M. M.: Pediatric Hematology, p.94. McGraw-Hill Book Company, New York, 1969.
  • 3 - Miller, D. R.: Raised fetal hemoglobin in childhood leukemia. Brit. J. Haematol., 17: 103, 1969.
  • 4 - Maurer, H. S., Vido, L. N., and Honig, G. R.: Similarities of juvenile chronic myelogenous leukemia to fetal erythrocytes. Blood, 39(6): 1072.
  • 5 - Weatherall, D. J., Edwards, J. A., Donohoe, W. T. A.: Hemoglobin and red cell enzyme changes in juvenile myeloid leukemia. Brit. J. Haematol., 1: 679, 1969.
  • 6 - Cao, A.: Juvenile chronic myeloid leukemia. Lancet, 1: 1002, 1970.
  • 6a - Cao, A., Leone, N., Trabalzo, N., and Virgiliis, D. S.: Clinical and hematological findings in juvenile type chronic myeloid leukemia. Minerva Pediatrica, 21: 1649, 1969.
  • 7 - Shapira, Y., Polliack, A., Cividalle, G., and Rachmilewitz, E.: Juvenile myeloid leukemia with fetal erythropoiesis. Cancer, 30: 353, 1972.
  • 8 - Bloom, G. E., Gerald, P. S., and Diamont, L. K.: Chronic myelogenous leukemia in an infant. Serial cytogenetic and fetal hemoglobin studies. Pediatrics, 28: 295, 1966.
  • 9 - Stoppoloni, G., Ditaro, R.: Juvenile chronic myeloid leukemia. Lancet, 1: 1176, 1970.
  • 10 - Horton, B. F., and Chernoff, A. I.: The hemoglobin profile in erythroleukemia. Cancer, 26, 1970.
  • 11 - Weatherall, D. J., Brown, N. J.: Juvenile chronic myeloid leukemia. Lancet, 1: 7645: 526, 1970.
  • 12 - Singer, K., Chernoff, A. I., and Singer, J.: Studies on abnormal hemoglobins—alkali denaturation. Blood, 6: 913, 1951.
  • 13 - Kunkel, H. G., Vallenanus, G.: Hemoglobin in normal adult blood. Science, 122: 288, 1955.
  • 14 - Kahn, A., Bovin, P., Wroklans, M., Hakim, J.: Erythroleukemia with dual erythrocyte population: Weakening of blood group antigens, major deficiency in adenylate kinase, and increase in A hemoglobin fraction. Nouvelle Revue Française d’Hématologie, 12: 609, 1972.
  • 15 - Aksoy, M., and Erdem, S.: Decrease in A hemoglobin concentration during erythroleukemia. Nature, 213: 522, 1967.
  • 16 - Williams, J., et al.: Hematology, McGraw-Hill Book Company, New York, p.699, 1972.

Fötal Eritropoezle Seyreden Eritrolösemi: Fötal Hemoglobinde Artış ve A. Hemoglobinde Azalma ile Karakterize Bir Vaka

Year 1973, Volume: 26 Issue: 5-6, 1267 - 1276, 31.12.1973

Ayten Arcasoy

Abstract

This paper presents a rare case of erythroleukemia marked by significantly increased fetal hemoglobin (56%) and reduced A. hemoglobin (0.25–0.26%), ultimately transitioning into acute myeloblastic leukemia. A six-year-old boy exhibited hepatosplenomegaly, severe anemia, thrombocytopenia, and 20% nucleated erythrocytes in peripheral blood. Bone marrow revealed erythroid hyperplasia; despite thalassemia-like HbF levels, the presence of leukemic blasts distinguished the diagnosis. The patient did not respond to quadruple chemotherapy and succumbed to hemorrhagic complications on the 19th day. Findings suggest that persistent fetal erythropoiesis may occur in acquired hematologic malignancies, highlighting its potential role in leukemogenesis.

Keywords

eritropoez hemoglobin fetal

References

  • 1 - Weatherall, D. J., and Clegg, J. B.: The Thalassemia Syndromes, p.140. Blackwell Scientific Publications, London-Edinburgh, 1972.
  • 2 - Mauer, M. M.: Pediatric Hematology, p.94. McGraw-Hill Book Company, New York, 1969.
  • 3 - Miller, D. R.: Raised fetal hemoglobin in childhood leukemia. Brit. J. Haematol., 17: 103, 1969.
  • 4 - Maurer, H. S., Vido, L. N., and Honig, G. R.: Similarities of juvenile chronic myelogenous leukemia to fetal erythrocytes. Blood, 39(6): 1072.
  • 5 - Weatherall, D. J., Edwards, J. A., Donohoe, W. T. A.: Hemoglobin and red cell enzyme changes in juvenile myeloid leukemia. Brit. J. Haematol., 1: 679, 1969.
  • 6 - Cao, A.: Juvenile chronic myeloid leukemia. Lancet, 1: 1002, 1970.
  • 6a - Cao, A., Leone, N., Trabalzo, N., and Virgiliis, D. S.: Clinical and hematological findings in juvenile type chronic myeloid leukemia. Minerva Pediatrica, 21: 1649, 1969.
  • 7 - Shapira, Y., Polliack, A., Cividalle, G., and Rachmilewitz, E.: Juvenile myeloid leukemia with fetal erythropoiesis. Cancer, 30: 353, 1972.
  • 8 - Bloom, G. E., Gerald, P. S., and Diamont, L. K.: Chronic myelogenous leukemia in an infant. Serial cytogenetic and fetal hemoglobin studies. Pediatrics, 28: 295, 1966.
  • 9 - Stoppoloni, G., Ditaro, R.: Juvenile chronic myeloid leukemia. Lancet, 1: 1176, 1970.
  • 10 - Horton, B. F., and Chernoff, A. I.: The hemoglobin profile in erythroleukemia. Cancer, 26, 1970.
  • 11 - Weatherall, D. J., Brown, N. J.: Juvenile chronic myeloid leukemia. Lancet, 1: 7645: 526, 1970.
  • 12 - Singer, K., Chernoff, A. I., and Singer, J.: Studies on abnormal hemoglobins—alkali denaturation. Blood, 6: 913, 1951.
  • 13 - Kunkel, H. G., Vallenanus, G.: Hemoglobin in normal adult blood. Science, 122: 288, 1955.
  • 14 - Kahn, A., Bovin, P., Wroklans, M., Hakim, J.: Erythroleukemia with dual erythrocyte population: Weakening of blood group antigens, major deficiency in adenylate kinase, and increase in A hemoglobin fraction. Nouvelle Revue Française d’Hématologie, 12: 609, 1972.
  • 15 - Aksoy, M., and Erdem, S.: Decrease in A hemoglobin concentration during erythroleukemia. Nature, 213: 522, 1967.
  • 16 - Williams, J., et al.: Hematology, McGraw-Hill Book Company, New York, p.699, 1972.
There are 17 citations in total.

Details

Primary Language English
Subjects Infant and Child Health
Journal Section Articles
Authors

Ayten Arcasoy This is me

Publication Date December 31, 1973
Published in Issue Year 1973 Volume: 26 Issue: 5-6

Cite

APA Arcasoy, A. (1974). Fötal Eritropoezle Seyreden Eritrolösemi: Fötal Hemoglobinde Artış ve A. Hemoglobinde Azalma ile Karakterize Bir Vaka. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 26(5-6), 1267-1276.
AMA Arcasoy A. Fötal Eritropoezle Seyreden Eritrolösemi: Fötal Hemoglobinde Artış ve A. Hemoglobinde Azalma ile Karakterize Bir Vaka. Ankara Üniversitesi Tıp Fakültesi Mecmuası. January 1974;26(5-6):1267-1276.
Chicago Arcasoy, Ayten. “Fötal Eritropoezle Seyreden Eritrolösemi: Fötal Hemoglobinde Artış Ve A. Hemoglobinde Azalma Ile Karakterize Bir Vaka”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 26, no. 5-6 (January 1974): 1267-76.
EndNote Arcasoy A (January 1, 1974) Fötal Eritropoezle Seyreden Eritrolösemi: Fötal Hemoglobinde Artış ve A. Hemoglobinde Azalma ile Karakterize Bir Vaka. Ankara Üniversitesi Tıp Fakültesi Mecmuası 26 5-6 1267–1276.
IEEE A. Arcasoy, “Fötal Eritropoezle Seyreden Eritrolösemi: Fötal Hemoglobinde Artış ve A. Hemoglobinde Azalma ile Karakterize Bir Vaka”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 26, no. 5-6, pp. 1267–1276, 1974.
ISNAD Arcasoy, Ayten. “Fötal Eritropoezle Seyreden Eritrolösemi: Fötal Hemoglobinde Artış Ve A. Hemoglobinde Azalma Ile Karakterize Bir Vaka”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 26/5-6 (January1974), 1267-1276.
JAMA Arcasoy A. Fötal Eritropoezle Seyreden Eritrolösemi: Fötal Hemoglobinde Artış ve A. Hemoglobinde Azalma ile Karakterize Bir Vaka. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1974;26:1267–1276.
MLA Arcasoy, Ayten. “Fötal Eritropoezle Seyreden Eritrolösemi: Fötal Hemoglobinde Artış Ve A. Hemoglobinde Azalma Ile Karakterize Bir Vaka”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 26, no. 5-6, 1974, pp. 1267-76.
Vancouver Arcasoy A. Fötal Eritropoezle Seyreden Eritrolösemi: Fötal Hemoglobinde Artış ve A. Hemoglobinde Azalma ile Karakterize Bir Vaka. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1974;26(5-6):1267-76.